Myocardial infarction and coronary microvascular obstruction: An intimate, but complicated relationship

Basic Research in Cardiology

Volumn 108, Issue 6, 2013, Pages

  Heusch, Gerd ^a   Kleinbongard, Petra ^a   Skyschally, Andreas ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Coronary microembolization; Ischemic postconditioning; No reflow phenomenon

Indexed keywords

ARTICLE; ATHEROSCLEROSIS; CELL DEATH; CORONARY ARTERY OBSTRUCTION; EDEMA; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE REPERFUSION; HUMAN; ISCHEMIC POSTCONDITIONING; MICROCIRCULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; REPERFUSION INJURY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; VASOCONSTRICTION;

FEMALE; HUMANS; ISCHEMIC POSTCONDITIONING; MALE; MYOCARDIAL INFARCTION;

EID: 84883532459     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0380-y     Document Type: Article

References (29)

1. Ambrosio G, Weisman HF, Mannisi JA, Becker LC (1989) Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation 80:1846-1861. doi: 10.1161/01.CIR.80.6.1837 (Pubitemid 20031716)
2. Barrabes JA, Inserte J, Agullo L, Alonso A, Mirabet M, Garcia-Dorado D (2010) Microvascular thrombosis: an exciting but elusive therapeutic target in reperfused acute myocardial infarction. Cardiovasc Hematol Disord Drug Targets 10:273-283. doi: 10.2174/187152910793743797
3. Garcia-Dorado D, Piper HM (2006) Postconditioning: reperfusion of "reperfusion injury" after hibernation. Cardiovasc Res 69:1-3. doi: 10.1016/j.cardiores.2005.11
4. Gregorini L, Marco J, Kozàkovà M, Palombo C, Anguissola GB, Marco I, Bernies M, Cassagneau B, Distante A, Bossi IM, Fajadet J, Heusch G (1999) α-Adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. Circulation 99:482-490. doi: 10.1161/01.CIR.99.4.482 (Pubitemid 29061862)
5. Hale SL, Dae MW, Kloner RA (2003) Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res 59:715-722. doi: 10.1016/S0008-6363(03)00456-5 (Pubitemid 38368688)
6. Heusch G (2004) Postconditioning: old wine in a new bottle? J Am Coll Cardiol 44:1111-1112. doi: org/10.1016/j.jacc2004.06.013 (Pubitemid 39165148)
7. Heusch G (2013) Cardioprotection: chances and challenges of its translation to the clinic. Lancet 381:166-175. doi: 10.1016/S0140-6736(12)60916- 7
8. Heusch G, Baumgart D, Camici P, Chilian W, Gregorini L, Hess O, Indolfi C, Rimoldi O (2000) α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans. Circulation 101:689-694. doi: 10.1161/01.CIR.101.6.689 (Pubitemid 30094742)
9. Heusch G, Kleinbongard P, Böse D, Levkau B, Haude M, Schulz R, Erbel R (2009) Coronary microembolization: from bedside to bench and back to bedside. Circulation 120:1822-1836. doi: 10.1161/CIRCULATIONAHA.109.888784
10. Heusch G, Kleinbongard P, Skyschally A, Levkau B, Schulz R, Erbel R (2012) The coronary circulation in cardioprotection: more than just one confounder. Cardiovasc Res 94:237-245. doi: 10.1093/cvr/cvr271
11. Judd RM, Lugo-Olivieri CH, Arai M, Kondo T, Croisille P, Lima JA, Mohan V, Becker LC, Zerhouni EA (1995) Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation 92:1902-1910. doi: 10.1161/01.CIR.92.7.1902
12. Kleinbongard P, Böse D, Baars T, Möhlenkamp S, Konorza T, Schöner S, Elter-Schulz M, Eggebrecht H, Degen H, Haude M, Levkau B, Schulz R, Erbel R, Heusch G (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108:344-352. doi: 10.1161/CIRCRESAHA. 110.235713
13. Kloner RA, Ganote CE, Jennings RB (1974) The "no-reflow" phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54:1496-1508. doi: 10.1172/JCI107898
14. Kloner RA, Rude RE, Carlson N, Maroko PR, DeBoer LWV, Braunwald E (1980) Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first? Circulation 62:945-952. doi: 10.1161/01.CIR.62.5.945 (Pubitemid 11225959)
15. Manciet LH, Poole DC, McDonagh PF, Copeland JG, Mathieu-Costello O (1994) Microvascular compression during myocardial ischemia: mechanistic basis for no-reflow phenomenon. Am J Physiol 266:H1541-H1550
16. Mewton N, Rapacchi S, Augeul L, Ferrera R, Loufouat J, Boussel L, Micolich A, Rioufol G, Revel D, Ovize M, Croisille P (2011) Determination of the myocardial area at risk with pre- versus post-reperfusion imaging techniques in the pig model. Basic Res Cardiol 106:1247-1257. doi: 10.1007/s00395-011-0214-8
17. Mewton N, Thibault H, Roubille F, Lairez O, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Cung TT, Finet G, Angoulvant D, Revel D, Bonnefoy-Cudraz E, Elbaz M, Piot C, Sahraoui I, Croisille P, Ovize M. Ischemic postconditioning attenuates no-reflow in STEMI patients. Basic Res Cardiol 108:383. doi: 10.1007/s00395-013-0383-8
18. Nassenstein K, Breuckmann F, Bucher C, Kaiser G, Konorza T, Schäfer L, Konietzka I, de Greiff A, Heusch G, Erbel R, Barkhausen J (2008) How much myocardial damage is necessary to enable detection of focal late gadolinium enhancement at cardiac MR imaging? Radiology 249:829-835. doi: 10.1148/radiol.2493080457
19. Niccoli G, Burzotta F, Galiuto L, Crea F (2009) Myocardial no-reflow in humans. J Am Coll Cardiol 54:281-292. doi: 10.1016/j.jacc.2009.03.054
20. Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R (2010) Postconditioning and protection from reperfusion injury: where do we stand? Cardiovasc Res 87:406-423. doi: 10.1093/cvr/cvq129
21. Reffelmann T, Hale SL, Li G, Kloner RA (2002) Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion. Am J Physiol Heart Circ Physiol 282:H766-H772. doi: 10.1152/ajpheart.00767.2001
22. Reffelmann T, Kloner RA (2002) Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit. Am J Physiol Heart Circ Physiol 283:H1099-H1107. doi: ajpheart.00270.2002
23. Rochitte CE, Lima JAC, Bluemke DA, Reeder SB, McVeigh ER, Furuta T, Becker LC, Melin JA (1998) Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction. Circulation 98:1006-1014. doi: 10.1161/01.CIR.98.10.1006 (Pubitemid 28446654)
24. Skyschally A, Walter B, Heusch G (2012) Coronary microembolization during early reperfusion: infarct extension, but protection by ischemic postconditioning. Eur Heart J. doi: 10.1093/eurheartj/ehs434
25. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit J-F, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M (2005) Postconditioning the human heart. Circulation 112:2143-2148. doi: 10.1161/CIRCULATIONAHA.105.558122 (Pubitemid 41475808)
26. Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, Cung TT, Bonnefoy E, Angoulvant D, Aupetit JF, Finet G, Andre-Fouet X, Macia JC, Raczka F, Rossi R, Itti R, Kirkorian G, Derumeaux G, Ovize M (2008) Long-term benefit of postconditioning. Circulation 117:1037-1044. doi: 10.1161/CIRCULATIONAHA.107. 729780
27. Wince WB, Kim RJ (2010) Molecular imaging: T2-weighted CMR of the area at risk-a risky business? Nat Rev Cardiol 7:547-549. doi: 10.1038/nrcardio.2010. 124
28. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121-1135. doi: 10.1056/NEJMra071667 (Pubitemid 47443217)
29. Zhao Z-Q, Corvera JS, Halkos ME, Kerendi F, Wang N-P, Guyton RA, Vinten-Johansen J (2003) Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285:H579-H588. doi: 10.1152/ajpheart.01064.2002