Placebo group improvement in trials of pharmacotherapies for alcohol use disorders: A multivariate meta-analysis examining change over time

Journal of Clinical Psychopharmacology

Volumn 33, Issue 5, 2013, Pages 649-657

  Del Re, A C ^a,b   Maisel, Natalya ^a,b   Blodgett, Janet C ^a,b   Wilbourne, Paula ^a,b   Finney, John W ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; NALTREXONE; PLACEBO; SERTRALINE; TOPIRAMATE;

ALCOHOL USE DISORDER; ALCOHOLISM; ARTICLE; DISEASE SEVERITY; DRUG MARKETING; GENERAL CONDITION IMPROVEMENT; HEALTH CARE POLICY; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PHARMACEUTICAL CARE; PLACEBO EFFECT; PRACTICE GUIDELINE; PREDICTIVE VALUE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; PSYCHOSOCIAL CARE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ALCOHOL-RELATED DISORDERS; CONTROLLED CLINICAL TRIALS AS TOPIC; HUMANS; MULTIVARIATE ANALYSIS; PLACEBO EFFECT; RESEARCH DESIGN; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84883754301     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3182983e73     Document Type: Article

References (47)

1. Moerman DE, Jonas WB. Deconstructing the placebo effect and finding the meaning response. Ann Intern Med. 2002;136(6):471-476
2. Tracey I. Getting the pain you expect: Mechanisms of placebo, nocebo and reappraisal effects in humans. Nat Med. 2010;16(11):1277-1283
3. Wampold BE, Minami T, Tierney SC, et al. The placebo is powerful: Estimating placebo effects in medicine and psychotherapy from randomized clinical trials. J Clin Psychol. 2005;61(7):835-854
4. Carmen B, Angeles M, Ana M, et al. Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: A systematic review. Addiction. 2004;99(7):811-828
5. Garbutt JC, West SL, Carey TS, et al. Pharmacological treatment of alcohol dependence. JAMA. 1999;281(14):1318-1325
6. Kranzler HR. Evidence-based treatments for alcohol dependence. JAMA. 2006;295(17):2075-2076
7. Kranzler HR, Kirk J. Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-Analysis. Alcohol Clin Exp Res. 2001;25(9):1335-1341
8. Feinn R, Kranzler HR. Does effect size in naltrexone trials for alcohol dependence differ for single-site vs. multi-center studies? Alcohol Clin Exp Res. 2005;29(6):983-988
9. Hróbjartsson A, Gotzsche PC. Is the placebo powerless? N Engl J Med. 2001;344(21):1594-1602
10. Hróbjartsson A, Gotzsche PC. Placebo interventions for all clinical conditions. Cochrane Database Syst Rev. 2010;1:CD003974
11. Kienle GS, Kiene H. The powerful placebo effect: Fact or fiction? J Clin Epidemiol. 1997;50(12):1311-1318
12. Wampold BE, Imel ZE, Minami T. The placebo effect: relatively large and robust enough to survive another assault. J Clin Psychol. 2007;63(4):401-403
13. Wampold BE, Imel ZE, Minami T. The story of placebo effects in medicine: Evidence in context. J Clin Psychol. 2007;63(4):379-390
14. Silberman S. Placebos Are Getting More Effective: Drugmakers Are Desperate to Know Why. Wired Magazine. 2009;17:1-8
15. Vance E. Seeking to Illuminate the Mysterious Placebo Effect. The New York Times. 2010. Available at: Http://www.nytimes.com/2010/06/22/ health/22prof.html. Accessed November 29, 2011
16. Kemp AS, Schooler NR, Kalali AH, et al. What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it? Schizophr Bull. 2010;36(3):504-509
17. Rief W, Nestoriuc Y, Weiss S, et al. Meta-Analysis of the placebo response in antidepressant trials. J Affect Disord. 2009;118(1-3):1-8
18. Blackwell B, Bloomfield SS, Buncher CR. Demonstration to medical students of placebo responses and non-drug factors. Lancet. 1972;299(7763):1279-1282
19. Lasagna L, Mosteller F, von Felsinger JM, et al. A study of the placebo response. Am J Med. 1954;16(6):770-779
20. Finney JW. Regression to the mean in substance use disorder treatment research. Addiction. 2008;103(1):42-52
21. Miller WR, Wilbourne PL. Mesa Grande: A methodological analysis of clinical trials of treatments for alcohol use disorders. Addiction. 2002;97(3):265-277
22. Donovan D, Ernst D, Miller W, et al. In: Pettinati HM, Weiss RD, Miller WR, et al, eds. COMBINE Monograph Series, Volume 2. Medical Management Treatment Manual: A Clinical Research Guide for Medically Trained Clinicians Providing Pharmacotherapy as Part of the Treatment for Alcohol Dependence. Bethesda, MD: DHHS Publication No. (NIH) 04-5289. NIAAA; 2004
23. Cooper HM, Hedges LV, Valentine JC. New York: The Handbook of Research Synthesis and Meta-Analysis. New York: Russell Sage Foundation Publications; 2009
24. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988
25. Hedges LV, Olkin I, Statistiker M. Statistical Methods for Meta-Analysis. Orlando, FL: Academic Press; 1985
26. compute.es: Compute effect sizes [statistical software program].R package version 0.3. Palo Alto, CA: Del Re, AC; 2012
27. Chick J, Anton R, Checinski K, et al. A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. Alcohol Alcohol. 2000;35(6):587-593
28. Hunter JE, Schmidt FL. Methods of Meta-Analysis: Correcting Error and Bias in Research Findings. Thousand Oaks, CA: Sage Publications, Inc; 2004
29. Gleser LJ, Olkin I. Stochastically dependent effect sizes. In: Cooper HM, Hedges LV, eds. The Handbook of Research Synthesis and Meta-Analysis. 2nd ed. New York, NY: Russell Sage Foundation Publications; 2009;339-355
30. Riley RD. Multivariate meta-Analysis: The effect of ignoring within-study correlation. J R Stat Soc Ser A Stat Soc. 2009;172(4):789-811
31. Farber BA, Doolin EM. Positive regard. Psychotherapy (Chic). 2011;48(1):58-64
32. Flückiger C, Del Re A, Wampold BE, et al. How central is the alliance in psychotherapy? A multilevel longitudinal meta-Analysis. J Couns Psychol. 2012;59(1):10-17
33. Wampold BE, Budge S, Laska KM, et al. Evidence-based treatments for depression and anxiety versus treatment-As-usual: A meta-Analysis of direct comparisons. Clin Psychol Rev. 2011;31(8):1304-1312
34. Horvath AO, Del Re AC, Flückiger C, et al. Alliance in individual psychotherapy. Psychotherapy (Chic). 2011;48(1):9-16
35. Wampold BE, Mondin GW, Moody M, et al. A meta-Analysis of outcome studies comparing bona fide psychotherapies: Empirically, all must have prizes. Psychol Bull. 1997;122(3):203-215
36. MAd: Meta-Analysis with mean differences [statistical software program].R package version 0.3. Palo Alto, CA: Del Re, AC, Hoyt, WT; 2012
37. Guardia J, Caso C, Arias F, et al. A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol-dependence disorder: Results from a multicenter clinical trial. Alcohol Clin Exp Res. 2002;26(9):1381-1387
38. Balldin J, Berglund M, Borg S, et al. A 6-month controlled naltrexone study: Combined effect with cognitive behavioral therapy in outpatient treatment of alcohol dependence. Alcohol Clin Exp Res. 2003;27(7):1142-1149
39. Viechtbauer W. Conducting meta-Analyses in R with the metafor package. J Stat Softw. 2010;36(3):1-48
40. mvmeta: Multivariate meta-Analysis and meta-regression [statistical software program]. R package version 0.2.4. London, UK: Gasparrini A; 2012
41. Raudenbush SW, Bryk AS. Hierarchical Linear Models: Applications and Data Analysis Methods. Thousand Oaks, CA: Sage Publications, Inc; 2002
42. Jackson D, Riley R, White IR. Multivariate meta-Analysis: Potential and promise. Stat Med. 2011;30(20):2481-2498
43. Addolorato G, Leggio L, Ferrulli A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: Randomised, double-blind controlled study. Lancet. 2007;370(9603):1915-1922
44. Mark TL, Kranzler HR, Poole VH, et al. Barriers to the use of medications to treat alcoholism. Am J Addict. 2003;12(4):281-294
45. MacKinnon DP, Krull JL, Lockwood CM. Equivalence of the mediation, confounding and suppression effect. Prev Sci. 2000;1(4):173-181
46. Lumley T. Network meta-Analysis for indirect treatment comparisons. Stat Med. 2002;21:2313-2324
47. Del Re AC, Spielmans GI, Flückiger C, et al. Efficacy of New Generation Antidepressants: Differences Seem Illusory. PLoS ONE. 2013;8(6):e63509