Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia

Pediatric Research

Volumn 74, Issue 3, 2013, Pages 290-298

  Fleck, Shannon ^a   Bautista, Geoanna ^b   Keating, Sheila M ^c   Lee, Tzong Hae ^c   Keller, Roberta L ^a,b   Moon Grady, Anita J ^a,b   Gonzales, Kelly ^b   Norris, Philip J ^b,c   Busch, Michael P ^b,c   Kim, C J ^d   Romero, Roberto ^d   Lee, Hanmin ^a,b   Miniati, Doug ^a,b   Mackenzie, Tippi C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^d HUTZEL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR;

ADULT; ARTICLE; CELL MIGRATION; CLINICAL ARTICLE; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FETUS; HUMAN; IMMUNOASSAY; MATERNAL BLOOD; MOTHER FETUS RELATIONSHIP; PREDICTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD;

BIOLOGICAL MARKERS; CHEMOKINES; EPIDERMAL GROWTH FACTOR; FETAL BLOOD; FETUS; HERNIA, DIAPHRAGMATIC; HUMANS; HYPERTENSION, PULMONARY; IMMUNOASSAY; INFLAMMATION MEDIATORS; LOGISTIC MODELS; PLATELET-DERIVED GROWTH FACTOR; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84883720629     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.98     Document Type: Article

References (37)

1. Deprest JA, Gratacos E, Nicolaides K, et al. Changing perspectives on The perinatal management of isolated congenital diaphragmatic hernia in Europe. Clin Perinatol 2009;36:329-47, ix.
2. Jelin E, Lee H. Tracheal occlusion for fetal congenital diaphragmatic hernia: The US experience. Clin Perinatol 2009;36:349-61, ix.
3. Ruano R, Duarte SA, Pimenta EJ, et al. Comparison between fetal endoscopic tracheal occlusion using a 1.0-mm fetoscope and prenatal expectant management in severe congenital diaphragmatic hernia. Fetal Diagn Ther 2011;29:64-70.
4. Jancelewicz T, Vu LT, Keller RL, et al. Outcomes of multigestational pregnancies affected by congenital diaphragmatic hernia. J Pediatr Surg 2010;45:1753-8.
5. Hedrick HL, Danzer E, Merchant A, et al. Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia. Am J Obstet Gynecol 2007;197:422.e1-4.
6. Dillon PW, Cilley RE, Mauger D, Zachary C, Meier A. The relationship of pulmonary artery pressure and survival in congenital diaphragmatic hernia. J Pediatr Surg 2004;39:307-12; discussion 307-12.
7. Keller RL, Tacy TA, Hendricks-Munoz K, et al. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med 2010;182:555-61.
8. Fuke S, Kanzaki T, Mu J, et al. Antenatal prediction of pulmonary hypoplasia by acceleration time/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry. Am J Obstet Gynecol 2003;188:228-33.
9. Broth RE, Wood DC, Rasanen J, et al. Prenatal prediction of lethal pulmonary hypoplasia: The hyperoxygenation test for pulmonary artery reactivity. Am J Obstet Gynecol 2002;187:940-5.
10. Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F. Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol 2011;8:443-55.
11. Hassoun PM, Mouthon L, Barber?JA, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 2009;54:Suppl 1:S10-9.
12. Mychaliska GB, Rice HE, Tarantal AF, et al. In utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys. J Pediatr Surg 1997;32:976-81.
13. Hall JM, Lingenfelter P, Adams SL, Lasser D, Hansen JA, Bean MA. Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 1995;86:2829-32.
14. Merklinger SL, Jones PL, Martinez EC, Rabinovitch M. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 2005;112:423-31.
15. Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005;115:2811-21.
16. Grimminger F, Schermuly RT. PDGF receptor and its antagonists: role in treatment of PAH. Adv Exp Med Biol 2010;661:435-46.
17. Dhillon S, Kaker A, Dosanjh A, Japra D, Vanthiel DH. Irreversible pulmonary hypertension associated with The use of interferon alpha for chronic hepatitis C. Dig Dis Sci 2010;55:1785-90.
18. Humbert M, Monti G, Brenot F, et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 1995;151:1628-31.
19. Soon E, Holmes AM, Treacy CM, et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation 2010;122:920-7.
20. Balabanian K, Foussat A, Dorfm?ler P, et al. CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am J Respir Crit Care Med 2002;165:1419-25.
21. Izikki M, Guignabert C, Fadel E, et al. Endothelial-derived FGF2 contributes to The progression of pulmonary hypertension in humans and rodents. J Clin Invest 2009;119:512-23.
22. Schaible T, Veit M, Tautz J, et al. Serum cytokine levels in neonates with congenital diaphragmatic hernia. Klin Padiatr 2011;223:414-8.
23. Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA 1996;93:705-8.
24. Maloney S, Smith A, Furst DE, et al. Microchimerism of maternal origin persists into adult life. J Clin Invest 1999;104:41-7.
25. Mold JE, Micha?sson J, Burt TD, et al. Maternal alloantigens promote The development of tolerogenic fetal regulatory T cells in utero. Science 2008;322:1562-5.
26. Hayashida K, Fujita J, Miyake Y, et al. Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension. Chest 2005;127:1793-8.
27. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest 2011;121:582-92.
28. Saadai P, Lee TH, Bautista G, et al. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg 2012;47:1089-94.
29. Danzer E, Davey MG, Kreiger PA, et al. Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles. J Pediatr Surg 2008;43:1767-75.
30. O'Callaghan DS, Savale L, Montani D, et al. Treatment of pulmonary arterial hypertension with targeted therapies. Nat Rev Cardiol 2011;8:526-38.
31. Davey M, Shegu S, Danzer E, et al. Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/ glucocorticoid therapy. Am J Obstet Gynecol 2007;197:381.e1-7.
32. Luong C, Rey-Perra J, Vadivel A, et al. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 2011;123:2120-31.
33. Guarino N, Solari V, Shima H, Puri P. Upregulated expression of EGF and TGF-alpha in The proximal respiratory epithelium in The human hypoplastic lung in congenital diaphragmatic hernia. Pediatr Surg Int 2004;19: 755-9.
34. Chang YT, Ringman Uggla A, Osterholm C, et al. Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 2012;302:L1159-66.
35. Frenckner B, Broom?M, Lindstr? M, Radell P. Platelet-derived growth factor inhibition-A new treatment of pulmonary hypertension in congenital diaphragmatic hernia? J Pediatr Surg 2008;43:1928-31.
36. Keating SM, Golub ET, Nowicki M, et al.; Women's Interagency HIV Study. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women. AIDS 2011;25:1823-32.
37. Lee TH, Chafets DM, Reed W, et al. Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms. Transfusion 2006;46: 1870-8.