Effect of N-acetylcysteine on pharmacokinetics of acetaminophen in piglets

Journal of Veterinary Pharmacology and Therapeutics

Volumn 36, Issue 5, 2013, Pages 507-510

  Qiu, Y ^a   Cao, F ^a   Xu, J ^a   Ma, H ^a   Zhang, J ^a   Liu, Y ^a  

^a WUHAN POLYTECHNIC UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALF (BOVINE); CHICKEN; CONTROLLED STUDY; DOG; DRUG EFFECT; EXPERIMENTAL PIG; FEMALE; GOAT; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; INFECTION; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MORBIDITY; NONHUMAN; PIGLET; PLASMA CLEARANCE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SHEEP; TURKEY (BIRD);

ACETAMINOPHEN; ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANALGESICS, NON-NARCOTIC; ANIMALS; FEMALE; MALE; SWINE;

EID: 84883657347     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/jvp.12037     Document Type: Article

References (27)

1. Adzu, B., Garba, M., Haruna, A., Maman, M., Wambebe, C. & Gamaniel, K. (2001) Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats. European Journal of Drug Metabolism and Pharmacokinetics, 26, 201-204.
2. Ali, B.H., Cheng, Z., Elhadrami, G., Bashir, A.K. & McKellar, Q.A. (1996) Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulfate and glucuronide metabolites in desert camels and goats. Journal of Veterinary Pharmacology and Therapeutics, 19, 238-244.
3. Doyon, S. & Klein-Schwartz, W. (2009) Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Academic Emergency Medicine, 16, 34-39.
4. Droździk, M., Kwiatkowski, A., Wójcicki, J. & Gawrońska-Szklarz, B. (1994) Effect of mestranol on pharmacokinetics of paracetamol. Acta Poloniae Pharmaceutica, 51, 175-178.
5. Engelking, L.R., Blyden, G.T., Lofstedt, J. & Greenblatt, D.J. (1987) Pharmacokinetics of antipyrine, acetaminophen and lidocaine in fed and fasted horses. Journal of Veterinary Pharmacology and Therapeutics, 10, 73-82.
6. Gelotte, C.K., Auiler, J.F., Lynch, J.M., Temple, A.R. & Slattery, J.T. (2007) Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clinical Pharmacology and Therapeutics, 81, 840-848.
7. Glattleider, L. & Capdevielle, N. (2005) The use of Pracetam (paracetamol) premix in post-weaning multisystemic wasting syndrome (PMWS) and post-weaning diets. The Pig Journal, 56, 131-144.
8. Grochowina, B. & Janus, K. (2006) Pharmacokinetics of paracetamol in calf plasma and saliva. Medycyna Weterynaryjna, 62, 686-689.
9. Heard, K.J. (2008) Acetylcysteine for acetaminophen poisoning. The New England Journal of Medicine, 359, 285-292.
10. Hou, Y., Wang, L., Zhang, W., Yang, Z., Ding, B., Zhu, H., Liu, Y., Qiu, Y., Yin, Y. & Wu, G.. (2012a) Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide. Amino Acids, 43, 1233-1242.
11. Hou, Y., Wang, L., Yi, D., Ding, B., Yang, Z., Li, J., Chen, X., Qiu, Y. & Wu, G. (2012b) N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids. doi: 10.1007/s00726-012-1295-x.
12. Issa, M.M., Nejem, R.M. & El-Abadla, N.S. (2006) Oral ciprofloxacin affects the pharmacokinetics of paracetamol in saliva. Clinical Drug Investigation, 26, 223-226.
13. James, L.P., McCullough, S.S., Lamps, L.W. & Hinson, J.A. (2003) Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicological Sciences, 75, 458-467.
14. Janus, K., Grochowina, B., Antoszek, J., Suszycki, S. & Muszczynski, Z. (2003) The effect of food or water deprivation on paracetamol pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 26, 291-296.
15. Kamali, F. (1993) The effect of probenecid on paracetamol metabolism and pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics, 45, 551-553.
16. KuKanich, B. (2010) Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites morphine and codeine-6-glucuronide in healthy Greyhound dogs. Journal of Veterinary Pharmacology and Thera-peutics, 33, 15-21.
17. Lee, S.K., Bista, S.R., Jeong, H., Kim, D.H., Kang, M.J., Jahng, Y. & Jeong, T.C. (2007) The effects of rutaecarpine on the pharmacokinetics of acetaminophen in rats. Archives of Pharmacal Research, 30, 1629-1634.
18. Monshouwer, M., Witkamp, R.F., Pijpers, A., Verheijden, J.H. & van Miert, A.S. (1994) Dose-dependent pharmacokinetic interaction between antipyrine and paracetamol in vivo and in vitro when administered as a cocktail in pig. Xenobiotica, 24, 347-355.
19. Neirinckx, E., Vervaet, C., De Boever, S., Remon, J.P., Gommeren, K., Daminet, S., De Backer, P. & Croubels, S. (2010) Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen. Research in Veterinary Science, 89, 113-119.
20. Prescott, L.F., Illingworth, R.N., Critchley, J.A.J.H., Stewart, M. J., Adam, R.D. & Proudfoot, A.T. (1979) Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. British Medical Journal, 2, 1097-1100.
21. Savides, M.C., Oehme, F.W., Nash, S.L. & Leipold, H.W. (1984) The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicology and Applied Pharmacology, 74, 26-34.
22. Smilkstein, M.J., Knapp, G.L., Kulig, K.W. & Rumack, B.H. (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). The New England Journal of Medicine, 319, 1557-1562.
23. St. Omer, V.E.V. & Mohammad, F.K. (1984) Effect of antidotal N-acetylcysteine on the pharmacokinetics of acetaminophen in dogs. Journal of Veterinary Pharmacology and Therapeutics, 7, 277-281.
24. Tanner, T., Aspley, S., Munn, A. & Thomas, T. (2010) The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol. BMC Clinical Pharmacology, 10, 10.
25. Tripathi, Y.B., Tiwari, O.P., Nagwani, S. & Mishra, B. (2009) Pharmacokinetic-interaction of Vitex negundo Linn. & paracetamol. Indian Journal of Medical Research, 130, 479-483.
26. Wang, L.H., Rudolph, A.M. & Benet, L.Z. (1990) Comparative study of acetaminophen disposition in sheep at 3 developmental stages-the fetal, neonatal and adult periods. Developmental Pharmacology and Therapeutics, 14, 161-179.
27. Yamasaki, I., Uotsu, N., Yamaguchi, K., Takayanagi, R. & Yamada, Y. (2011) Effects of kale ingestion on pharmacokinetics of acetaminophen in rats. Biomedical Research, 32, 357-362.