Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 905, Issue , 2012, Pages 137-140

  Sparidans, Rolf W ^a   Ahmed, Tahani T A ^a   Muilwijk, Eline W ^b   Welzen, Marieke E B ^b   Schellens, Jan H M ^a,c   Beijnen, Jos H ^a,c,d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

Human plasma; LC MS MS; Pazopanib; Therapeutic drug monitoring; VEGFR

Indexed keywords

HUMAN PLASMAS; LC-MS/MS; PAZOPANIB; THERAPEUTIC DRUG MONITORING; VEGFR;

ACETONITRILE; AMINO ACIDS; CALIBRATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); POSITIVE IONS; SILICA;

PATIENT MONITORING;

ACETONITRILE; FORMIC ACID; PAZOPANIB; WATER;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DILUTION; DRUG MONITORING; DRUG STABILITY; ELUTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROTEIN PROCESSING; VALIDATION PROCESS;

AGED; CHROMATOGRAPHY, LIQUID; DRUG MONITORING; DRUG STABILITY; FEMALE; HUMANS; LEAST-SQUARES ANALYSIS; LIMIT OF DETECTION; MALE; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 84865802586     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.08.004     Document Type: Article

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