Does medication adherence lead to lower healthcare expenses for patients with diabetes?

American Journal of Managed Care

Volumn 19, Issue 8, 2013, Pages 662-670

  Cheng, Shou Hsia ^a   Chen, Chi Chen ^a   Tseng, Chin Hsiao ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; BIGUANIDE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ORAL ANTIDIABETIC AGENT; SULFONAMIDE; SULFONYLUREA DERIVATIVE;

ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; DISEASE DURATION; DRUG COST; EMERGENCY WARD; HEALTH CARE COST; HOSPITALIZATION COST; HUMAN; MEDICATION COMPLIANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; TAIWAN;

DIABETES MELLITUS, TYPE 2; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEALTH CARE COSTS; HOSPITALIZATION; HUMANS; HYPOGLYCEMIC AGENTS; LONGITUDINAL STUDIES; MALE; MEDICATION ADHERENCE; MIDDLE AGED; TAIWAN; UNIVERSAL COVERAGE;

EID: 84883751327     PISSN: 10880224     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bethel MA, Sloan FA, Belsky D, Feinglos MN. Longitudinal incidence and prevalence of adverse outconmes of diabetes mellitus in elderly patients. Arch Intern Med. 2007;167(9):921-927. (Pubitemid 46762754)
2. Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D'Agostino RB Sr. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006;113(25): 2914-2918. (Pubitemid 44297232)
3. Tseng CH, Tseng CP, Chong CK, et al. Increasing incidence of diagnosed type 2 diabetes in Taiwan: analysis of data from a national cohort. Diabetologia. 2006;49(8):1755-1760. (Pubitemid 44025029)
4. Chang HY, Hsu CC, Pan WH, et al. Gender differences in trends in diabetes prevalence from 1993 to 2008 in Taiwan. Diabetes Res Clin Pract. 2010;90(3):358-364.
5. American Diabetes Association. Economic costs of diabetes in the U.S. in 2007. Diabetes Care. 2008;31(3):596-615.
6. Bureau of National Health Insurance. The 2009 report of National Health Insurance Annual Statistical report, 2010 [in Chinese].
7. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405-412. (Pubitemid 30609442)
8. Hearnshaw H, Lindenmeyer A. What do we mean by adherence to treatment and advice for living with diabetes? a review of the literature on definitions and measurements. Diabet Med. 2006;23(7):720-728. (Pubitemid 44366069)
9. Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004;27(5):1218-1224. (Pubitemid 38579798)
10. Asche C, LaFleur J, Conner C. A review of diabetes treatment adherence and the association with clinical and economic outcomes. Clin Ther. 2011;33(1):74-109.
11. Hepke KL, Martus MT, Share DA. Costs and utilization associated with pharmaceutical adherence in a diabetic population. Am J Manag Care. 2004;10(2, pt 2):144-151.
12. Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43(6):521-530. (Pubitemid 40847288)
13. Roebuck MC, Liberman JN, Gemmill-Toyama M, Brennan TA. Medication adherence leads to lower health care use and costs despite increased drug spending. Health Aff. 2011;30(1):91-99.
14. Salas M, Hughes D, Zuluaga A, Vardeva K, Lebmeier M. Costs of medication nonadherence in patients with diabetes mellitus: a systematic review and critical analysis of the literature. Value Health. 2009; 12(6):915-922.
15. Stuart B, Davidoff A, Lopert R, Shaffer T, Samantha Shoemaker J, Lloyd J. Does medication adherence lower Medicare spending among beneficiaries with diabetes? Health Serv Res. 2011;46(4):1180-1199.
16. Stock JH, Watson MW. Introduction to Econometrics. Boston: Addison Wesley; 2003.
17. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika. 1983;70(1): 41-55.
18. Lau DT, Nau DP. Oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabetes Care. 2004;27(9):2149-2153. (Pubitemid 39167177)
19. Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836-1841. (Pubitemid 44455165)
20. Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC. An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patients. Med Care.2008;46(11):1125-1133.
21. Hansen RA, Farley JF, Droege M, Maciejewski ML. A retrospective cohort study of economic outcomes and adherence to monotherapy with metformin, pioglitazone, or a sulfonylurea among patients with type 2 diabetes mellitus in the united states from 2003 to 2005. Clin Ther. 2010;32(7):1308-1319.
22. Balkrishnan R, Rajagopalan R, Camacho FT, Huston SA, Murray FT, Anderson RT. Predictors of medication adherence and associated health care costs in an older population with type 2 diabetes mellitus: a longitudinal cohort study. Clin Ther. 2003;25(11):2958-2971. (Pubitemid 37510603)
23. Hong JS, Kang HC. Relationship between oral antihyperglycemic medication adherence and hospitalization, mortality, and healthcare costs in adult ambulatory care patients with type 2 diabetes in South Korea. Med Care. 2011;49(4):378-384.
24. Gibson TB, Song X, Alemayehu B, et al. Cost sharing, adherence, and health outcomes in patients with diabetes. Am J Manag Care. 2010;16(8):589-600.
25. Gu Q, Zeng F, Patel BV, Tripoli LC. Part D coverage gap and adherence to diabetes medications. Am J Manag Care. 2010;16(12):911-918.
26. Chernew ME, Rosen AB, Fendrick AM. Value-based insurance design. Health Aff. 2007;26(2):w195-w203.
27. Cheng TM. Taiwan's new national health insurance program: genesis and experience so far. Health Aff (Millwood). 2003;22(3):61-76.
28. Lin CC, Lai MS, Syu CY, Chang SC, Tseng FY. Accuracy of diabetes diagnosis in health insurance claims data in Taiwan. J Formos Med Assoc. 2005;104(3):157-163. (Pubitemid 44524953)
29. Young BA, Lin E, Von Korff M, et al. Diabetes complications severity index and risk of mortality, hospitalization, and healthcare utilization. Am J Manag Care. 2008;14(1):15-23.
30. Meduru P, Helmer D, Rajan M, Tripoli LC. Chronic illness with complexity: implications for performance measurement of optimal glycemic control. J Gen Intern Med. 2007;22(suppl 3):408-418. (Pubitemid 350172455)
31. Lee TT, Cheng SH, Chen CC, Lai MS. A pay-for-performance program for diabetes care in Taiwan: a preliminary assessment. Am J Manag Care. 2010;16(1):65-69.
32. Cheng SH, Lee TT, Chen CC. A longitudinal examination of a payfor- performance program for diabetes care: evidence from a natural experiment. Med Care. 2012;50(2):109-116.
33. Huang P, Hsu YH, Kai-Yuan T, Hsueh YS. Can European external peer review techniques be introduced and adopted into Taiwan's hospital accreditation system? Int J Qual Health Care. 2000;12(3):251-254. (Pubitemid 30429708)
34. Diggle P, Heagerty P, Liang KY. Analysis of Longitudinal. New York, NY: Oxford; 2002.
35. Austin PC, Ghali WA, Tu JV. A comparison of several regression models for analysing cost of CABG surgery. Stat Med. 2003;22(17):2799-2815. (Pubitemid 37045310)
36. Adler AI, Stevens RJ, Manley SE, et al. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 2003;63(1):225-232. (Pubitemid 35463925)
37. Fox CS, Sullivan L, D'Agostino RB Sr, Wilson PW; FraminghamHeart Study. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care. 2004;27(3):704-708. (Pubitemid 38280537)
38. Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Pharmacoepidemiol Drug Saf. 2009;18(2):159-165.