Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 11, 2012, Pages

  Chang, Ya Ting ^a   Uggla, Andreas Ringman ^a   Österholm, Cecilia ^a   Tran, Phan Kiet ^b   Eklöf, Ann Christine ^a   Lengquist, Mariette ^a   Hedin, Ulf ^a   Tran Lundmark, Karin ^a   Frenckner, Björn ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

PDGF; Pulmonary hypertension

Indexed keywords

CASPASE 3; IMATINIB; KI 67 ANTIGEN; NITROFEN; OLIVE OIL; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTERIAL WALL THICKNESS; ARTICLE; CELL PROLIFERATION; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DRUG EFFECT; FETUS; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; MORPHOMETRICS; NONHUMAN; PRENATAL CARE; PRIORITY JOURNAL; PROTEIN PURIFICATION; PULMONARY ARTERY; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; WESTERN BLOTTING;

AIRWAY REMODELING; ANIMALS; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HERNIA, DIAPHRAGMATIC; KI-67 ANTIGEN; LUNG; PHENYL ETHERS; PIPERAZINES; PLATELET-DERIVED GROWTH FACTOR; PREGNANCY; PULMONARY ARTERY; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RNA, MESSENGER;

EID: 84861846385     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00325.2010     Document Type: Article

References (42)

1. Investigators Brochure, 571 (formerly CGP 57148B) STI, and data on file. Basel, Switzerland: Novartis Pharma AG, 2004.
2. Abellar RG, Pepperell JR, Greco D, Gundogan F, Kostadinov S, Schwartz J, Tantravahi U, De Paepe ME. Effects of chemotherapy during pregnancy on the placenta. Pediatr Dev Pathol 12: 35-41, 2009.
3. Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312, 2008.
4. Balasubramaniam V, Le Cras TD, Ivy DD, Grover TR, Kinsella JP, Abman SH. Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 284: L826-L833, 2003.
5. Bostrom H, Gritli-Linde A, Betsholtz C. PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn 223: 155-162, 2002.
6. Capdeville R, Buchdunger E, Zimmermann J, Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 1: 493-502, 2002.
7. Chazova I, Loyd JE, Zhdanov VS, Newman JH, Belenkov Y, Meyrick B. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. Am J Pathol 146: 389-397, 1995.
8. Chinoy MR. Pulmonary hypoplasia and congenital diaphragmatic hernia: advances in the pathogenetics and regulation of lung development. J Surg Res 106: 209-223, 2002.
9. Dingemann J, Doi T, Ruttenstock E, Puri P. Abnormal platelet-derived growth factor signaling accounting for lung hypoplasia in experimental congenital diaphragmatic hernia. J Pediatr Surg 45: 1989-1994, 2010.
10. Distler JH, Jungel A, Huber LC, Schulze-Horsel U, Zwerina J, Gay RE, Michel BA, Hauser T, Schett G, Gay S, Distler O. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 56: 311-322, 2007.
11. Frenckner B, Broome M, Lindstrom M, Radell P. Platelet-derived growth factor inhibition-a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? J Pediatr Surg 43: 1928-1931, 2008.
12. Garcia-Olivas R, Vilaro S, Reina M, Castel S. PDGF-stimulated cell proliferation and migration of human arterial smooth muscle cells. Colocalization of PDGF isoforms with glycosaminoglycans. Int J Biochem Cell Biol 39: 1915-1929, 2007.
13. Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock AJ, Barst RJ, Shapiro S, Golpon H, Toshner M, Grimminger F, Pascoe S. Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. Am J Respir Crit Care Med 182: 1171-1177, 2010.
14. Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 353: 1412-1413, 2005.
15. Hatano M, Yao A, Shiga T, Kinugawa K, Hirata Y, Nagai R. Imatinib mesylate has the potential to exert its efficacy by down-regulating the plasma concentration of platelet-derived growth factor in patients with pulmonary arterial hypertension. Int Heart J 51: 272-276, 2010.
16. Hoeper MM, Bourge R, Feldman JA, Frost AE, Galie N, Angel M, Sanchez G, Gruenig E, Hassoun P, Morrell N, Peacock A, Satoh T, Simonneau G, Tapson V, Torres F, Liu K, Quinn D, Ghofrani H. Imatinib in pulmonary arterial hypertension, a randomized efficacy study (IMPRES) (Abstract). Eur Respir J 38: 413, 2011.
17. Hughes AD, Patel M, Wijetunge S, Clunn G, Schachter M. Comparison of effects of platelet-derived growth factor isoforms on signaling and DNA synthesis of human cultured saphenous vein cells. J Cardiovasc Pharmacol 25: 481-485, 1995.
18. Humbert M, Monti G, Fartoukh M, Magnan A, Brenot F, Rain B, Capron F, Galanaud P, Duroux P, Simonneau G, Emilie D. Plateletderived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients. Eur Respir J 11: 554-559, 1998.
19. Jones R, Capen D, Jacobson M. PDGF and microvessel wall remodeling in adult lung: imaging PDGF-Rbeta and PDGF-BB molecules in progenitor smooth muscle cells developing in pulmonary hypertension. Ultrastruct Pathol 30: 267-281, 2006.
20. Jones R, Capen D, Jacobson M, Munn L. PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension. Cell Tissue Res 326: 759-769, 2006.
21. Kitagawa M, Hislop A, Boyden EA, Reid L. Lung hypoplasia in congenital diaphragmatic hernia. A quantitative study of airway, artery, and alveolar development. Br J Surg 58: 342-346, 1971.
22. Kluth D, Kangah R, Reich P, Tenbrinck R, Tibboel D, Lambrecht W. Nitrofen-induced diaphragmatic hernias in rats: an animal model. J Pediatr Surg 25: 850-854, 1990.
23. Kresch MJ, Christian C, Wu F, Hussain N. Ontogeny of apoptosis during lung development. Pediatr Res 43: 426-431, 1998.
24. Langham MR Jr, Kays DW, Ledbetter DJ, Frentzen B, Sanford LL, Richards DS. Congenital diaphragmatic hernia, epidemiology, and outcome. Clin Perinatol 23: 671-688, 1996.
25. Lau M, Masood A, Yi M, Belcastro R, Li J, Tanswell AK. Long-term failure of alveologenesis after an early short-term exposure to a PDGFreceptor antagonist. Am J Physiol Lung Cell Mol Physiol 300: L534-L547, 2011.
26. Levin DL, Fixler DE, Morriss FC, Tyson J. Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors. J Pediatr 92: 478-483, 1978.
27. Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277: 242-245, 1997.
28. Lindahl P, Karlsson L, Hellstrom M, Gebre-Medhin S, Willetts K, Heath JK, Betsholtz C. Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124: 3943-3953, 1997.
29. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103: 1393-1401, 2008.
30. Mohseni-Bod H, Bohn D. Pulmonary hypertension in congenital diaphragmatic hernia. Semin Pediatr Surg 16: 126-133, 2007.
31. Nakamura Y, Harada K, Yamamoto I, Uemura Y, Okamoto K, Fukuda S, Hashimoto T. Human pulmonary hypoplasia. Statistical, morphological, morphometric, and biochemical study. Arch Pathol Lab Med 116: 635-642, 1992.
32. Perros F, Montani D, Dorfmuller P, Durand-Gasselin I, Tcherakian C, Le Pavec J, Mazmanian M, Fadel E, Mussot S, Mercier O, Herve P, Emilie D, Eddahibi S, Simonneau G, Souza R, Humbert M. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 178: 81-88, 2008.
33. Raines EW. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 15: 237-254, 2004.
34. Reid LR. Diaphragmatic hernia of the liver with review of the literature. Miss Doct 28: 351-357, 1951.
35. Russell MA, Carpenter MW, Akhtar MS, Lagattuta TF, Egorin MJ. Imatinib mesylate and metabolite concentrations in maternal blood, umbilical cord blood, placenta and breast milk. J Perinatol 27: 241-243, 2007.
36. Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimminger F. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115: 2811-2821, 2005.
37. Selimovic N, Bergh CH, Andersson B, Sakiniene E, Carlsten H, Rundqvist B. Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension. Eur Respir J 34: 662-668, 2009.
38. Skoumalova I, Vondrakova J, Rohon P, Rozmanova S, Jarosova M, Indrak K, Prochazka M, Santava A, Faber E. Successful childbirth in a patient with chronic myelogenous leukemia treated with imatinib mesylate during early pregnancy. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 152: 121-123, 2008.
39. ten Freyhaus H, Dumitrescu D, Berghausen E, Vantler M, Caglayan E, Rosenkranz S. Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs 21: 119-134, 2012.
40. Tenbrinck R, Gaillard JL, Tibboel D, Kluth D, Lachmann B, Molenaar JC. Pulmonary vascular abnormalities in experimentally induced congenital diaphragmatic hernia in rats. J Pediatr Surg 27: 862-865, 1992.
41. van Dooren MF, Goemaere NN, de Klein A, Tibboel D, de Krijger RR. Postmortem findings and clinicopathological correlation in congenital diaphragmatic hernia. Pediatr Dev Pathol 7: 459-467, 2004.
42. Wilkinson-Berka JL, Babic S, De Gooyer T, Stitt AW, Jaworski K, Ong LG, Kelly DJ, Gilbert RE. Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. Am J Pathol 164: 1263-1273, 2004.