Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool

Journal of Inorganic Biochemistry

Volumn 129, Issue , 2013, Pages 43-51

  Walcourt, Asikiya ^a   Kurantsin Mills, Joseph ^a,b   Kwagyan, John ^c   Adenuga, Babafemi B ^a   Kalinowski, Danuta S ^d   Lovejoy, David B ^d   Lane, Darius J R ^d   Richardson, Des R ^d  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c HOWARD UNIVERSITY HOSPITAL   (United States)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Aroylhydrazone; Erythrocytes; Iron chelator; Plasmodium falciparum; Thiosemicarbazone

Indexed keywords

2 HYDROXY 1 NAPHTHYLALDEHYDE 4 METHYL 3 THIOSEMICARBAZONE; 2 HYDROXY 1 NAPHTHYLALDEHYDE 4 PHENYL 3 THIOSEMICARBAZONE; 2 HYDROXY 1 NAPHTHYLALDEHYDE ISONICOTINOYL HYDRAZONE; HYDRAZONE DERIVATIVE; IRON; IRON CHELATING AGENT; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTIPLASMODIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE MEMBRANE; ERYTHROCYTE SHAPE; HEMOLYSIS; HUMAN; HUMAN CELL; IC 50; IRON CHELATION; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; SCHIZONT; TROPHOZOITE;

ANIMALIA; PLASMODIUM FALCIPARUM;

AROYLHYDRAZONE; ERYTHROCYTES; IRON CHELATOR; PLASMODIUM FALCIPARUM; THIOSEMICARBAZONE;

ANTIMALARIALS; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMANS; HYDRAZONES; IRON CHELATING AGENTS; PLASMODIUM FALCIPARUM; SEMICARBAZIDES;

EID: 84883612584     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2013.08.007     Document Type: Article

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