Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites morphine and codeine-6-glucuronide in healthy Greyhound dogs

Journal of Veterinary Pharmacology and Therapeutics

Volumn 33, Issue 1, 2010, Pages 15-21

  Kukanich, B ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCODAMOL; CODEINE; CODEINE 6 GLUCURONIDE; DRUG METABOLITE; MORPHINE; PARACETAMOL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TOLERABILITY; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; SEDATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DOGS; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE;

CANIS FAMILIARIS;

EID: 76749137630     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2009.01098.x     Document Type: Article

References (26)

1. Barnhart, M.D., Hubbell, J.A., Muir, W.W., Sams, R.A. Bednarski, R.M. (2000) Pharmacokinetics, pharmacodynamics, and analgesic effects of morphine after rectal, intramuscular, and intravenous administration in dogs. American Journal of Veterinary Research, 61, 24 28.
2. Findlay, J.W., Jones, E.C. Welch, R.M. (1979) Radioimmunoassay determination of the absolute oral bioavailabilities and O-demethylation of codeine and hydrocodone in the dog. Drug Metabolism and Disposition, 7, 310 314.
3. Garrett, E.R., Derendorf, H. Mattha, A.G. (1985) Pharmacokinetics of morphine and its surrogates. VII: High-performance liquid chromatographic analyses and pharmacokinetics of methadone and its derived metabolites in dogs. Journal of Pharmaceutical Sciences, 74, 1203 1214.
4. Gaynor, J.S. (2008) Control of cancer pain in veterinary patients. Veterinary Clinics of North America Small Animal Practice, 38, 1429 1448.
5. Gelotte, C.K., Auiler, J.F., Lynch, J.M., Temple, A.R. Slattery, J.T. (2007) Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clinical Pharmacology and Therapeutics, 81, 840 848.
6. Guedes, A.G., Papich, M.G., Rude, E.P. Rider, M.A. (2008) Pharmacokinetics and physiological effects of intravenous hydromorphone in conscious dogs. Journal of Veterinary Pharmacology and Therapeutics, 31, 334 343.
7. Henao-Guerrero, P.N., McMurphy, R., Kukanich, B. Hodgson, D.S. (2009) Effect of morphine on the bispectral index during isoflurane anesthesia in dogs. Veterinary Anaesthesia and Analgesia, 36, 133 143.
8. Kirchheiner, J., Schmidt, H., Tzvetkov, M., Keulen, J.T., Lötsch, J., Roots, I. Brockmöller, J. (2006) Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. The Pharmacogenomics Journal, 7, 257 265.
9. KuKanich, B. Borum, S.L. (2008) Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds. American Journal of Veterinary Research, 69, 664 669.
10. KuKanich, B. Papich, M.G. (2004a) Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 27, 337 341.
11. KuKanich, B. Papich, M.G. (2004b) Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. Journal of Veterinary Pharmacology and Therapeutics, 27, 239 246.
12. KuKanich, B., Lascelles, B.D., Aman, A.M., Mealey, K.L. Papich, M.G. (2005a) The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs. Journal of Veterinary Pharmacology and Therapeutics, 28, 461 466.
13. KuKanich, B., Lascelles, B.D. Papich, M.G. (2005b) Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs. American Journal of Veterinary Research, 66, 1968 1974.
14. KuKanich, B., Lascelles, B.D. Papich, M.G. (2005c) Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs. Journal of Veterinary Pharmacology and Therapeutics, 28, 371 376.
15. KuKanich, B., Hogan, B.K., Krugner-Higby, L.A. Smith, L.J. (2008a) Pharmacokinetics of hydromorphone hydrochloride in healthy dogs. Veterinary Anaesthesia and Analgesia, 35, 256 264.
16. KuKanich, B., Schmidt, B.K., Krugner-Higby, L.A., Toerber, S. Smith, L.J. (2008b) Pharmacokinetics and behavioral effects of oxymorphone after intravenous and subcutaneous administration to healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 31, 580 583.
17. Lötsch, J., Skarke, C., Schmidt, H., Rohrbacher, M., Hofmann, U., Schwab, M. Geisslinger, G. (2006) Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites. Clinical Pharmacology and Therapeutics., 79, 35 48.
18. McMillan, C.J., Livingston, A., Clark, C.R., Dowling, P.M., Taylor, S.M., Duke, T. Terlinden, R. (2008) Pharmacokinetics of intravenous tramadol in dogs. Canadian Journal of Veterinary Research, 72, 325 331.
19. Mills, P.C. (2003) A model to investigate hepatic extraction of oxygen during anaesthesia in the dog. Research in Veterinary Science, 75, 179 183.
20. Pickering, G., Loriot, M.A., Libert, F., Eschalier, A., Beaune, P. Dubray, C. (2006) Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clinical Pharmacology and Therapeutics, 79, 371 378.
21. Savides, M.C., Oehme, F.W., Nash, S.L. Leipold, H.W. (1984) The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicology and Applied Pharmacology, 15, 74.
22. Skingle, M. Tyers, M.B. (1980) Further studies on opiate receptors that mediate antinoception: tooth pulp stimulation in the dog. British Journal of Pharmacology, 70, 323 327.
23. Srinivasan, V., Wielbo, D. Tebbett, I.R. (1997) Analgesic effects of codeine-6-glucuronide after intravenous administration. European Journal of Pain, 1, 185 190.
24. Vettorato, E., Zonca, A., Isola, M., Villa, R., Gallo, M., Ravasio, G., Beccaglia, M., Montesissa, C. Cagnardi, P. (2009) Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs. The Veterinary Journal E PUB, in press).
25. Weinstein, S.H. Gaylord, J.C. (1979) Determination of oxycodone in plasma and identification of a major metabolite. Journal of Pharmaceutical Sciences, 68, 527 528.
26. Yoshimura, K., Horiuchi, M., Konishi, M. Yamamoto, K. (1993) Physical dependence on morphine induced in dogs via the use of miniosmotic pumps. Journal of Pharmacological Toxicological Methods, 30, 85 95.