Mechanisms of action of testosterone - Unraveling a Gordian knot

New England Journal of Medicine

Volumn 369, Issue 11, 2013, Pages 1058-1059

  Handelsman, David J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID RECEPTOR; GONADORELIN DERIVATIVE; MINERALOCORTICOID RECEPTOR; PLACEBO; PROGESTERONE RECEPTOR; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

ANDROGEN DEFICIENCY; ANDROGEN THERAPY; DISEASE SEVERITY; DRUG EFFECT; DRUG INDICATION; DRUG MARKETING; DRUG MECHANISM; EDITORIAL; ESTROGEN DEFICIENCY; HORMONE ACTION; HORMONE RESPONSE; HUMAN; PRESCRIPTION; PRIORITY JOURNAL; TESTIS FUNCTION;

EID: 84883707593     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1305307     Document Type: Editorial

References (10)

1. Heldring N, Pike A, Andersson S, et al. Estrogen receptors: how do they signal and what are their targets. Physiol Rev 2007;87:905-31. (Pubitemid 47084672)
2. Scarpin KM, Graham JD, Mote PA, Clarke CL. Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nucl Recept Signal 2009;7:e009.
3. Funder JW. Minireview: aldosterone and mineralocorticoid receptors: past, present, and future. Endocrinology 2010;151:5098-102.
4. Bruchovsky N, Wilson JD. The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 1968;243:2012-21.
5. Naftolin F. Brain aromatization of androgens. J Reprod Med 1994;39:257-61. (Pubitemid 24125864)
6. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocr Rev 2004;25:389-425. (Pubitemid 38786452)
7. Finkelstein JS, Lee H, Burnett-Bowie S-AM, et al. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med 2013;369:1011-22.
8. Storer TW, Magliano L, Woodhouse L, et al. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab 2003;88:1478-85. (Pubitemid 36636978)
9. Idan A, Griffiths KA, Harwood DT, et al. Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial. Ann Intern Med 2010;153:621-32.
10. Handelsman DJ. Commentary: androgens and "anabolic steroids": the one-headed Janus. Endocrinology 2011;152:1752-4.