The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: Evidence from a longitudinal twin study

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 54, Issue 10, 2013, Pages 1066-1073

  Chen, Jie ^a   Li, Xinying ^a   McGue, Matt ^b  

^a INSTITUTE OF PSYCHOLOGY   (China)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Adolescent; BDNF Val66Met polymorphism; depressive symptoms; gene environment correlation; gene environment interaction; stressful life events

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADOLESCENT; CHILD; CHINA; COMPARATIVE STUDY; DEPRESSION; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LIFE EVENT; MALE; PREDICTIVE VALUE; PROSPECTIVE STUDY; TWINS; ARTICLE; BDNF VAL66MET POLYMORPHISM; DEPRESSIVE SYMPTOMS; GENE-ENVIRONMENT CORRELATION; STRESSFUL LIFE EVENTS;

ADOLESCENT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHINA; DEPRESSION; DISEASES IN TWINS; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; LIFE CHANGE EVENTS; MALE; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES;

ADOLESCENT; BDNF VAL66MET POLYMORPHISM; DEPRESSIVE SYMPTOMS; GENE-ENVIRONMENT CORRELATION; GENE-ENVIRONMENT INTERACTION; STRESSFUL LIFE EVENTS;

EID: 84883655722     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/jcpp.12099     Document Type: Article

References (49)

1. Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H.,. &, Ortet, G., (2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425-1432.
2. Alexander, N., Osinsky, R., Schmitz, A., Mueller, E., Kuepper, Y., &, Hennig, J., (2010). The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress. Psychoneuroendocrinology, 35, 949-953.
3. Åslund, C., Leppert, J., Comasco, E., Nordquist, N., Oreland, L., &, Nilsson, K.W., (2009). Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study. Behavior Genetics, 39, 524-531.
4. Benjet, C., Thompson, R.J., &, Gotlib, I.H., (2010). 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls. Journal of Child Psychology and Psychiatry, 51, 173-179.
5. Berton, O., McClung, C.A., Dileone, R.J., Krishan, V., Russo, S.J., Graham, D.,. &, Rios, M., (2006). Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science, 311, 864-868.
6. Carver, C.S., Johnson, S.L., Joormann, J., LeMoult, J., &, Cuccaro, M.L., (2011). Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of Affective Disorders, 132, 89-93.
7. Chen, J., Li, X., Chen, Z., Yang, X., Zhang, J., Duan, Q., &, Ge, X., (2010). Optimization of zygosity determination by questionnaire and DNA genotyping in Chinese adolescent twins. Twin Research and Human Genetics, 2, 194-200.
8. Chen, J., Li, X., &, McGue, M., (2012). Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. Genes, Brain and Behavior, 11, 958-965.
9. Chen, J., Li, X., Zhang, J., Natsuaki, M.N., Leve, L.D., Harold, G.T.,. &, Zhang, J., (2013). The Beijing Twin Study (BeTwist): A longitudinal study of child and adolescent development. Twin Research and Human Genetics, 16, 91-97.
10. Chen, X., Liu, M., &, Li, D., (2000). Parental warmth, control, and indulgence and their relations to adjustment in Chinese children: A longitudinal study. Journal of Family Psychology, 14, 401-419.
11. Cole, D.A., &, Martin, N.C., (2005). The longitudinal structure of the Children's Depression Inventory: Testing a latent trait-state model. Psychological Assessment, 17, 144-155.
12. Dunn, E.C., Uddin, M., Subramanian, S.V., Smoller, J.W., Galea, S., &, Koenen, K.C., (2011). Gene-envionrment interaction research in youth depression-a systematic review with recommendations for future research. Journal of Child Psychology and Psychiatry, 52, 1223-1238.
13. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A.,. &, Dean, M., (2003). The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-270.
14. Eisch, A.J., Bolaños, C.A., de Wit, J., Simonak, R.D., Pudiak, C.M., Barrot, M.,. &, Nestler, E.J., (2003). Brain-derived neuotrophic factor in the ventral midbrain-nucleus accumbens pathway: A role in depression. Biological Psychiatry, 54, 994-1005.
15. Enders, C.K., (2001). A primer on maximum likelihood algorithms available for use with missing data. Structural Equation Modeling, 8, 128-141.
16. Gatt, J.M., Nemeroff, C.B., Dobson-Stone, C., Paul, R.H., Bryant, R.A., Schofield, P.R.,. &, Williams, L.M., (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14, 681-695.
17. Graham, J.W., (2009). Missing data analysis: Making it work in the real world. Annual Review of Psychology, 60, 549-576.
18. Greenberg, M.E., Xu, B., Lu, B., &, Hempstead, B.L., (2009). New insights in the biology of BDNF synthesis and release: Implications in CNS function. The Journal of Neuroscience, 29, 12764-12767.
19. Hajcak, G., Castille, C., Olvet, D., Dunning, J., Roohi, J., &, Hatchwell, E., (2009). Genetic variation in brain-derived neurotrophic factor and human fear conditioning. Genes, Brain and Behavior, 8, 80-85.
20. Jaffee, S.R., &, Price, T., (2007). Gene-environment correlations: A review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12, 432-442.
21. Johnson, J.H., &, McCutcheon, S.M., (1980). Assessing life stress in older children and adolescents: Preliminary findings with the life events checklist. In, I.G. Sarason, &, C.C. Spielberger, (Eds.), Stress and anxiety (pp. 111-125). Washington, DC: Hemisphere.
22. Karg, K., Burmeister, M., Shedden, K., &, Sen, S., (2011). The serotonin transporter promoter variation (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454.
23. Kovacs, M., &, Staff, M., (2003). Children's Depression Inventory (CDI): Technical manual update. North Tonawanda, NY, USA: Multi-Health Systems. Inc.
24. Krishnan, V., Han, M.H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J.,. &, Lagace, D.C., (2007). Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell, 131, 391-404.
25. Krueger, R.F., Markon, K.E., &, Bouchard, T.J., (2003). The extended genotype: The heritability of personality accounts for the heritability of recalled family environments in twins reared apart. Journal of Personality, 71, 809-833.
26. Kumsta, R., Stevens, S., Brookes, K., Schlotz, W., Castle, J., Beckett, C.,. &, Sonuga-Barke, E., (2010). 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: Evidence from the English and Romanian Adoptee study. Journal of Child Psychology and Psychiatry, 51, 755-762.
27. Lenroot, R.K., &, Giedd, J.N., (2011). Developmental considerations of gene by enivronment interactions. Journal of Child Psychology and Psychiatry, 52, 429-441.
28. Liu, R.T., &, Alloy, L.B., (2010). Stress generation in depression: A systematic review of the empirical literature and recommendations for future study. Clinical Psychology Review, 30, 582-593.
29. Lonsdorf, T.B., Weike, A.I., Golkar, A., Schalling, M., Hamm, A.O., &, Öhman, A., (2010). Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism. Behavioral Neuroscience, 124, 9-15.
30. Lu, B., (2003). BDNF and activity-dependent synpatic modulation. Learning & Memory, 10, 86-98.
31. Lu, B., &, Figurov, A., (1997). Role of neurotrophins in synpase development and plasticity. Review of Neuroscience, 8, 1-12.
32. Lu, B., Pang, P.T., &, Woo, N.H., (2005). The yin and yang of neurotrophin action. Nature Reviews Neuroscience, 6, 603-614.
33. Lupien, S.J., McEwen, B.S., Gunnar, M.R., &, Heim, C., (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience, 10, 434-445.
34. Martinowich, K., Manji, H., &, Lu, B., (2007). New insights into BDNF function in depression and anxiety. Nature Neuroscience, 10, 1089-1093.
35. Moffitt, T.E., Caspi, A., &, Rutter, M., (2006). Measured Gene-Environment Interactions in Psychopathology Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. Perspectives on Psychological Science, 1, 5-27.
36. Monroe, S.M., (2008). Modern approaches to conceptualizing and measuring human life stress. Annual Review of Clinical Psychology, 4, 33-52.
37. Neale, M.C., Boker, S.M., Xie, G., &, Maes, H.H., (2003). Mx: Statistical modeling. Richmond, VA: Department of Psychiatry. Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University.
38. Nestler, E.J., &, Carlezon, W.A., (2006). The mesolimbic depamine reward circuit in depression. Biological Psychiatry, 59, 1151-1159.
39. Petryshen, T.L., Sabeti, P.C., Aldinger, K.A., Fry, B., Fan, J.B., Schaffner, S.F.,. &, Sklar, P., (2009). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry, 15, 810-815.
40. Rao, U., Chen, L.A., Bidesi, A.S., Shad, M.U., Thomas, M.A., &, Hammen, C.L., (2010). Hippocampal changes associated with early-life adversity and vulnerability to depression. Biological Psychiatry, 67, 367-364.
41. Rudolph, K.D., Flynn, M., Abaied, J.L., Groot, A., &, Thompson, R., (2009). Why is past depression the best predictor of future depression? Stress generation as a mechanism of depression continuity in girls. Journal of Clinical Child & Adolescent Psychology, 38, 473-485.
42. Rutter, M., &, Silberg, J., (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53, 463-490.
43. Shalev, I., Lerer, E., Israel, S., Uzefovsky, F., Gritsenko, I., Mankuta, D.,. &, Kaitz, M., (2009). BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. Psychoneuroendocrinology, 34, 382-388.
44. Silberg, J., Pickles, A., Rutter, M., Hewitt, J., Simonoff, E., Maes, H.,. &, Eaves, L., (1999). The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry, 56, 225-232.
45. Turner, D., Choudhury, F., Reynard, M., Railton, D., &, Navarrete, C., (2002). Typing of multiple single nucleotide polymorphisms in cytokine and receptor genes using SNaPshot. Human Immunology, 63, 508-513.
46. Verhagen, M., Van Der Meij, A., Van Deurzen, P.A.M., Janzing, J.G.E., Arias-Vasquez, A., Buitelaar, J.K., &, Franke, B., (2010). Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicity. Molecular Psychiatry, 15, 260-271.
47. Wagner, C., Abela, J.R.Z., &, Brozina, K., (2006). A comparison of stress measures in children and adolescents: A self-report checklist versus an objectively rated interview. Journal of Psychopathology and Behavioral Assessment, 28, 250-260.
48. Wang, Z., Li, Z., Chen, J., Huang, J., Yuan, C., Hong, W.,. &, Fang, Y., (2012). Association of BDNF gene Polymorphism with bipolar disorders in Han Chinese population. Genes, Brain, and Behavior, 11, 524-528.
49. Wichers, M., Kenis, G., Jacobs, N., Mengelers, R., Derom, C., Vlietinck, R., &, van Os, J., (2008). The BDNF Val66Met× 5-HTTLPR× child adversity interaction and depressive symptoms: An attempt at replication. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147, 120-123.