Nonstationary disposition of valproic acid during prolonged intravenous infusion: Contributions of unbound clearance and protein binding

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 6, 2001, Pages 243-249

  Arens, Tori L ^a,b   Pollack, Gary M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b EISAI INC   (United States)

Author keywords

Diurnal variation; Pharmacokinetics; Protein binding; Valproate

Indexed keywords

ANTICONVULSIVE AGENT; VALPROIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CIRCADIAN RHYTHM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG INFUSION; DRUG PROTEIN BINDING; GAS CHROMATOGRAPHY; MALE; MICRODIALYSIS; NONHUMAN; OSCILLATION; RAT; STEADY STATE; VASCULAR ACCESS;

ALGORITHMS; ANIMALS; ANTICONVULSANTS; CALIBRATION; CHROMATOGRAPHY, GAS; CIRCADIAN RHYTHM; INFUSIONS, INTRAVENOUS; MALE; MICRODIALYSIS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VALPROIC ACID;

EID: 0035695761     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.259     Document Type: Article

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