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Volumn 8, Issue 9, 2013, Pages

Long-Term Valproate Treatment Increases Brain Neuropeptide Y Expression and Decreases Seizure Expression in a Genetic Rat Model of Absence Epilepsy

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NEUROPEPTIDE Y; VALPROIC ACID;

EID: 84883643411     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073505     Document Type: Article
Times cited : (11)

References (67)
  • 1
    • 0036401554 scopus 로고    scopus 로고
    • Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience
    • Perucca E, (2002) Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 16: 695-714.
    • (2002) CNS Drugs , vol.16 , pp. 695-714
    • Perucca, E.1
  • 2
    • 33745792226 scopus 로고    scopus 로고
    • Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami
    • Brill J, Lee M, Zhao S, Fernald RD, Huguenard JR, (2006) Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J Neurosci 26: 6813-6822.
    • (2006) J Neurosci , vol.26 , pp. 6813-6822
    • Brill, J.1    Lee, M.2    Zhao, S.3    Fernald, R.D.4    Huguenard, J.R.5
  • 3
    • 0019495211 scopus 로고
    • Effect of sodium valproate on hypothalamic neurons in vivo and in vitro
    • Baldino F Jr, Geller HM, (1981) Effect of sodium valproate on hypothalamic neurons in vivo and in vitro. Brain Res 219: 231-237.
    • (1981) Brain Res , vol.219 , pp. 231-237
    • Baldino Jr., F.1    Geller, H.M.2
  • 4
    • 0020419213 scopus 로고
    • Acute effects of sodium valproate and gamma-vinyl GABA on regional amino acid metabolism in the rat brain: incorporation of 2-[14C]glucose into amino acids
    • Chapman AG, Riley K, Evans MC, Meldrum BS, (1982) Acute effects of sodium valproate and gamma-vinyl GABA on regional amino acid metabolism in the rat brain: incorporation of 2-[14C]glucose into amino acids. Neurochem Res 7: 1089-1105.
    • (1982) Neurochem Res , vol.7 , pp. 1089-1105
    • Chapman, A.G.1    Riley, K.2    Evans, M.C.3    Meldrum, B.S.4
  • 6
    • 1242351257 scopus 로고    scopus 로고
    • Valproate reduced excitatory postsynaptic currents in hippocampal CA1 pyramidal neurons
    • Martin ED, Pozo MA, (2004) Valproate reduced excitatory postsynaptic currents in hippocampal CA1 pyramidal neurons. Neuropharmacology 46: 555-561.
    • (2004) Neuropharmacology , vol.46 , pp. 555-561
    • Martin, E.D.1    Pozo, M.A.2
  • 7
    • 0022540479 scopus 로고
    • Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture
    • McLean MJ, Macdonald RL, (1986) Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 237: 1001-1011.
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 1001-1011
    • McLean, M.J.1    Macdonald, R.L.2
  • 8
    • 0002066179 scopus 로고    scopus 로고
    • Mechanisms of action of antiepileptic drugs
    • In: Wyllie E, editor, 2nd ed. Baltimore: Williams & Wilkins
    • Thomas A, Mathews G, Ferrendelli J (1996) Mechanisms of action of antiepileptic drugs. In: Wyllie E, editor. The Treatment of Epilepsy: Principles and Practice. 2nd ed. Baltimore: Williams & Wilkins. 700-711.
    • (1996) The Treatment of Epilepsy: Principles and Practice , pp. 700-711
    • Thomas, A.1    Mathews, G.2    Ferrendelli, J.3
  • 9
    • 0026741531 scopus 로고
    • Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. Antiepileptic actions
    • Altrup U, Gerlach G, Reith H, Said MN, Speckmann EJ, (1992) Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. Antiepileptic actions. Epilepsia 33: 743-752.
    • (1992) Epilepsia , vol.33 , pp. 743-752
    • Altrup, U.1    Gerlach, G.2    Reith, H.3    Said, M.N.4    Speckmann, E.J.5
  • 10
    • 0027728775 scopus 로고
    • Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat
    • Lucke A, Lehmenkuhler A, Altrup U, Nicholson C, Reith H, et al. (1993) Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat. Brain Res 631: 187-190.
    • (1993) Brain Res , vol.631 , pp. 187-190
    • Lucke, A.1    Lehmenkuhler, A.2    Altrup, U.3    Nicholson, C.4    Reith, H.5
  • 11
    • 0023264917 scopus 로고
    • Distributions of certain neuropeptides in the primate thalamus
    • Molinari M, Hendry SH, Jones EG, (1987) Distributions of certain neuropeptides in the primate thalamus. Brain Res 426: 270-289.
    • (1987) Brain Res , vol.426 , pp. 270-289
    • Molinari, M.1    Hendry, S.H.2    Jones, E.G.3
  • 12
    • 0024845552 scopus 로고
    • Neuronal localisation of neuropeptide Y gene expression in rat brain
    • Morris BJ, (1989) Neuronal localisation of neuropeptide Y gene expression in rat brain. J Comp Neurol 290: 358-368.
    • (1989) J Comp Neurol , vol.290 , pp. 358-368
    • Morris, B.J.1
  • 14
    • 4444339761 scopus 로고    scopus 로고
    • Neuropeptide Y and epilepsy: recent progress, prospects and controversies
    • Baraban SC, (2004) Neuropeptide Y and epilepsy: recent progress, prospects and controversies. Neuropeptides 38: 261-265.
    • (2004) Neuropeptides , vol.38 , pp. 261-265
    • Baraban, S.C.1
  • 15
    • 0033457358 scopus 로고    scopus 로고
    • Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition
    • Redrobe JP, Dumont Y, St-Pierre JA, Quirion R, (1999) Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res 848: 153-166.
    • (1999) Brain Res , vol.848 , pp. 153-166
    • Redrobe, J.P.1    Dumont, Y.2    St-Pierre, J.A.3    Quirion, R.4
  • 17
    • 33846578348 scopus 로고    scopus 로고
    • NPY signaling through Y1 receptors modulates thalamic oscillations
    • Brill J, Kwakye G, Huguenard JR, (2007) NPY signaling through Y1 receptors modulates thalamic oscillations. Peptides 28: 250-256.
    • (2007) Peptides , vol.28 , pp. 250-256
    • Brill, J.1    Kwakye, G.2    Huguenard, J.R.3
  • 18
    • 33847217308 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y2 receptors
    • Morris MJ, Gannan E, Stroud LM, Beck-Sickinger AG, O'Brien TJ, (2007) Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y2 receptors. Eur J Neurosci 25: 1136-1143.
    • (2007) Eur J Neurosci , vol.25 , pp. 1136-1143
    • Morris, M.J.1    Gannan, E.2    Stroud, L.M.3    Beck-Sickinger, A.G.4    O'Brien, T.J.5
  • 19
    • 0035425623 scopus 로고    scopus 로고
    • Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy
    • Furtinger S, Pirker S, Czech T, Baumgartner C, Ransmayr G, et al. (2001) Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy. J Neurosci 21: 5804-5812.
    • (2001) J Neurosci , vol.21 , pp. 5804-5812
    • Furtinger, S.1    Pirker, S.2    Czech, T.3    Baumgartner, C.4    Ransmayr, G.5
  • 20
    • 0025938310 scopus 로고
    • Increased preproneuropeptide Y mRNA in the rat hippocampus during the development of hippocampal kindling: comparison with the expression of preprosomatostatin mRNA
    • Bendotti C, Vezzani A, Serafini R, Servadio A, Rivolta R, et al. (1991) Increased preproneuropeptide Y mRNA in the rat hippocampus during the development of hippocampal kindling: comparison with the expression of preprosomatostatin mRNA. Neurosci Lett 132: 175-178.
    • (1991) Neurosci Lett , vol.132 , pp. 175-178
    • Bendotti, C.1    Vezzani, A.2    Serafini, R.3    Servadio, A.4    Rivolta, R.5
  • 21
    • 0028839544 scopus 로고
    • Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy
    • Schwarzer C, Williamson JM, Lothman EW, Vezzani A, Sperk G, (1995) Somatostatin, neuropeptide Y, neurokinin B and cholecystokinin immunoreactivity in two chronic models of temporal lobe epilepsy. Neuroscience 69: 831-845.
    • (1995) Neuroscience , vol.69 , pp. 831-845
    • Schwarzer, C.1    Williamson, J.M.2    Lothman, E.W.3    Vezzani, A.4    Sperk, G.5
  • 22
    • 0025326538 scopus 로고
    • Seizures, neuropeptide regulation, and mRNA expression in the hippocampus
    • Gall C, Lauterborn J, Isackson P, White J, (1990) Seizures, neuropeptide regulation, and mRNA expression in the hippocampus. Prog Brain Res 83: 371-390.
    • (1990) Prog Brain Res , vol.83 , pp. 371-390
    • Gall, C.1    Lauterborn, J.2    Isackson, P.3    White, J.4
  • 23
    • 0024330051 scopus 로고
    • Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats
    • Pitkanen A, Beal MF, Sirvio J, Swartz KJ, Mannisto PT, et al. (1989) Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides 14: 197-207.
    • (1989) Neuropeptides , vol.14 , pp. 197-207
    • Pitkanen, A.1    Beal, M.F.2    Sirvio, J.3    Swartz, K.J.4    Mannisto, P.T.5
  • 24
    • 0026786520 scopus 로고
    • Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat
    • Sperk G, Marksteiner J, Gruber B, Bellmann R, Mahata M, et al. (1992) Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience 50: 831-846.
    • (1992) Neuroscience , vol.50 , pp. 831-846
    • Sperk, G.1    Marksteiner, J.2    Gruber, B.3    Bellmann, R.4    Mahata, M.5
  • 25
    • 0029050681 scopus 로고
    • Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain
    • Zachrisson O, Mathe AA, Stenfors C, Lindefors N, (1995) Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain. Brain Res Mol Brain Res 31: 71-85.
    • (1995) Brain Res Mol Brain Res , vol.31 , pp. 71-85
    • Zachrisson, O.1    Mathe, A.A.2    Stenfors, C.3    Lindefors, N.4
  • 26
    • 0028822628 scopus 로고
    • Inhibitory effect of neuropeptide y on epileptiform activity in the frontal cortex and hippocampus in vitro
    • Bijak M, (1995) Inhibitory effect of neuropeptide y on epileptiform activity in the frontal cortex and hippocampus in vitro. Pol J Pharmacol 47: 461-463.
    • (1995) Pol J Pharmacol , vol.47 , pp. 461-463
    • Bijak, M.1
  • 27
    • 0036340642 scopus 로고    scopus 로고
    • Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors
    • Baraban SC, (2002) Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors. Epilepsia 43Suppl 5: 9-13.
    • (2002) Epilepsia , vol.43 , pp. 9-13
    • Baraban, S.C.1
  • 28
    • 0030796367 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro
    • Klapstein GJ, Colmers WF, (1997) Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J Neurophysiol 78: 1651-1661.
    • (1997) J Neurophysiol , vol.78 , pp. 1651-1661
    • Klapstein, G.J.1    Colmers, W.F.2
  • 29
    • 84857658207 scopus 로고    scopus 로고
    • Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model
    • van Raay L, Jovanovska V, Morris MJ, O'Brien TJ, (2012) Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model. Epilepsia 53: 477-484.
    • (2012) Epilepsia , vol.53 , pp. 477-484
    • van Raay, L.1    Jovanovska, V.2    Morris, M.J.3    O'Brien, T.J.4
  • 30
    • 0030752410 scopus 로고    scopus 로고
    • Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors
    • Woldbye DP, Larsen PJ, Mikkelsen JD, Klemp K, Madsen TM, et al. (1997) Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat Med 3: 761-764.
    • (1997) Nat Med , vol.3 , pp. 761-764
    • Woldbye, D.P.1    Larsen, P.J.2    Mikkelsen, J.D.3    Klemp, K.4    Madsen, T.M.5
  • 32
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson JC, Clegg KE, Palmiter RD, (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381: 415-421.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 34
    • 0037066064 scopus 로고    scopus 로고
    • Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y
    • Vezzani A, Michalkiewicz M, Michalkiewicz T, Moneta D, Ravizza T, et al. (2002) Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience. 110: 237-243.
    • (2002) Neuroscience , vol.110 , pp. 237-243
    • Vezzani, A.1    Michalkiewicz, M.2    Michalkiewicz, T.3    Moneta, D.4    Ravizza, T.5
  • 35
    • 0026611823 scopus 로고
    • Genetic absence epilepsy in rats from Strasbourg-a review
    • Marescaux C, Vergnes M, Depaulis A (1992) Genetic absence epilepsy in rats from Strasbourg-a review. J Neural Transm Suppl 35: 37-69.
    • (1992) J Neural Transm Suppl , vol.35 , pp. 37-69
    • Marescaux, C.1    Vergnes, M.2    Depaulis, A.3
  • 38
    • 78650801288 scopus 로고    scopus 로고
    • Fluctuating and constant valproate administration gives equivalent seizure control in rats with genetic and acquired epilepsy
    • Dedeurwaerdere S, van Raay L, Morris MJ, Reed RC, Hogan RE, et al. (2011) Fluctuating and constant valproate administration gives equivalent seizure control in rats with genetic and acquired epilepsy. Seizure 20: 72-79.
    • (2011) Seizure , vol.20 , pp. 72-79
    • Dedeurwaerdere, S.1    van Raay, L.2    Morris, M.J.3    Reed, R.C.4    Hogan, R.E.5
  • 39
    • 63049129766 scopus 로고    scopus 로고
    • A novel system allowing long-term simultaneous video-electroencephalography recording, drug infusion and blood sampling in rats
    • van Raay L, Morris MJ, Reed RC, O'Brien TJ, Dedeurwaerdere S, (2009) A novel system allowing long-term simultaneous video-electroencephalography recording, drug infusion and blood sampling in rats. J Neurosci Methods 179: 184-190.
    • (2009) J Neurosci Methods , vol.179 , pp. 184-190
    • van Raay, L.1    Morris, M.J.2    Reed, R.C.3    O'Brien, T.J.4    Dedeurwaerdere, S.5
  • 40
    • 0035695761 scopus 로고    scopus 로고
    • Nonstationary disposition of valproic acid during prolonged intravenous infusion: contributions of unbound clearance and protein binding
    • Arens TL, Pollack GM, (2001) Nonstationary disposition of valproic acid during prolonged intravenous infusion: contributions of unbound clearance and protein binding. Biopharm Drug Dispos 22: 243-249.
    • (2001) Biopharm Drug Dispos , vol.22 , pp. 243-249
    • Arens, T.L.1    Pollack, G.M.2
  • 41
    • 47149092036 scopus 로고    scopus 로고
    • Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin
    • Powell KL, Kyi M, Reid CA, Paradiso L, D'Abaco GM, et al. (2008) Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin. Neurobiol Dis 31: 261-265.
    • (2008) Neurobiol Dis , vol.31 , pp. 261-265
    • Powell, K.L.1    Kyi, M.2    Reid, C.A.3    Paradiso, L.4    D'Abaco, G.M.5
  • 42
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 43
    • 0018414452 scopus 로고
    • The delayed effect of sodium valproate on the photoconvulsive response in man
    • Rowan AJ, Binnie CD, Warfield CA, Meinardi H, Meijer JW, (1979) The delayed effect of sodium valproate on the photoconvulsive response in man. Epilepsia 20: 61-68.
    • (1979) Epilepsia , vol.20 , pp. 61-68
    • Rowan, A.J.1    Binnie, C.D.2    Warfield, C.A.3    Meinardi, H.4    Meijer, J.W.5
  • 44
    • 0037742375 scopus 로고    scopus 로고
    • Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    • Loscher W, (1999) Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Prog Neurobiol 58: 31-59.
    • (1999) Prog Neurobiol , vol.58 , pp. 31-59
    • Loscher, W.1
  • 45
    • 0018621544 scopus 로고
    • Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo
    • Iadarola MJ, Gale K, (1979) Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo. Eur J Pharmacol 59: 125-129.
    • (1979) Eur J Pharmacol , vol.59 , pp. 125-129
    • Iadarola, M.J.1    Gale, K.2
  • 46
    • 0021944134 scopus 로고
    • In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities
    • Loscher W, Vetter M, (1985) In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities. Biochem Pharmacol 34: 1747-1756.
    • (1985) Biochem Pharmacol , vol.34 , pp. 1747-1756
    • Loscher, W.1    Vetter, M.2
  • 47
    • 0021638046 scopus 로고
    • Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children
    • Loscher W, Siemes H, (1984) Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children. Lancet 2: 225.
    • (1984) Lancet , vol.2 , pp. 225
    • Loscher, W.1    Siemes, H.2
  • 48
    • 0021879046 scopus 로고
    • Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment
    • Loscher W, Siemes H, (1985) Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment. Epilepsia 26: 314-319.
    • (1985) Epilepsia , vol.26 , pp. 314-319
    • Loscher, W.1    Siemes, H.2
  • 49
    • 0019125373 scopus 로고
    • Increase of human plasma GABA by sodium valproate
    • Loscher W, Schmidt D, (1980) Increase of human plasma GABA by sodium valproate. Epilepsia 21: 611-615.
    • (1980) Epilepsia , vol.21 , pp. 611-615
    • Loscher, W.1    Schmidt, D.2
  • 50
    • 0019885838 scopus 로고
    • Plasma GABA levels in neurological patients under treatment with valproic acid
    • Loscher W, Schmidt D, (1981) Plasma GABA levels in neurological patients under treatment with valproic acid. Life Sci 28: 283-288.
    • (1981) Life Sci , vol.28 , pp. 283-288
    • Loscher, W.1    Schmidt, D.2
  • 51
    • 0142213164 scopus 로고    scopus 로고
    • Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus
    • Sun QQ, Baraban SC, Prince DA, Huguenard JR, (2003) Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci 23: 9639-9649.
    • (2003) J Neurosci , vol.23 , pp. 9639-9649
    • Sun, Q.Q.1    Baraban, S.C.2    Prince, D.A.3    Huguenard, J.R.4
  • 52
    • 20144365152 scopus 로고    scopus 로고
    • Sleep, epilepsy and thalamic reticular inhibitory neurons
    • Steriade M, (2005) Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends Neurosci 28: 317-324.
    • (2005) Trends Neurosci , vol.28 , pp. 317-324
    • Steriade, M.1
  • 53
    • 34147199586 scopus 로고    scopus 로고
    • Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation
    • Sinn DI, Kim SJ, Chu K, Jung KH, Lee ST, et al. (2007) Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation. Neurobiol Dis 26: 464-472.
    • (2007) Neurobiol Dis , vol.26 , pp. 464-472
    • Sinn, D.I.1    Kim, S.J.2    Chu, K.3    Jung, K.H.4    Lee, S.T.5
  • 54
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, et al. (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734-36741.
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5
  • 55
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, et al. (2001) Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20: 6969-6978.
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3    Kramer, O.H.4    Schimpf, A.5
  • 56
    • 0037925520 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
    • Kramer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, et al. (2003) The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 22: 3411-3420.
    • (2003) EMBO J , vol.22 , pp. 3411-3420
    • Kramer, O.H.1    Zhu, P.2    Ostendorff, H.P.3    Golebiewski, M.4    Tiefenbach, J.5
  • 57
    • 34247850849 scopus 로고    scopus 로고
    • Regulation of the HIF-1alpha stability by histone deacetylases
    • Kim SH, Jeong JW, Park JA, Lee JW, Seo JH, et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep 17: 647-651.
    • (2007) Oncol Rep , vol.17 , pp. 647-651
    • Kim, S.H.1    Jeong, J.W.2    Park, J.A.3    Lee, J.W.4    Seo, J.H.5
  • 58
    • 28844473025 scopus 로고    scopus 로고
    • Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells
    • Castro LM, Gallant M, Niles LP, (2005) Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J Neurochem 95: 1227-1236.
    • (2005) J Neurochem , vol.95 , pp. 1227-1236
    • Castro, L.M.1    Gallant, M.2    Niles, L.P.3
  • 59
    • 34247224239 scopus 로고    scopus 로고
    • Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
    • Bredy TW, Wu H, Crego C, Zellhoefer J, Sun YE, et al. (2007) Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem 14: 268-276.
    • (2007) Learn Mem , vol.14 , pp. 268-276
    • Bredy, T.W.1    Wu, H.2    Crego, C.3    Zellhoefer, J.4    Sun, Y.E.5
  • 60
    • 55549129648 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
    • Wu X, Chen PS, Dallas S, Wilson B, Block ML, et al. (2008) Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. Int J Neuropsychopharmacol 11: 1123-1134.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 1123-1134
    • Wu, X.1    Chen, P.S.2    Dallas, S.3    Wilson, B.4    Block, M.L.5
  • 61
    • 0033816614 scopus 로고    scopus 로고
    • Endogenous control of hippocampal epileptogenesis: a molecular cascade involving brain-derived neurotrophic factor and neuropeptide Y
    • Reibel S, Larmet Y, Carnahan J, Marescaux C, Depaulis A, (2000) Endogenous control of hippocampal epileptogenesis: a molecular cascade involving brain-derived neurotrophic factor and neuropeptide Y. Epilepsia. 41Suppl 6: S127-133.
    • (2000) Epilepsia , vol.41
    • Reibel, S.1    Larmet, Y.2    Carnahan, J.3    Marescaux, C.4    Depaulis, A.5
  • 62
    • 0034050846 scopus 로고    scopus 로고
    • Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting
    • Reibel S, Vivien-Roels B, Le BT, Larmet Y, Carnahan J, et al. (2000) Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. Eur J Neurosci 12: 595-605.
    • (2000) Eur J Neurosci , vol.12 , pp. 595-605
    • Reibel, S.1    Vivien-Roels, B.2    Le, B.T.3    Larmet, Y.4    Carnahan, J.5
  • 63
    • 34249780805 scopus 로고    scopus 로고
    • Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions
    • Hamed SA, (2007) Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions. Epilepsy Res 75: 1-9.
    • (2007) Epilepsy Res , vol.75 , pp. 1-9
    • Hamed, S.A.1
  • 64
    • 70449505386 scopus 로고    scopus 로고
    • Metabolic alterations during valproic acid treatment: a prospective study
    • Abaci A, Saygi M, Yis U, Demir K, Dirik E, et al. (2009) Metabolic alterations during valproic acid treatment: a prospective study. Pediatr Neurol 41: 435-439.
    • (2009) Pediatr Neurol , vol.41 , pp. 435-439
    • Abaci, A.1    Saygi, M.2    Yis, U.3    Demir, K.4    Dirik, E.5
  • 65
    • 69049121428 scopus 로고    scopus 로고
    • Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial
    • Martin CK, Han H, Anton SD, Greenway FL, Smith SR, (2009) Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial. J Psychopharmacol 23: 814-825.
    • (2009) J Psychopharmacol , vol.23 , pp. 814-825
    • Martin, C.K.1    Han, H.2    Anton, S.D.3    Greenway, F.L.4    Smith, S.R.5
  • 66
    • 79955635264 scopus 로고    scopus 로고
    • Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
    • Chao PT, Yang L, Aja S, Moran TH, Bi S, (2011) Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab 13: 573-583.
    • (2011) Cell Metab , vol.13 , pp. 573-583
    • Chao, P.T.1    Yang, L.2    Aja, S.3    Moran, T.H.4    Bi, S.5
  • 67
    • 58149377292 scopus 로고    scopus 로고
    • Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance
    • Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, et al. (2009) Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci 29: 179-190.
    • (2009) J Neurosci , vol.29 , pp. 179-190
    • Yang, L.1    Scott, K.A.2    Hyun, J.3    Tamashiro, K.L.4    Tray, N.5


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