메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

Estradiol and Tamoxifen Induce Cell Migration through GPR30 and Activation of Focal Adhesion Kinase (FAK) in Endometrial Cancers with Low or without Nuclear Estrogen Receptor α (ERα)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FOCAL ADHESION KINASE; G PROTEIN COUPLED RECEPTOR 30; HYDROXYTAMOXIFEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE;

EID: 84883645377     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072999     Document Type: Article
Times cited : (56)

References (51)
  • 3
    • 1242300083 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
    • Strom A, Hartman J, Foster JS, Kietz S, Wimalasena J, et al. (2004) Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A 101: 1566-1571.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1566-1571
    • Strom, A.1    Hartman, J.2    Foster, J.S.3    Kietz, S.4    Wimalasena, J.5
  • 5
    • 25144483917 scopus 로고    scopus 로고
    • GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    • Filardo EJ, Thomas P, (2005) GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol Metab 16: 362-367.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 362-367
    • Filardo, E.J.1    Thomas, P.2
  • 6
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo EJ, Quinn JA, Bland KI, Frackelton AR Jr, (2000) Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 14: 1649-1660.
    • (2000) Mol Endocrinol , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton Jr., A.R.4
  • 7
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER, (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307: 1625-1630.
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 8
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • Thomas P, Pang Y, Filardo EJ, Dong J, (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146: 624-632.
    • (2005) Endocrinology , vol.146 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 9
    • 63849242931 scopus 로고    scopus 로고
    • Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice
    • Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, et al. (2009) Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology 150: 1722-1730.
    • (2009) Endocrinology , vol.150 , pp. 1722-1730
    • Isensee, J.1    Meoli, L.2    Zazzu, V.3    Nabzdyk, C.4    Witt, H.5
  • 10
    • 70349401677 scopus 로고    scopus 로고
    • GPR30/GPER1: searching for a role in estrogen physiology
    • Olde B, Leeb-Lundberg LM, (2009) GPR30/GPER1: searching for a role in estrogen physiology. Trends Endocrinol Metab 20: 409-416.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 409-416
    • Olde, B.1    Leeb-Lundberg, L.M.2
  • 11
    • 3042547161 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    • Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, et al. (2004) The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem 279: 27008-27016.
    • (2004) J Biol Chem , vol.279 , pp. 27008-27016
    • Maggiolini, M.1    Vivacqua, A.2    Fasanella, G.3    Recchia, A.G.4    Sisci, D.5
  • 12
    • 67349105361 scopus 로고    scopus 로고
    • Mechanisms of estrogen signaling and gene expression via GPR30
    • Prossnitz ER, Maggiolini M, (2009) Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 308: 32-38.
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 32-38
    • Prossnitz, E.R.1    Maggiolini, M.2
  • 13
    • 33748923143 scopus 로고    scopus 로고
    • 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
    • Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, et al. (2006) 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30. Mol Pharmacol 70: 1414-1423.
    • (2006) Mol Pharmacol , vol.70 , pp. 1414-1423
    • Vivacqua, A.1    Bonofiglio, D.2    Albanito, L.3    Madeo, A.4    Rago, V.5
  • 14
    • 33947697810 scopus 로고    scopus 로고
    • GPR30: a novel indicator of poor survival for endometrial carcinoma
    • discussion 386 e389-311
    • Smith HO, Leslie KK, Singh M, Qualls CR, Revankar CM, et al. (2007) GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol 196: 386 e381-389; discussion 386 e389-311.
    • (2007) Am J Obstet Gynecol , vol.196 , pp. 386-389
    • Smith, H.O.1    Leslie, K.K.2    Singh, M.3    Qualls, C.R.4    Revankar, C.M.5
  • 16
    • 79952119039 scopus 로고    scopus 로고
    • Role of GPR30 in endometrial pathology after tamoxifen for breast cancer
    • Ignatov T, Eggemann H, Semczuk A, Smith B, Bischoff J, et al. (2010) Role of GPR30 in endometrial pathology after tamoxifen for breast cancer. Am J Obstet Gynecol 203: 595 e599-516.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 516-595
    • Ignatov, T.1    Eggemann, H.2    Semczuk, A.3    Smith, B.4    Bischoff, J.5
  • 17
    • 11244258882 scopus 로고    scopus 로고
    • Focal adhesion kinase: in command and control of cell motility
    • Mitra SK, Hanson DA, Schlaepfer DD, (2005) Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 56-68
    • Mitra, S.K.1    Hanson, D.A.2    Schlaepfer, D.D.3
  • 18
    • 33748992582 scopus 로고    scopus 로고
    • Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding
    • Robles E, Gomez TM, (2006) Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat Neurosci 9: 1274-1283.
    • (2006) Nat Neurosci , vol.9 , pp. 1274-1283
    • Robles, E.1    Gomez, T.M.2
  • 19
    • 33846554255 scopus 로고    scopus 로고
    • Focal adhesion kinase: a potential target in cancer therapy
    • van Nimwegen MJ, van de Water B, (2007) Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol 73: 597-609.
    • (2007) Biochem Pharmacol , vol.73 , pp. 597-609
    • van Nimwegen, M.J.1    van de Water, B.2
  • 20
    • 0041369959 scopus 로고    scopus 로고
    • FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
    • Miyazaki T, Kato H, Nakajima M, Sohda M, Fukai Y, et al. (2003) FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 89: 140-145.
    • (2003) Br J Cancer , vol.89 , pp. 140-145
    • Miyazaki, T.1    Kato, H.2    Nakajima, M.3    Sohda, M.4    Fukai, Y.5
  • 21
    • 0036632633 scopus 로고    scopus 로고
    • Estrogen and cancer
    • Creasman WT, (2002) Estrogen and cancer. Gynecol Oncol 86: 1-9.
    • (2002) Gynecol Oncol , vol.86 , pp. 1-9
    • Creasman, W.T.1
  • 22
    • 77954506419 scopus 로고    scopus 로고
    • Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways
    • Lepine J, Audet-Walsh E, Gregoire J, Tetu B, Plante M, et al. (2010) Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways. J Clin Endocrinol Metab 95: 2689-2698.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2689-2698
    • Lepine, J.1    Audet-Walsh, E.2    Gregoire, J.3    Tetu, B.4    Plante, M.5
  • 23
    • 78751567896 scopus 로고    scopus 로고
    • Estrogen regulates endometrial cell cytoskeletal remodeling and motility via focal adhesion kinase
    • Flamini MI, Sanchez AM, Genazzani AR, Simoncini T, (2011) Estrogen regulates endometrial cell cytoskeletal remodeling and motility via focal adhesion kinase. Fertil Steril 95: 722-726.
    • (2011) Fertil Steril , vol.95 , pp. 722-726
    • Flamini, M.I.1    Sanchez, A.M.2    Genazzani, A.R.3    Simoncini, T.4
  • 24
    • 0020985062 scopus 로고
    • Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture
    • Way DL, Grosso DS, Davis JR, Surwit EA, Christian CD, (1983) Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture. In Vitro 19: 147-158.
    • (1983) In Vitro , vol.19 , pp. 147-158
    • Way, D.L.1    Grosso, D.S.2    Davis, J.R.3    Surwit, E.A.4    Christian, C.D.5
  • 25
    • 0021865277 scopus 로고
    • Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors
    • Nishida M, Kasahara K, Kaneko M, Iwasaki H, Hayashi K, (1985) [Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors]. Nippon Sanka Fujinka Gakkai Zasshi 37: 1103-1111.
    • (1985) Nippon Sanka Fujinka Gakkai Zasshi , vol.37 , pp. 1103-1111
    • Nishida, M.1    Kasahara, K.2    Kaneko, M.3    Iwasaki, H.4    Hayashi, K.5
  • 26
    • 67649099360 scopus 로고    scopus 로고
    • Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes
    • Wang TH, Chao AS, Chen JK, Chao A, Chang YL, et al. (2009) Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes. Fertil Steril 92: 96-107.
    • (2009) Fertil Steril , vol.92 , pp. 96-107
    • Wang, T.H.1    Chao, A.S.2    Chen, J.K.3    Chao, A.4    Chang, Y.L.5
  • 27
    • 77956498726 scopus 로고    scopus 로고
    • Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation
    • Wang TH, Chao A, Tsai CL, Chang CL, Chen SH, et al. (2010) Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation. Mol Cell Proteomics 9: 1873-1884.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1873-1884
    • Wang, T.H.1    Chao, A.2    Tsai, C.L.3    Chang, C.L.4    Chen, S.H.5
  • 28
    • 84856960678 scopus 로고    scopus 로고
    • Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2
    • Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, et al. (2012) Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2. Oncogene 31: 764-775.
    • (2012) Oncogene , vol.31 , pp. 764-775
    • Chao, A.1    Lin, C.Y.2    Lee, Y.S.3    Tsai, C.L.4    Wei, P.C.5
  • 29
    • 84865788598 scopus 로고    scopus 로고
    • Secreted stress-induced phosphoprotein 1 activates the ALK2-SMAD signaling pathways and promotes cell proliferation of ovarian cancer cells
    • Tsai CL, Tsai CN, Lin CY, Chen HW, Lee YS, et al. (2012) Secreted stress-induced phosphoprotein 1 activates the ALK2-SMAD signaling pathways and promotes cell proliferation of ovarian cancer cells. Cell Rep 2: 283-293.
    • (2012) Cell Rep , vol.2 , pp. 283-293
    • Tsai, C.L.1    Tsai, C.N.2    Lin, C.Y.3    Chen, H.W.4    Lee, Y.S.5
  • 30
    • 33646504879 scopus 로고    scopus 로고
    • Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression
    • Chao A, Wang TH, Lee YS, Hsueh S, Chao AS, et al. (2006) Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression. Int J Cancer 119: 91-98.
    • (2006) Int J Cancer , vol.119 , pp. 91-98
    • Chao, A.1    Wang, T.H.2    Lee, Y.S.3    Hsueh, S.4    Chao, A.S.5
  • 31
    • 47949111993 scopus 로고    scopus 로고
    • Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
    • Albanito L, Sisci D, Aquila S, Brunelli E, Vivacqua A, et al. (2008) Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. Endocrinology 149: 3799-3808.
    • (2008) Endocrinology , vol.149 , pp. 3799-3808
    • Albanito, L.1    Sisci, D.2    Aquila, S.3    Brunelli, E.4    Vivacqua, A.5
  • 32
    • 77949873402 scopus 로고    scopus 로고
    • Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma
    • Chao A, Tsai CL, Wei PC, Hsueh S, Chao AS, et al. (2010) Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Cancer Lett 291: 99-107.
    • (2010) Cancer Lett , vol.291 , pp. 99-107
    • Chao, A.1    Tsai, C.L.2    Wei, P.C.3    Hsueh, S.4    Chao, A.S.5
  • 33
    • 33745186178 scopus 로고    scopus 로고
    • The signaling and biological implications of FAK overexpression in cancer
    • Siesser PM, Hanks SK, (2006) The signaling and biological implications of FAK overexpression in cancer. Clin Cancer Res 12: 3233-3237.
    • (2006) Clin Cancer Res , vol.12 , pp. 3233-3237
    • Siesser, P.M.1    Hanks, S.K.2
  • 34
    • 57349153946 scopus 로고    scopus 로고
    • A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
    • Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, et al. (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem 51: 7405-7416.
    • (2008) J Med Chem , vol.51 , pp. 7405-7416
    • Golubovskaya, V.M.1    Nyberg, C.2    Zheng, M.3    Kweh, F.4    Magis, A.5
  • 35
    • 34249798185 scopus 로고    scopus 로고
    • FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway
    • Thamilselvan V, Craig DH, Basson MD, (2007) FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 21: 1730-1741.
    • (2007) FASEB J , vol.21 , pp. 1730-1741
    • Thamilselvan, V.1    Craig, D.H.2    Basson, M.D.3
  • 36
    • 0036127836 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    • Filardo EJ, (2002) Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J Steroid Biochem Mol Biol 80: 231-238.
    • (2002) J Steroid Biochem Mol Biol , vol.80 , pp. 231-238
    • Filardo, E.J.1
  • 37
    • 62049084027 scopus 로고    scopus 로고
    • Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
    • Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, et al. (2009) Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J 28: 523-532.
    • (2009) EMBO J , vol.28 , pp. 523-532
    • Pandey, D.P.1    Lappano, R.2    Albanito, L.3    Madeo, A.4    Maggiolini, M.5
  • 38
    • 33746031475 scopus 로고    scopus 로고
    • An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling
    • Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, et al. (2006) An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol 174: 277-288.
    • (2006) J Cell Biol , vol.174 , pp. 277-288
    • Pirone, D.M.1    Liu, W.F.2    Ruiz, S.A.3    Gao, L.4    Raghavan, S.5
  • 39
    • 53249107839 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol
    • Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, et al. (2008) G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology 149: 4846-4856.
    • (2008) Endocrinology , vol.149 , pp. 4846-4856
    • Otto, C.1    Rohde-Schulz, B.2    Schwarz, G.3    Fuchs, I.4    Klewer, M.5
  • 40
    • 50649101049 scopus 로고    scopus 로고
    • Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors
    • Madak-Erdogan Z, Kieser KJ, Kim SH, Komm B, Katzenellenbogen JA, et al. (2008) Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol Endocrinol 22: 2116-2127.
    • (2008) Mol Endocrinol , vol.22 , pp. 2116-2127
    • Madak-Erdogan, Z.1    Kieser, K.J.2    Kim, S.H.3    Komm, B.4    Katzenellenbogen, J.A.5
  • 41
    • 33747841976 scopus 로고    scopus 로고
    • Nature of functional estrogen receptors at the plasma membrane
    • Pedram A, Razandi M, Levin ER, (2006) Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol 20: 1996-2009.
    • (2006) Mol Endocrinol , vol.20 , pp. 1996-2009
    • Pedram, A.1    Razandi, M.2    Levin, E.R.3
  • 42
    • 0036721112 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells
    • Ahola TM, Manninen T, Alkio N, Ylikomi T, (2002) G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells. Endocrinology 143: 3376-3384.
    • (2002) Endocrinology , vol.143 , pp. 3376-3384
    • Ahola, T.M.1    Manninen, T.2    Alkio, N.3    Ylikomi, T.4
  • 43
    • 14544270313 scopus 로고    scopus 로고
    • Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study
    • Swerdlow AJ, Jones ME, (2005) Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study. J Natl Cancer Inst 97: 375-384.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 375-384
    • Swerdlow, A.J.1    Jones, M.E.2
  • 44
    • 0030890978 scopus 로고    scopus 로고
    • Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo
    • Moorthy B, Sriram P, Randerath E, Randerath K, (1997) Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. Biochem Pharmacol 53: 663-669.
    • (1997) Biochem Pharmacol , vol.53 , pp. 663-669
    • Moorthy, B.1    Sriram, P.2    Randerath, E.3    Randerath, K.4
  • 45
    • 0033859582 scopus 로고    scopus 로고
    • Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen
    • Shibutani S, Ravindernath A, Suzuki N, Terashima I, Sugarman SM, et al. (2000) Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen. Carcinogenesis 21: 1461-1467.
    • (2000) Carcinogenesis , vol.21 , pp. 1461-1467
    • Shibutani, S.1    Ravindernath, A.2    Suzuki, N.3    Terashima, I.4    Sugarman, S.M.5
  • 46
    • 0033651439 scopus 로고    scopus 로고
    • MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells
    • Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, et al. (2000) MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Mol Endocrinol 14: 1882-1896.
    • (2000) Mol Endocrinol , vol.14 , pp. 1882-1896
    • Lee, H.1    Jiang, F.2    Wang, Q.3    Nicosia, S.V.4    Yang, J.5
  • 47
    • 33344461590 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells
    • Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, et al. (2006) The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol 20: 631-646.
    • (2006) Mol Endocrinol , vol.20 , pp. 631-646
    • Vivacqua, A.1    Bonofiglio, D.2    Recchia, A.G.3    Musti, A.M.4    Picard, D.5
  • 48
    • 32944461545 scopus 로고    scopus 로고
    • Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
    • Konecny GE, Pegram MD, Venkatesan N, Finn R, Yang G, et al. (2006) Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 66: 1630-1639.
    • (2006) Cancer Res , vol.66 , pp. 1630-1639
    • Konecny, G.E.1    Pegram, M.D.2    Venkatesan, N.3    Finn, R.4    Yang, G.5
  • 49
    • 11244257032 scopus 로고    scopus 로고
    • The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer
    • Chu I, Blackwell K, Chen S, Slingerland J, (2005) The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res 65: 18-25.
    • (2005) Cancer Res , vol.65 , pp. 18-25
    • Chu, I.1    Blackwell, K.2    Chen, S.3    Slingerland, J.4
  • 51
    • 32644442664 scopus 로고    scopus 로고
    • Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells
    • Acconcia F, Barnes CJ, Kumar R, (2006) Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells. Endocrinology 147: 1203-1212.
    • (2006) Endocrinology , vol.147 , pp. 1203-1212
    • Acconcia, F.1    Barnes, C.J.2    Kumar, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.