DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function

Gynecological Endocrinology

Volumn 29, Issue 10, 2013, Pages 940-943

  Fusi, Francesco M ^a,b   Ferrario, Marina ^a   Bosisio, Chiara ^a   Arnoldi, Mariangela ^a   Zanga, Laura ^a  

^a PAPA GIOVANNI XXIII HOSPITAL   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Androgens; Dehydroepiandrosterone; in vitro fertilization; Ovarian reserve; Poor responders; Pregnancy rate

Indexed keywords

GONADOTROPIN; PRASTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; TRIPTORELIN;

ADULT; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFICACY; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; OVARY FUNCTION; PARTHENOGENESIS; PREGNANCY RATE; PRIORITY JOURNAL; PROGNOSIS; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; COHORT STUDIES; DEHYDROEPIANDROSTERONE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; MALE; PREGNANCY; PREGNANCY RATE; PRIMARY OVARIAN INSUFFICIENCY; TIME-TO-PREGNANCY;

EID: 84883566645     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2013.819087     Document Type: Article

References (28)

1. Gleicher N, Weghofer A, Barad DH. Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol 2011;9:23.
2. Weghofer A, Kim A, Barad DH, Gleicher N. The impact of androgen metabolism and FMR1 genotypes on pregnancy potential in women with dehydroepiandrosterone (DHEA) supplementation. Hum Reprod 2012;27:3287-93.
3. Hyman JH, Margalioth EJ, Rabinowitz R, et al. DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism. Eur J Obstet Gynecol Reprod Biol 2013;168:49-53.
4. Vollenhoven B, Osianlis T, Catt J. Is there an ideal stimulation regimen for IVF for poor responders and does it change with age? J Assist Reprod Genet 2008;25:523-9.
5. Ulug U, Ben-Shlomo I, Turan E, et al. Conception rates following assisted reproduction in poor responder patients: a retrospective study in 300 consecutive cycles. Reprod Biomed Online 2003;6: 439-43.
6. Mohamed KA, Davies WA, Allsopp J, Lashen H. Agonist 'flare-up' versus antagonist in the management of poor responders undergoing in vitro fertilization treatment. Fertil Steril 2005;83:331-5.
7. Frattarelli JL, Hill MJ, McWilliams GD, et al. A luteal estradiol protocol for expected poor-responders improves embryo number and quality. Fertil Steril 2008;89:1118-22.
8. Gleicher N, Weghofer A, Barad DH. The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment? Reprod Biol Endocrinol 2011;9:116.
9. Casson PR, Lindsay MS, Pisarska MD, et al. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum Reprod 2002;15: 2129-32.
10. Burger HG. Androgen production in women. Fertil Steril 2002;77: S3-5.
11. Mamas L, Mamas E. Premature ovarian failure and dehydroepiandrosterone. Fertil Steril 2009;91:644-6.
12. Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007;24:629-34.
13. Gleicher N, Barad DH. Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reprod Biol Endocrinol 2011;9:67.
14. Wiser A, Gonen O, Ghetler Y, et al. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod 2010;25:2496-500.
15. Sönmezer M, Ozmen B, Cil AP, et al. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online 2009;19:508-13.
16. Gleicher N, Weghofer A, Barad DH. Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation. Reprod Biomed Online 2010;21:360-5.
17. Weissman A, Horowitz E, Ravhon A, et al. Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels. Gynecol Endocrinol 2011;27:1014-7.
18. Artini PG, Simi G, Ruggiero M, et al. DHEA supplementation improves follicular microenviroment in poor responder patients. Gynecol Endocrinol 2012;28:669-73.
19. Gleicher N, Weghofer A, Barad DH. Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS). Reprod Biol Endocrinol 2010;8:140.
20. Sunkara SK, Coomarasamy A, Arlt W, et al. Should androgen supplementation be used for poor ovarian response in IVF? Hum Reprod 2012;27:637-40.
21. Hillier SG, Whitelaw PF, Smyth CD. Follicular estrogen synthesis: the '2-cell, two-gonadotrophin' model revisited. Mol Cell Endocrinol 1994;100:51-4.
22. Haning Jr RV, Hackett RJ, Flood CA, et al. Plasma dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins. J Clin Endocrinol Metab 1993;76:1301-7.
23. Casson PR, Santoro N, Elkind-Hirsch K, et al. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial. Fertil Steril 1998;70:107-10.
24. Bahceci M, Ulug U, Turan E, Akman MA. Comparisons of follicular levels of sex steroids, gonadotropins and insulin like growth factor-1 (IGF-1) and epidermal growth factor (EGF) in poor responder and normoresponder patients undergoing ovarian stimulation with GnRH antagonist. Eur J Obstet Gynecol Reprod Biol 2007;130:93-8.
25. Howles CM, Loumaye E, Germond M, et al. Does growth hormonereleasing factor assist follicular development in poor responder patients undergoing ovarian stimulation for in vitro fertilization? Hum Reprod 1999;14:1939-43.
26. Kobayashi N, Orisaka M, Cao M, et al. Growth differentiation factor-9 mediates follicle-stimulating hormone-thyroid hormone interaction in the regulation of rat preantral follicular development. Endocrinology 2009;150:5566-74.
27. Hickey TE, Marrocco DL, Amato F, et al. Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells. Biol Reprod 2005;73: 825-32.
28. Gleicher N, Kim A, Weghofer A, et al. Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR). J Assist Reprod Genet 2013;30: 49-62.