Enhancement of vasorelaxation in hypertension following high-intensity Exercise

Chinese Journal of Physiology

Volumn 54, Issue 2, 2011, Pages 87-95

  Yang, Ai Lun ^a   Lo, Chia Wen ^a   Lee, Jen Ting ^b   Su, Chia Ting ^c  

^a UNIVERSITY OF TAIPEI   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Aorta; Exercise; Nitric oxide; Superoxide; Vasorelaxation

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN C; SUPEROXIDE DISMUTASE; ANTIDIABETIC AGENT; NITRIC OXIDE DONOR; NOS3 PROTEIN, RAT; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME SYNTHESIS; EXERCISE INTENSITY; HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; TREADMILL EXERCISE; VASODILATATION; WESTERN BLOTTING; WISTAR KYOTO RAT; ANIMAL; AORTA; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HYPERTENSION; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SUPEROXIDES; VASODILATION;

EID: 79551525720     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: 10.4077/CJP.2011.AMM011     Document Type: Article

References (41)

1. Amundsen, B.H., Rognmo, O., Hatlen-Rebhan, G. and Slordahl, S.A. High-intensity aerobic exercise improves diastolic function in coronary artery disease. Scand. Cardiovasc. J. 42: 110-117, 2008.
2. Brook, R.D. and Julius, S. Autonomic imbalance, hypertension, and cardiovascular risk. Am. J. Hypertens. 13 (6 Pt 2): 112S-122S, 2000.
3. Ceriello, A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 31: S181-S184, 2008.
4. Chen, C., Korshunov, V.A., Massett, M.P., Yan, C. and Berk, B.C. Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways. J. Vasc. Res. 44: 504-512, 2007.
5. Chen, H.I., Chiang, I.P. and Jen, C.J. Exercise training increases acetylcholine-stimulated endothelium-derived nitric oxide release in spontaneously hypertensive rats. J. Biomed. Sci. 3: 454-460, 1996.
6. Cheng, L., Yang, C., Hsu, L., Lin, M.T., Jen, C.J. and Chen, H.I. Acute exercise enhances receptor-mediated endothelium-dependent vasodilation by receptor upregulation. J. Biomed. Sci. 6: 22- 27, 1999.
7. Cornelissen, V.A. and Fagard, R.H. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension 46: 667-675, 2005.
8. Esler, M. The sympathetic system and hypertension. Am. J. Hypertens. 13: 99S-105S, 2000.
9. Fagard, R.H. Exercise characteristics and the blood pressure response to dynamic physical training. Med. Sci. Sports Exerc. 33: S484-S492, 2001.
10. Gormley, S.E., Swain, D.P., High, R., Spina, R.J., Dowling, E.A., Kotipalli, U.S. and Gandrakota, R. Effect of intensity of aerobic training on VO2max. Med. Sci. Sports Exerc. 40: 1336-1343, 2008.
11. Graham, D.A. and Rush, J.W. Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J. Appl. Physiol. 96: 2088-2096, 2004.
12. Hamilton, C.A., Brosnan, M.J., McIntyre, M., Graham, D. and Dominiczak, A.F. Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37: 529- 534, 2001.
13. Hasdai, D., Rizza, R.A., Holmes, D.R., Jr., Richardson, D.M., Cohen, P. and Lerman, A. Insulin and insulin-like growth factor-I cause coronary vasorelaxation in vitro. Hypertension 32: 228-234, 1998.
14. Kerr, S., Brosnan, M.J., McIntyre, M., Reid, J.L., Dominiczak, A.F. and Hamilton, C.A. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 33: 1353-1358, 1999.
15. Kobayashi, T. and Kamata, K. Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats. Am. J. Physiol. Heart Circ. Physiol. 283: H1761-H1768, 2002.
16. Maiorana, A., O'Driscoll, G., Taylor, R. and Green, D. Exercise and the nitric oxide vasodilator system. Sports Med. 33: 1013-1035, 2003.
17. McCallum, R.W., Hamilton, C.A., Graham, D., Jardine, E., Connell, J.M. and Dominiczak, A.F. Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. J. Hypertens. 23: 351-358, 2005.
18. Oberman, A., Fletcher, G.F., Lee, J., Nanda, N., Fletcher, B.J., Jensen, B. and Caldwell, E.S. Efficacy of high-intensity exercise training on left ventricular ejection fraction in men with coronary artery disease (the Training Level Comparison Study). Am. J. Cardiol. 76: 643-647, 1995.
19. O'Donovan, G., Owen, A., Bird, S.R., Kearney, E.M., Nevill, A.M., Jones, D.W. and Woolf-May, K. Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost. J. Appl. Physiol. 98: 1619-1625, 2005.
20. Orescanin, Z.S., Milovanovic, S.R., Spasic, S.D., Jones, D.R. and Spasic, M.B. Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Pharmacol. Rep. 59: 315-322, 2007.
21. Pescatello, L.S., Franklin, B.A., Fagard, R., Farquhar, W.B., Kelley, G.A. and Ray, C.A. American College of Sports Medicine position stand. Exercise and hypertension. Med. Sci. Sports Exerc. 36: 533-553, 2004.
22. Priviero, F.B., Zemse, S.M., Teixeira, C.E. and Webb, R.C. Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats. Am. J. Hypertens. 22: 493-499, 2009.
23. Rognmo, O., Hetland, E., Helgerud, J., Hoff, J. and Slordahl, S.A. High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur. J. Cardiovasc. Prev. Rehabil. 11: 216- 222, 2004.
24. Sekiguchi, F., Yanamoto, A. and Sunano, S. Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J. Smooth Muscle Res. 40: 65-74, 2004.
25. Sienkiewicz, P., Surazýnski, A., Pálka, J. and Miltyk, W. Nutritional concentration of genistein protects human dermal fibroblasts from oxidative stress-induced collagen biosynthesis inhibition through IGF-I receptor-mediated signaling. Acta Pol Pharm. 65: 203-211, 2008.
26. Sowers, J.R. Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology. Hypertension 29: 691- 699, 1997.
27. Sowers, J.R. Insulin resistance and hypertension. Am. J. Physiol. Heart Circ. Physiol. 286: H1597-H1602, 2004.
28. Steinberg, H.O., Brechtel, G., Johnson, A., Fineberg, N. and Baron, A.D. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J. Clin. Invest. 94: 1172-1179, 1994.
29. Swain, D.P. and Franklin, B.A. Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. Am. J. Cardiol. 97: 141-147, 2006.
30. Taddei, S. and Salvetti, A. Endothelial dysfunction in essential hypertension: clinical implications. J. Hypertens. 20: 1671-1674, 2002.
31. Thompson, P.D., Crouse, S.F., Goodpaster, B., Kelley, D., Moyna, N. and Pescatello, L. The acute versus the chronic response to exercise. Med. Sci. Sports Exerc. 33: S438-S445, 2001.
32. Vecchione, C., Colella, S., Fratta, L., Gentile, M.T., Selvetella, G., Frati, G., Trimarco, B. and Lembo, G. Impaired insulin-like growth factor I vasorelaxant effects in hypertension. Hypertension 37: 1480-1485, 2001.
33. Vinayagamoorthi, R., Bobby, Z. and Sridhar, M.G. Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance. J Endocrinol. 197: 287-296, 2008.
34. Walsh, M.F., Barazi, M., Pete, G., Muniyappa, R., Dunbar, J.C. and Sowers, J.R. Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. Endocrinology 137: 1798-1803, 1996.
35. Williams, P.T. Relationship of running intensity to hypertension, hypercholesterolemia, and diabetes. Med. Sci. Sports Exerc. 40: 1740-1748, 2008.
36. Yang, A.L., Chao, J.I. and Lee, S.D. Altered insulin-mediated and insulin-like growth factor-1-mediated vasorelaxation in aortas of obese Zucker rats. Int. J. Obes. (Lond) 31: 72-77, 2007.
37. Yang, A.L., Jen, C.J. and Chen, H.I. Effects of high-cholesterol diet and parallel exercise training on the vascular function of rabbit aortas: a time course study. J. Appl. Physiol. 95: 1194-1200, 2003.
38. Yang, A.L., Su, C.T., Lin, K.L., Chao, J.I., You, H.P. and Lee, S.D. Exercise training improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation in rat aortas. Life Sci. 79: 2017- 2021, 2006.
39. Yang, A.L., Su, C.T., Lin, K.L. and Lee, S.D. Enhancement of vascular function mediated by insulin and insulin-like growth factor-1 following single exercise session. Chin. J. Physiol. 51: 71- 77, 2008.
40. Yen, M.H., Yang, J.H., Sheu, J.R., Lee, Y.M. and Ding, Y.A. Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats. Life Sci. 57: 2205-2213, 1995.
41. Zecchin, H.G., Bezerra, R.M., Carvalheira, J.B., Carvalho-Filho, M.A., Metze, K., Franchini, K.G. and Saad, M.J. Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance-the obese middle-aged and the spontaneously hypertensive rats. Diabetologia 46: 479-491, 2003.