Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels

Gynecological Endocrinology

Volumn 27, Issue 12, 2011, Pages 1014-1017

  Weissman, Ariel ^a,b   Horowitz, Eran ^a,b   Ravhon, Amir ^a,b   Golan, Abraham ^a,b   Levran, David ^a,b  

^a WOLFSON MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Dehydroepiandrosterone; DHEA; diminished ovarian reserve; IVF; progesterone

Indexed keywords

CHORIONIC GONADOTROPIN; PRASTERONE; PROGESTERONE;

ADULT; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FOLLICULAR PHASE; HUMAN; OOCYTE; OVARIAN RESERVE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL;

ADULT; CELL COUNT; COHORT STUDIES; DEHYDROEPIANDROSTERONE; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; FERTILIZATION IN VITRO; FOLLICULAR PHASE; HUMANS; INFERTILITY, FEMALE; OVARY; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROGESTERONE; RETROSPECTIVE STUDIES; UP-REGULATION;

EID: 80955135440     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.569611     Document Type: Article

References (26)

1. Pellicer A, Lightman A, Diamond MP, Russell JB, DeCherney AH. Outcome of in vitro fertilization in women with low response to ovarian stimulation. Fertil Steril 1987;47: 812-815.
2. Van Rysselberge M, Puissant F, Barlow P, Lejeune B, Delvigne A, Leroy F. Fertility prognosis in IVF treatment of patients with cancelled cycles. Hum Reprod 1989;4:663-666.
3. Jenkins JM, Davies DW, Devonport H, Anthony FW, Gadd SC, Watson RH, Masson GM. Comparison of 'poor' responders with 'good' responders using a standard buserelin/ human menopausal gonadotrophin regime for in-vitro fertilization. Hum Reprod 1991;6:918-921.
4. Stadtmauer L, Ditkoff EC, Session D, Kelly A. High dosages of gonadotropins are associated with poor pregnancy outcomes after in vitro fertilization-embryo transfer. Fertil Steril 1994;61:1058-1064.
5. Manzi DL, Thornton KL, Scott LB, Nulsen JC. The value of increasing the dose of human menopausal gonadotropins in women who initially demonstrate a poor response. Fertil Steril 1994;62:251-256.
6. Land JA, Yarmolinskaya MI, Dumoulin JC, Evers JL. Highdose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertil Steril 1996;65:961-965.
7. Weissman A, Howles CM. Treatment strategies in assisted reproduction for the low responder patient. In: Gardner DK, Weissman A, Howles CM, Shoham Z, editors. Assisted reproductive techniques: laboratory and clinical perspectives. 3rd ed. London, UK: Informa Healthcare; 2009. pp 577-615.
8. Casson PR, Lindsay MS, Pisarska MD, Carson SA, Buster JE. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum Reprod 2000;15:2129-2132.
9. Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007;24: 629-634.
10. Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 2006;21:2845-2849.
11. Wiser A, Gonen O, Ghetler Y, Shavit T, Berkovitz A, Shulman A. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod 2010;25:2496-2500.
12. Weissman A, Farhi J, Royburt M, Nahum H, Glezerman M, Levran D. Prospective evaluation of two stimulation protocols for low responders who were undergoing in vitro fertilizationembryo transfer. Fertil Steril 2003;79:886-892.
13. Kolibianakis EM, Zikopoulos K, Smitz J, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists. Hum Reprod 2004;19:1525-1529.
14. Barad DH, Gleicher N. Increased oocyte production after treatment with dehydroepiandrosterone. Fertil Steril 2005;84: 756.
15. Gleicher N, Ryan E, Weghofer A, Blanco-Mejia S, Barad DH. Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. Reprod Biol Endocrinol 2009;7:108.
16. Gleicher N, Weghofer A, Barad DH. Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation. Reprod Biomed Online 2010;21:360-365.
17. Genazzani AR, Pluchino N, Begliuomini S, Stomati M, Bernardi F, Pieri M, Casarosa E, Palumbo M, Genazzani AD, Luisi M. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol 2006;22:627-635.
18. Pluchino N, Ninni F, Stomati M, Freschi L, Casarosa E, Valentino V, Luisi S, Genazzani AD, Poti E, Genazzani AR. One-year thERαpy with 10 mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu. Maturitas 2008;59:293-303.
19. Genazzani AR, Inglese S, Lombardi I, Pieri M, Bernardi F, Genazzani AD, Rovati L, Luisi M. Long-term lowdose dehydroepiandrosterone replacement thpy in aging males with partial androgen deficiency. Aging Male 2004;7: 133-143.
20. Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005.
21. Venetis CA, Kolibianakis EM, Papanikolaou E, Bontis J, Devroey P, Tarlatzis BC. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update 2007;13:343-355.
22. Genazzani AD, Stomati M, Bernardi F, Pieri M, Rovati L, Genazzani AR. Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women odulates endocrine parameters and synthesis of neuroactive steroids. Fertil Steril 2003;80:495-501.
23. Fleming R, Jenkins J. The source and implications of progesterone rise during the follicular phase of assisted reproduction cycles. Reprod Biomed Online 2010;21: 446-449.
24. Ezra Y, Simon A, Sherman Y, Benshushan A, Younis JS, Laufer N. The effect of progesterone administration in the follicular phase of an artificial cycle on endometrial morphology: a model of premature luteinization. Fertil Steril 1994;62: 108-112.
25. Fanchin R, de Ziegler D, Taieb J, Hazout A, Frydman R. Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer. Fertil Steril 1993;59:1090-1094.
26. Hsiung CH, Karow WG, Gentry WC, Pope AK, Lee TT. Tripling of serum progesterone (P4) and embryonic morphological features in conception and nonconception cycles, after human in vitro fertilization. J In Vitro Fert Embryo Transf 1988;5:161-166.