Administration of telmisartan reduced systolic blood pressure and oxidative stress probably through the activation of PI3K/Akt/eNOS pathway and NO release in spontaneously hypertensive rats

Physiological Research

Volumn 62, Issue 4, 2013, Pages 351-359

  Xu, L ^a   Liu, Y ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tianjin Chest Hospital   (China)

Author keywords

Angiotensin; Hypertension; NO; Oxidative stress; Telmisartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NITRIC OXIDE; NOS3 PROTEIN, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TELMISARTAN;

ANIMAL; ARTICLE; BLOOD PRESSURE; CELL CULTURE; DISEASE MODEL; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HYPERTENSION; MALE; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; TIME; WISTAR KYOTO RAT;

AMP-ACTIVATED PROTEIN KINASES; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; BENZOATES; BLOOD PRESSURE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HYPERTENSION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84883550581     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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