Downregulation of antigen-presenting cells in tonsil and lymph nodes of porcine reproductive and respiratory syndrome virus-infected pigs

Transboundary and Emerging Diseases

Volumn 60, Issue 5, 2013, Pages 425-437

  Rodriguez Gomez I M ^a   Gomez Laguna J ^a,d   Barranco, I ^a   Pallares F J ^b   Ramis, G ^b   Salguero, F J ^c   Carrasco, L ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c VETERINARY LABORATORIES AGENCY   (United Kingdom)

^d CICAP   (Spain)

Author keywords

Antigen presenting cells; Lymph nodes; Porcine reproductive and respiratory syndrome virus; T cells; Tonsil

Indexed keywords

ARTERIVIRUS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

HLA DR ANTIGEN; VIRUS ANTIGEN;

ANIMAL; ANTIGEN PRESENTING CELL; ARTERIVIRUS; ARTICLE; B LYMPHOCYTE; DOWN REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE COUNT; MACROPHAGE; MEDIASTINUM; PALATINE TONSIL; PHARYNX; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; SWINE; T LYMPHOCYTE; TONSIL;

ANTIGEN-PRESENTING CELLS; LYMPH NODES; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; T CELLS; TONSIL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, VIRAL; B-LYMPHOCYTES; DOWN-REGULATION; HLA-DR ANTIGENS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHOCYTE COUNT; MACROPHAGES; MEDIASTINUM; PALATINE TONSIL; PHARYNX; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUS SCROFA; SWINE; T-LYMPHOCYTES;

EID: 84883656044     PISSN: 18651674     EISSN: 18651682     Source Type: Journal    
DOI: 10.1111/j.1865-1682.2012.01363.x     Document Type: Article

References (52)

1. Ahn, K., A. Angulo, P. Ghazal, P. A. Peterson, Y. Yang, and K. Früh, 1996: Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc. Natl. Acad. Sci. USA93, 10990-10995.
2. Albina, E., F. Madec, R. Cariolet, and J. Torrison, 1994: Immune response and persistence of the porcine reproductive and respiratory syndrome virus in infected pigs and farm units. Vet. Rec.134, 567-573.
3. Álvarez, B., C. Sánchez, R. Bullido, A. Marina, J. Lunney, F. Alonso, A. Ezquerra, and J. Dominguez, 2000: A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with proteine tyrosine phosphatase SHP-1. Tissue Antigens55, 342-351.
4. Andrews, D. M., C. E. Andoniou, F. Granucci, P. Ricciardi-Castagnoli, and M. A. Degli-Esposti, 2001: Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat. Immunol.2, 1077-1084.
5. Banchereau, J., and R. M. Steinman, 1998: Dendritic cells and the control of immunity. Nature392, 245-252.
6. Batista, L., C. Pijoan, S. Dee, M. Olin, T. Molitor, H. S. Joo, Z. Xiao, and M. Murtaugh, 2004: Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts. Can. J. Vet. Res.68, 267-273.
7. Carrasco, C. P., R. C. Rigden, I. E. Vincent, C. Balmelli, M. Ceppi, O. Bauhofer, V. Tache, B. Hjertner, F. McNeilly, H. G. van Gennip, K. C. McCullough, and A. Summerfield, 2004: Interaction of classical swine fever virus with dendritic cells. J. Gen. Virol.85, 1633-1641.
8. Chang, H. C., Y. T. Peng, H. L. Chaung, and W. B. Chung, 2008: Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus. Vet. Microbiol.129, 281-293.
9. Charerntantanakul, W., R. Platt, and J. Roth, 2006: Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T Cell activation and antiviral cytokine production. Viral Immunol.19, 646-661.
10. Chiou, M. T., C. R. Jeng, L. L. Chueh, C. H. Cheng, and V. F. Pang, 2000: Effects of porcine reproductive and respiratory syndrome virus (isolate tw91) on porcine alveolar macrophages in vitro. Vet. Microbiol.71, 9-25.
11. Choi, C., W. S. Cho, B. Kim, and C. Chae, 2002: Expression of Interferon-gamma and tumour necrosis factor-alpha in pigs experimentally infected with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). J. Comp. Pathol.127, 106-113.
12. Díaz, I., L. Darwich, G. Pappaterra, J. Pujols, and E. Mateu, 2005: Immune responses of pigs after experimental infection with a European strain of porcine reproductive and respiratory syndrome virus. J. Gen. Virol.86, 1943-1951.
13. Domenech, N., M. P. Rodríguez-Carreño, P. Filgueira, B. Álvarez, S. Chamorro, and J. Domínguez, 2003: Identification of porcine macrophages with monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. Vet. Immunol. Immunopathol.94, 77-81.
14. Done, S. H., and D. J. Paton, 1995: Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet. Rec.136, 32-35.
15. Fauquet, C. M., M. A. Mayo, J. Maniloff, U. Desselberger, and L. A. Ball, 2005: Virus taxonomy, clasiffication and nomenclature of viruses. In: Fauquet, C. M., M. A. Mayo, J. Maniloff, U. Desselberger, and L. A. Ball (eds), 8th ICTV Report of the International Committee on Taxonomy of Viruses, p. 1259. Elsevier Academic Press, London.
16. Flores-Mendoza, L., E. Silva-Campa, M. Reséndiz, F. A. Osorio, and J. Hernández, 2008: Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production. Clin. Vaccine Immunol.15, 720-725.
17. Gimeno, M., L. Darwich, I. Díaz, E. de la Torre, J. Pujols, M. Martín, S. Inumaru, E. Cano, M. Domingo, M. Montoya, and E. Mateu, 2011: Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates. Vet. Res.42, 9.
18. high. Viral Immunol.22, 261-271.
19. Gómez-Lucía, E., M. M. Blanco, and A. Doménech, 2007: Células implicadas en la respuesta inmune. In: Gómez-Lucía, E., M. M. Blanco, and A. Doménech (eds), Manual de Inmunología Veterinaria, 1st edn, pp. 41-62. Pearsom-Prentice Hall, Madrid.
20. Halbur, P. G., P. S. Paul, and M. L. Frey, 1995: Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol.32, 648-660.
21. Harding, C. V., and L. Ramachandra, 2010: Presenting exogenous antigen to T cells. Curr. Protocol Immunol.88, Chapter 16, unit 16: 2, 16.2.1-16.2-18.
22. Haynes, J. S., P. G. Halbur, T. Sirinarumitr, P. S. Paul, J. X. Meng, and E. L. Huffman, 1997: Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence. Vet. Pathol.34, 39-43.
23. Kumar, V., A. K. Abbas, N. Fausto, and J. C. Aster, 2010. Diseases of the immune system. In: Kumar, V., A. K. Abbas, N. Fausto, and J. C. Aster (eds), Robbins and Cotran, Pathologic Basis of Disease, 8th edn, pp. 183-258. Elsevier Science, Philadelphia.
24. Liu, Y. J., G. Grouard, O. de Bouteiller, and J. Banchereau, 1996: Follicular dendritic cells and germinal centers. Int. Rev. Cytol.166, 139-179.
25. Loemba, H. D., S. Mounir, H. Mardassi, D. Archambault, and S. Dea, 1996: Kinetics of humoral immune response to the major structural proteins of the porcine reproductive and respiratory syndrome virus. Arch. Virol.141, 751-761.
26. Loving, C. L., S. L. Brockmeier, and R. E. Sacco, 2007: Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology120, 217-229.
27. Mateu, E., I. Díaz, L. Darwich, J. Casal, M. Martín, and J. Pujols, 2006: Evolution of ORF5 of Spanish porcine reproductive and respiratory syndrome virus strains from 1991 to 2005. Virus Res.115, 198-206.
28. Meier, W. A., J. Galeota, F. A. Osorio, R. J. Husmann, W. M. Schnitzlein, and F. A. Zuckermann, 2003: Gradual development of the interferon-γ response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virology309, 18-31.
29. Meulenberg, J. J., M. M. Hulst, E. J. de Meijer, P. L. Moonen, A. den Besten, E. P. de Kluyver, G. Wensvoort, and R. J. Moormann, 1993: Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology192, 62-72.
30. Mulupuri, P., J. J. Zimmerman, J. Hermann, C. R. Johnson, J. P. Cano, W. Yu, S. A. Dee, and M. P. Murtaugh, 2008: Antigen-specific B-cell responses to porcine reproductive and respiratory syndrome virus infection. J. Virol.82, 358-370.
31. Neumann, E. J., J. B. Kliebenstein, C. D. Johnson, J. W. Mabry, E. J. Bush, A. H. Seitzinger, A. L. Green, and J. J. Zimmerman, 2005: Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J. Am. Vet. Med. Assoc.227, 385-392.
32. Pérez, J., P. M. García, E. Mozos, M. J. Bautista, and L. Carrasco, 2001: Immunohistochemical characterization of hepatic lesions associated with migrating larvae of Ascaris suum in pigs. J. Comp. Pathol.124, 200-206.
33. Ramos, J. A., A. J. Ramis, A. Marco, M. Domingo, R. Rabanal, and L. Ferrer, 1992: Histochemical and immunohistochemical study of the mucosal lymphoid system in swine. Am. J. Vet. Res.53, 1418-1426.
34. Rossow, K. D., J. E. Collins, S. M. Goyal, E. A. Nelson, J. Christopher-Hennings, and D. A. Benfield, 1995: Pathogenesis of porcine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Vet. Pathol.32, 361-373.
35. Salguero, F. J., P. J. Sánchez-Cordón, A. Núñez, M. Fernández de Marco, and J. C. Gómez-Villamandos, 2005: Proinflammatory cytokines induce lymphocyte apoptosis in acute African swine fever infection. J. Comp. Pathol.132, 289-302.
36. Salio, M., M. Cella, M. Suter, and A. Lanzavecchia, 1999: Inhibition of dendritic cell maturation by herpes simplex virus. Eur. J. Immunol.29, 3245-3253.
37. Sevilla, N., S. Kunz, A. Holz, H. Lewicki, D. Homman, H. Yamada, K. P. Campbell, J. C. de La Torre, and M. B. Oldstone, 2000: Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J. Exp. Med.192, 1249-1260.
38. Silva-Campa, E., L. Cordoba, L. Fraile, L. Flores-Mendoza, M. Montoya, and J. Hernández, 2010: European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells. Virology396, 264-271.
39. Suárez, P., M. Díaz-Guerra, C. Prieto, M. Esteban, J. M. Castro, A. Nieto, and J. Ortin, 1996: Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis. J. Virol.70, 2876-2882.
40. Takikawa, N., S. Kobayashi, S. Ide, Y. Yamane, Y. Tanaka, and H. Yamagishi, 1996: Detection of antibodies against porcine reproductive and respiratory syndrome (PRRS) virus in swine sera by enzyme-linked immunosorbent assay. J. Vet. Med. Sci.58, 355-357.
41. Tanimoto, T., and Y. Ohtsuki, 1996: Evaluation of antibodies reactive with porcine lymphocytes and lymphoma cells in formalin-fixed, paraffin-embedded, antigen-retrieved tissue sections. Am. J. Vet. Res.57, 853-859.
42. Thanawongnuwech, R., G. B. E. L. Thacker, and P. G. Halbur, 1997: Effect of Porcine reproductive and respiratory syndrome virus (PRRSV) (isolate ATCC VR-2385) infection on bactericidal activity of porcine pulmonary intravascular macrophages (PIMs): in vitro comparisons with pulmonary alveolar macrophages (PAMs). Vet. Immunol. Immunopathol.59, 323-335.
43. Thanawongnuwech, R., G. B. Brown, P. G. Halbur, J. A. Roth, R. L. Royer, and B. J. Thacker, 2000: Pathogenesis of porcine reproductive and respiratory syndrome virus-induced increase in susceptibility to Streptococcus suis infection. Vet. Pathol.37, 143-152.
44. Tingstedt, J. E., D. Torrehave, P. Lind, and J. Nielsen, 2003: Immunohistochemical detection of SWC3, CD2, CD3, CD4 and CD8 antigens in paraformaldehyde fixed and paraffin embedded porcine lymphoid tissue. Vet. Immunol. Immunopathol.94, 123-132.
45. Tizard, I. R., 2009: Dendritic cells and antigen processing. In: Tizard, I. R. (eds), Veterinary Immunology, 7th edn, pp. 56-66. Saunders Editorial, Philadelphia.
46. Villamide-Herrera, L., R. Ignatius, M. A. Eller, K. Wilkinson, C. Griffin, E. Mehlhop, J. Jones, S. Y. Han, M. G. Lewis, S. Parrish, T. C. Vancott, J. D. Lifson, S. Schlesinger, J. R. Mascola, and M. Pope, 2004: Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo. AIDS Res. Hum. Retrovir.20, 871-884.
47. Vincent, I. E., C. P. Carrasco, B. Herrmann, B. M. Meehan, G. M. Allan, A. Summerfield, and K. C. McCullough, 2003: Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J. Virol.77, 13288-13300.
48. Wang, X., M. Eaton, M. Mayer, H. Li, D. He, E. Nelson, and J. Christopher-Hennings, 2007: Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch. Virol.152, 289-303.
49. Wensvoort, G., C. Terpstra, J. M. Pol, E. A. ter Laak, M. Bloemraad, E. P. de Kluyver, C. Kragten, L. van Buiten, A. den Besten, F. Wagenaar, J. M. Broekhuijsen, P. L. Moonen, T. Zetstra, E. A. de Boer, H. J. Tibben, M. F. de Jong, P. van't Veld, G. J. R. Greenland, J. A. van Gennep, M. T. Voets, J. H. M. Verheijden and J. Braamskamp, 1991: Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Q.13, 121-130.
50. Xu, M., W. Shujie, L. Li, L. Lei, Y. Liu, W. Shi, J. Wu, L. Li, F. Rong, M. Xu, G. Sun, H. Xiang, and X. Cai, 2010: Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs. Virol. J.7, 184.
51. Yoon, I. J., H. S. Joo, S. M. Goyal, and T. W. Molitor, 1994: A modified serum neutralization test for the detection of antibody to porcine reproductive and respiratory syndrome virus in swine sera. J. Vet. Diagn. Invest.6, 289-292.
52. Zeman, D., R. Neiger, M. Yaeger, E. Nelson, D. Benfield, P. Leslie-Steen, J. Thomson, D. Miskimins, R. Daly, and M. Minehart, 1993: Laboratory investigation or PRRS virus infection in three swine herds. J. Vet. Diagn. Invest.5, 522-528.