Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: A possible manifestation of dysfunctional subcutaneous adipose tissue

Clinical Endocrinology

Volumn 79, Issue 4, 2013, Pages 510-516

  Harada, Eisaku ^a   Mizuno, Yuji ^a   Katoh, Daisuke ^a   Kashiwagi, Yusuke ^a   Morita, Sumio ^a   Nakayama, Yoshiharu ^c   Yoshimura, Michihiro ^b   Masuzaki, Hiroaki ^d   Saito, Yoshihiko ^e   Yasue, Hirofumi ^a  

^a Kumamoto Kinoh Hospital   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Kumamoto Kinoh Hospital   (Japan)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

^e NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALDOSTERONE; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOREACTIVE INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RENIN; TRIACYLGLYCEROL;

ABDOMINAL FAT; ADIPOSE TISSUE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALDOSTERONE URINE LEVEL; ARTICLE; BLOOD SAMPLING; BODY MASS; CHOLESTEROL BLOOD LEVEL; COMPUTER ASSISTED TOMOGRAPHY; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; JAPANESE; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OBESITY; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION; WAIST CIRCUMFERENCE;

ADULT; ALANINE TRANSAMINASE; ALDOSTERONE; BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INSULIN; INTRA-ABDOMINAL FAT; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; RENIN; SUBCUTANEOUS FAT; TOMOGRAPHY, X-RAY COMPUTED; WAIST CIRCUMFERENCE;

EID: 84883549371     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12083     Document Type: Article

References (35)

1. Engeli, S., Schling, P., Gorzelniak. K., et al,. (2003) The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? International Journal of Biochemistry & Cell Biology, 35, 807-825.
2. Krug, A.W., &, Ehrhart-Bornstein, M., (2008) Aldosterone and metabolic syndrome: is increased aldosterone in metabolic syndrome patients an additional risk factor? Hypertension, 51, 1252-1258.
3. Whaley-Connell, A., Johnson, M.S., &, Sowers, J.R., (2010) Aldosterone: role in the cardiometabolic syndrome and resistant hypertension. Progress in Cardiovascular Diseases, 52, 401-409.
4. Hattangady, N.G., Olala, L.O., Bollag, W.B., et al,. (2012) Acute and chronic regulation of aldosterone production. Molecular and Cellular Endocrinology, 350, 151-162.
5. Williams, G.H., (2005) Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Failure Reviews, 10, 7-13.
6. Goodfriend, T.L., Ball, D.L., Egan, B.M., et al,. (2004) Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension, 43, 358-363.
7. Schinner, S., Willenberg, H.S., Krause, D., et al,. (2007) Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway. Int J Obes (Lond), 31, 864-870.
8. Jeon, J.H., Kim, K.Y., Kim, J.H., et al,. (2008) A novel adipokine CTRP1 stimulates aldosterone production. FASEB J, 22, 1502-1511.
9. Masuzaki, H., Ogawa, Y., Isse, N., et al,. (1995) Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes, 44, 855-858.
10. Sewter, C.P., Blows, F., Vidal-Puig, A., et al,. (2002) Regional differences in the response of human pre-adipocytes to PPAR-γ and RXR-α agonists. Diabetes, 51, 718-723.
11. Gesta, S., Tseng, Y.H., &, Kahn, C.R., (2007) Developmental origin of fat: tracking obesity to its source. Cell, 131, 242-256.
12. Yang, X., &, Smith, U., (2007) Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer? Diabetologia, 50, 1127-1139.
13. Fox, C.S., Massaro, J.M., Hoffmann, U., et al,. (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation, 116, 39-48.
14. Tchoukalova, Y.D., Votruba, S.B., Tchkonia, T., et al,. (2010) Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A, 107, 18226-18231.
15. Cornier, M.A., Després, J.P., Davis, N., et al,. American Heart Association Obesity Committee of the Council on Nutrition; Physical Activity and Metabolism; Council on Arteriosclerosis; Thrombosis and Vascular Biology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing, Council on Epidemiology and Prevention; Council on the Kidney in Cardiovascular Disease, and Stroke Council. (2011) Assessing adiposity: a scientific statement from the American heart association. Circulation, 124, 1996-2019.
16. Goodfriend, T.L., Kelley, D.E., Goodpaster, B.H., et al,. (1999) Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obesity Research, 73, 55-62.
17. Kobayashi, J., Tadokoro, N., Watanabe, M., et al,. (2002) A novel method of measuring intra-abdominal fat volume using helical computed tomography. International Journal of Obesity and Related Metabolic Disorders, 26, 398-402.
18. Shionoiri, H., Minamisawa, Y., Sugimoto, K., et al,. (1989) Fundamental and clinical studies on SPAC-S Aldosterone RIA Kit. Japanese Journal of Medicine and Pharmaceutical Science, 21, 293-302.
19. Hiroi, N., Yakuiji, F., Katayanagi, N., et al,. (1994) Evaluation of plasma renin activity using plasma renin activity(PRA) "SRL". Japanese Journal of Medicine and Pharmaceutical Science, 32, 81-85.
20. Matsuda, M., &, DeFronzo, R.A., (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care, 22, 1462-1470.
21. Katz M.H,. (2011) Setting up a multivariable analysis. In:, M.H. Katz, ed. Multivariable Analysis, 3rd edn. Cambridge University Press, New York, 97-102.
22. Després, J.P., Lemieux, I., Bergeron, J., et al,. (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1039-1049.
23. Unger, R.H., Clark, G.O., Scherer, P.E., et al,. (2010) Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta, 1801, 209-214.
24. Virtue, S., &, Vidal-Puig, A., (2010) Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochimica et Biophysica Acta, 1801, 338-349.
25. Bentley-Lewis, R., Adler, G.K., Perlstein, T., et al,. (2007) Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. Journal of Clinical Endocrinology and Metabolism, 92, 4472-4475.
26. Rossi, G.P., Belfiore, A., &, Bernini, G., et al,. (2008) Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. Journal of Clinical Endocrinology and Metabolism, 93, 2566-2571.
27. Kadowaki, T., Sekikawa, A., Murata, K., et al,. (2006) Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study. Int J Obes (Lond), 30, 1163-1165.
28. Wells, J.C., (2009) Ethnic variability in adiposity and cardiovascular risk: the variable disease selection hypothesis. International Journal of Epidemiology, 38, 63-71.
29. Yasue, S., Masuzaki, H., Okada, S., et al,. (2010) Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy. American Journal of Hypertension, 23, 425-431.
30. Briones, A.M., Cat, A.N., Callera, G.E., et al,. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension, 59, 1069-1078.
31. Suganami, T., &, Ogawa, Y., (2010) Adipose tissue macrophages: their role in adipose tissue remodeling. Journal of Leukocyte Biology, 88, 33-39.
32. Sun, K., Kusminski, C.M., &, Scherer, P.E., (2011) Adipose tissue remodeling and obesity. J Clin Invest, 121, 2094-2101.
33. Isakson, P., Hammarstedt, A., Gustafson, B., et al,. (2009) Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes, 58, 1550-1557.
34. Guo, C., Ricchiuti, V., Lian, B.Q., et al,. (2008) Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation, 117, 2253-2261.
35. Macotela, Y., Boucher, J., Tran, T.T., et al,. (2009) Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes, 58, 803-812.