Standardisation of thrombin generation test - which reference plasma for TGT?: An international multicentre study

Thrombosis Research

Volumn 125, Issue 4, 2010, Pages 353-356

  Dargaud, Y ^a   Luddington, R ^b   Gray, E ^c   Lecompte, T ^d   Siegemund, T ^e   Baglin, T ^b   Hogwood, J ^c   Regnault, V ^d   Siegemund, A ^e   Negrier, C ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^d INSERM   (France)

^e UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Calibrated automated thrombin generation assay; Corn trypsin inhibitor; Endogenous thrombin potential; Reference plasma; Standardisation

Indexed keywords

ADULT; ARTICLE; CASE REPORT; HUMAN; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; STANDARDIZATION; THROMBIN TIME;

CALIBRATION; EUROPE; HEMATOLOGIC TESTS; HEMOSTASIS; HUMANS; INDICATORS AND REAGENTS; LABORATORIES; LABORATORY TECHNIQUES AND PROCEDURES; PLASMA; REFERENCE STANDARDS; THROMBIN;

EID: 77949567116     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.11.012     Document Type: Article

References (14)

1. Macfarlane R.G., and Biggs R. A thrombin generation test. The application in haemophilia and thrombocytopenia. J Clin Pathol 6 (1953) 3-8
2. Pitney W.R., and Dacie J.V. A simple method of studying the generation of thrombin in recalcified plasma. Application in the investigation of haemophilia. J Clin Pathol 6 (1953) 9-14
3. Hemker H.C., Willems G.M., and Beguin S. A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. Thromb Haemost 56 (1986) 9-17
4. Hemker H.C., Giesen P.L.A., Ramjee M., Wagenvoord R., and Beguin S. Thr thrombogram: monitoring thrombin generation in platelet rich plasma. Thromb Haemost 83 (2000) 589-591
5. Hemker H.C., and Giesen P. Al Dieri R, Regnault V, de Smed E, Wagenvoord R, Lecompte T, Beguin S. Calibarated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 33 (2003) 4-15
6. Dargaud Y., Beguin S., Lienhart A., Al Dieri R., Trzeciak C., Bordet J.C., Hemker H.C., and Negrier C. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Thromb Haemost 93 (2005) 475-480
7. Trossaërt M., Regnault V., Sigaud M., Boisseau P., Fressinaud E., and Lecompte T. Mild hemophilia A with factor VIII assay discrepancy: using thrombin generation assay to assess the bleeding phenotype. J Thromb Haemost 6 (2008) 486-493
8. Besser M., Baglin C., Luddington R., van Hylckama Vlieg A., and Baglin T. High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study. J Thromb Haemost 6 (2008) 1720-1725
9. Lecompte T., Wahl D., Perret-Guillaume C., Hemker H.C., Lacolley P., and Regnault V. Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk. Haematologica 92 (2007) 714-715
10. Dargaud Y., Lambert T., and Trossaert M. New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors. Haemophilia 14 Suppl 4 (2008) 20-27
11. Lewis S.J., Stefens E., Florou G., Macartney N.J., Hathaway L.S., Knipping J., and Collins P.W. Measurement of global haemostasis in severe haemophilia A following FVIII infusion. Br J Haematol 138 (2007) 775-782
12. Gerotziafas G.T., Depasse F., Busson J., Leflem L., Elalamy I., and Samama M.M. Towards a standardisation of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay. Thromb J 3 (2005) 16-27
13. Dargaud Y., Luddington R., Gray E., Negrier C., Lecompte T., Petros S., Hogwood J., Bordet J.C., Regnault V., Siegemund A., and Baglin T. Effect of standardisation and normalisation on imprecision of Calibrated automated thrombography (CAT): an international multicentre study. Br J Haematol 139 (2007) 303-309
14. Hemker H.C., De Smedt E., and Hemker P.W. During coagulation, thrombin generation shifts from chemical to diffusional control. J Thromb Haemost 3 (2005) 2399-2400