Coronary microembolization during early reperfusion: Infarct extension, but protection by ischaemic postconditioning

European Heart Journal

Volumn 34, Issue 42, 2013, Pages 3314-3321

  Skyschally, Andreas ^a   Walter, Barbara ^a   Heusch, Gerd ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Acute myocardial infarction; Cardioprotection; Coronary circulation; Microembolization; Reperfusion; Reperfusion injury

Indexed keywords

RADIOACTIVE MICROSPHERE; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; CORONARY HEMODYNAMICS; CORONARY MICROEMBOLIZATION; CORONARY RISK; EXPERIMENTAL PIG; HEART INFARCTION SIZE; HEART PROTECTION; ISCHEMIC POSTCONDITIONING; MICROEMBOLISM; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ACUTE MYOCARDIAL INFARCTION; CARDIOPROTECTION; CORONARY CIRCULATION; MICROEMBOLIZATION; REPERFUSION; REPERFUSION INJURY;

ANIMALS; DISEASE MODELS, ANIMAL; EMBOLISM; HEART DISEASES; ISCHEMIC POSTCONDITIONING; MICROSPHERES; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; SWINE; SWINE, MINIATURE;

EID: 84890448698     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs434     Document Type: Article

References (38)

1. Kloner RA, Ganote CE, Jennings RB. The 'no-reflow' phenomenon after temporary coronary occlusion in the dog. J Clin Invest 1974;54:1496-1508.
2. Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol 2009;54:281-292.
3. Schwartz BG, Kloner RA. Coronary no reflow. J Mol Cell Cardiol 2012;52: 873-882.
4. Ganesha Babu G, Malcolm WJ, Yellon DM, Hausenloy DJ. Peri-procedural myocardial injury during percutaneous coronary intervention: An important target for cardioprotection. Eur Heart J 2011;32:23-31.
5. Heusch G, Kleinbongard P, Böse D, Levkau B, Haude M, Schulz R, Erbel R. Coronary microembolization: from bedside to bench and back to bedside. Circulation 2009;120:1822-1836.
6. Barrabés JA, Garcia-Dorado D, Mirabet M, Inserte J, Argulló L, Soriano B, Massaguer A, Padilla F, Lidón R-M, Soler-Soler J. Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia. J Am Coll Cardiol 2005;45:293-299.
7. Leineweber K, Böse D, Vogelsang M, Haude M, Erbel R, Heusch G. Intense vasoconstriction in response to aspirate from stented saphenous vein aortocoronary bypass grafts. J Am Coll Cardiol 2006;47:981-986.
8. Kleinbongard P, Böse D, Baars T, Möhlenkamp S, Konorza T, Schöner S, Elter-Schulz M, Eggebrecht H, Degen H, Haude M, Levkau B, Schulz R, Erbel R, Heusch G. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 2010;108:344-352.
9. Ambrosio G, Weisman HF, Mannisi JA, Becker LC. Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation 1989;80:1846-1861.
10. Driesen RB, Zalewski J, Driessche NV, Vermeulen K, Bogaert J, Sipido KR, Van de WF, Claus P. Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion. Cardiovasc Pathol 2011;21:129-131.
11. Porto I, Biasucci LM, De Maria GL, Leone AM, Niccoli G, Burzotta F, Trani C, Tritarelli A, Vergallo R, Liuzzo G, Crea F. Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention. Eur Heart J 2012;33:2928-2938.
12. Heusch G, Kleinbongard P, Skyschally A, Levkau B, Schulz R, Erbel R. The coronary circulation in cardioprotection: more than just one confounder. Cardiovasc Res 2012;94:237-245.
13. Heusch G, Skyschally A, Schulz R. The in-situ pig heart with regional ischemia/reperfusion -ready for translation. J Mol Cell Cardiol 2011;50:951-963.
14. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007;357: 1121-1135.
15. Hausenloy DJ, Baxter G, Bell R, Botker HE, Davidson SM, Downey J, Heusch G, Kitakaze M, Lecour S, Mentzer R, Mocanu MM, Ovize M, Schulz R, Shannon R, Walker M, Walkinshaw G, Yellon DM. Translating novel strategies for cardioprotection: the Hatter Workshop recommendations. Basic Res Cardiol 2010;105: 677-686.
16. Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R. Postconditioning and protection from reperfusion injury: where do we stand? Cardiovasc Res 2010;87: 406-423.
17. Zhao Z-Q, Corvera JS, Halkos ME, Kerendi F, Wang N-P, Guyton RA, Vinten-Johansen J. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 2003;285:H579-H588.
18. Skyschally A, van Caster P, Iliodromitis EK, Schulz R, Kremastinos DT, Heusch G. Ischemic postconditioning -experimental models and protocol algorithms. Basic Res Cardiol 2009;104:469-483.
19. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit J-F, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M. Postconditioning the human heart. Circulation 2005;112:2143-2148.
20. Heusch G. Reduction of infarct size by ischaemic post-conditioning in humans: fact or fiction Eur Heart J 2012;33:13-15.
21. Ma X, Zhang X, Li C, Luo M. Effect of postconditioning on coronary blood flow velocity and endothelial function and LV recovery after myocardial infarction. J Interv Cardiol 2006;19:367-375.
22. Post H, Schulz R, Vahlhaus C, Hüsing J, Hirche H, Gallagher KP, Heusch G. Impact of resting and ischemic blood flow on infarct probability in ischemic preconditioning -A new approach to infarct size-blood flow data by logistic regression. J Mol Cell Cardiol 1998;30:2719-2728.
23. Falk E. Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 1985;71:699-708.
24. Davies MJ, Thomas AC, Knapman PA, Hangartner Jr. Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death. Circulation 1986;73:418-427.
25. Neumann T, Konietzka I, van de Sand A, Aker S, Schulz R, Heusch G. Identification of necrotic tissue by phase-contrast microscopy at an early stage of acute myocardial infarction. Lab Invest 2000;80:981-982.
26. Dörge H, Schulz R, Belosjorow S, Post H, van de Sand A, Konietzka I, Frede S, Hartung T, Vinten-Johansen J, Youker KA, Entman ML, Erbel R, Heusch G. Coronary microembolization: the role of TNFa in contractile dysfunction. J Mol Cell Cardiol 2002;34:51-62.
27. Heusch G, Musiolik J, Gedik N, Skyschally A. Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion. Circ Res 2011;109:1302-1308.
28. Skyschally A, van Caster P, Boengler K, Gres P, Musiolik J, Schilawa D, Schulz R, Heusch G. Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res 2009;104:15-18.
29. Christian TF, Berger PB, O'Connor MK, Hodge DO, Gibbons RJ. Threshold values for preserved viability with a noninvasive measurement of collateral blood flow during acute myocardial infarction treated by direct coronary angioplasty. Circulation 1999;100:2392-2395.
30. Skyschally A, Schulz R, Gres P, Konietzka I, Martin C, Haude M, Erbel R, Heusch G. Coronary microembolization does not induce acute preconditioning against infarction in pigs -The role of adenosine. Cardiovasc Res 2004;63:313-322.
31. Dörge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G. Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation. Am J Physiol Heart Circ Physiol 2000;279: H2587-H2592.
32. Kleinbongard P, Konorza T, Böse D, Baars T, Haude M, Erbel R, Heusch G. Lessons from human coronary aspirate. J Mol Cell Cardiol 2011;52:890-896.
33. Niccoli G, Lanza GA, Shaw S, Romagnoli E, Gioia D, Burzotta F, Trani C, Mazzari MA, Mongiardo R, De Vita M, Rebuzzi AG, Lüscher TF, Crea F. Endothelin-1 and acutemyocardial infarction: A no-reflow mediator after successful percutaneous myocardial revascularization. Eur Heart J 2006;27:1793-1798.
34. Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy-Cudraz E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2012;59:2175-2181.
35. Heusch G. Cardioprotection -chances and challenges of its translation to the clinic. Lancet; doi: 10.1016/S0140-6736(12)60916-7. Published online ahead of print 19 October 2012.
36. Whittaker P, Przyklenk K. Reduction of infarct size in vivo with ischemic preconditioning: mathematical evidence for protection via non-ischemic tissue. Basic Res Cardiol 1994;89:6-15.
37. Heusch G, Schulz R. Perfusion-contraction match and mismatch. Basic Res Cardiol 2001;96:1-10.
38. Skyschally A, Gres P, Hoffmann S, Haude M, Erbel R, Schulz R, Heusch G. Bidirectional role of tumor necrosis factor-A in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction. Circ Res 2007;100:140-146.