A validated assay for the simultaneous quantification of six tyrosine kinase inhibitors and two active metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 937, Issue , 2013, Pages 33-43

  Van Erp, Nielka P ^a,b   de Wit, Djoeke ^a   Guchelaar, Henk Jan ^a   Gelderblom, Hans ^a   Hessing, Trees J ^a   Hartigh, Jan den ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

LC MS MS; Metabolites; Tyrosine kinase inhibitors

Indexed keywords

CHROMATOGRAPHIC SYSTEMS; LC-MS/MS; LIQUID CHROMATOGRAPHY COUPLED WITH TANDEM MASS SPECTROMETRIES; LOWER LIMIT OF QUANTIFICATIONS; MULTIPLE-REACTION MONITORING MODES; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRY; TYROSINE KINASE INHIBITOR;

BIOMOLECULES; BODY FLUIDS; ENZYME INHIBITION; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

AMINO ACIDS;

AMMONIUM ACETATE; DASATINIB; DESMETHYL IMATINIB; DESMETHYL SUMATINIB; DRUG METABOLITE; FORMIC ACID; IMATINIB; METHANOL; NILOTINIB; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; REGORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; GAS FLOW; HUMAN; HUMAN TISSUE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; PRECIPITATION; PRIORITY JOURNAL; SERUM; TANDEM MASS SPECTROMETRY; TEMPERATURE; ULTRA PRESSURE LIQUID CHROMATOGRAPHY;

LC-MS/MS; METABOLITES; TYROSINE KINASE INHIBITORS;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; ISOMERISM; LINEAR MODELS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84883675913     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.08.013     Document Type: Article

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