Extracellular neutrophil traps: A novel therapeutic target in ANCA-associated vasculitis?

Frontiers in Immunology

Volumn 4, Issue FRB, 2013, Pages

  Diamantopoulos, Andreas P ^a,b  

^a Southern Norway Hospital Trust   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DNA; HISTONE; MYELOBLASTIN; MYELOPEROXIDASE;

ANCA ASSOCIATED VASCULITIS; CELL ACTIVATION; CELL DEATH; HUMAN; INFECTION; INNATE IMMUNITY; MICROSCOPIC POLYANGIITIS; MYELOID DENDRITIC CELL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NOTE; PLASMACYTOID DENDRITIC CELL; THROMBOCYTE; THROMBUS;

EID: 84883710697     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00024     Document Type: Note

References (16)

1. Bennouna, S., Bliss, S. K., Curiel, T. J., and Denkers, E. Y. (2003). Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J. Immunol. 171, 6052-6058.
2. Bosch, X. (2011). Systemic lupus erythematosus and the neutrophil. N. Engl. J. Med. 365, 758-760.
3. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., et al. (2004). Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535.
4. Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., et al. (2007). Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 13, 463-469.
5. Fuchs, T. A., Brill, A., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D. Jr., et al. (2010). Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. U.S.A. 107, 15880-15885.
6. Kessenbrock, K., Krumbholz, M., Schonermarck, U., Back, W., Gross, W. L., Werb, Z., et al. (2009). Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 15, 623-625.
7. Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J., et al. (2011). Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci. Transl. Med. 3:73ra19. doi: 10.1126/scitranslmed.3001180
8. Mantovani, A., Cassatella, M. A., Costantini, C., and Jaillon, S. (2011). Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11, 519-531.
9. Mitroulis, I., Kambas, K., Chrysanthopoulou, A., Skendros, P., Apostolidou, E., Kourtzelis, I., et al. (2011). Neutrophil extracellular trap formation is associated with IL-1beta and autophagy-related signaling in gout. PLoS ONE 6:e29318. doi: 10.1371/journal.pone.0029318
10. Nakazawa, D., Tomaru, U., Suzuki, A., Masuda, S., Hasegawa, R., Kobayashi, T., et al. (2012a). Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 64, 3779-3787.
11. Nakazawa, D., Tomaru, U., Yamamoto, C., Jodo, S., and Ishizu, A. (2012b). Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis. Front. Immun. 3:333. doi: 10.3389/fimmu.2012.00333
12. Nathan, C. (2006). Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173-182.
13. Phillipson, M., and Kubes, P. (2011). The neutrophil in vascular inflammation. Nat. Med. 17, 1381-1390.
14. Sangaletti, S., Tripodo, C., Chiodoni, C., Guarnotta, C., Cappetti, B., Casalini, P., et al. (2012). Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120, 3007-3018.
15. Semple, J. W., Italiano, J. E. Jr., and Freedman, J. (2011). Platelets and the immune continuum. Nat. Rev. Immunol. 11, 264-274.
16. Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C. T., Semeraro, F., et al. (2009). Extracellular histones are major mediators of death in sepsis. Nat. Med. 15, 1318-1321.