Effect of a natural mutation in the 5′ untranslated region on the translational control of p53 mRNA

Oncogene

Volumn 32, Issue 35, 2013, Pages 4148-4159

  Khan, D ^a   Sharathchandra, A ^a   Ponnuswamy, A ^a   Grover, R ^a   Das, S ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

internal initiation; IRES; p53 mRNA; PTB; SNP; translational control

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE; DNA; DOXORUBICIN; IRES TRANS ACTING FACTOR; MESSENGER RNA; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN P53; RNA; THREONINE; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; EX VIVO STUDY; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDIATOR; MELANOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REPORTER GENE; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; TUMOR CELL; TUMOR SUPPRESSOR GENE;

5' UNTRANSLATED REGIONS; ANIMALS; BINDING SITES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; HUMANS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYPYRIMIDINE TRACT-BINDING PROTEIN; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84883488226     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.422     Document Type: Article

References (28)

1. Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009; 9: 749-758.
2. Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009; 137: 413-431.
3. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991; 253: 49-53.
4. Yang DQ, Halaby MJ, Zhang Y. The identification of an internal ribosomal entry site in the 50-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. Oncogene 2006; 25: 4613-4619.
5. Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 2005; 123: 49-63.
6. Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K, Vojtesek B et al. Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene 2006; 25: 6936-6947.
7. Ray PS, Grover R, Das S. Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep 2006; 7: 404-410.
8. Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S et al. Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell 2010; 38: 78-88.
9. Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L et al. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res 2010; 70: 6026-6035.
10. Montanaro L, Calienni M, Bertoni S, Rocchi L, Sansone P, Storci G et al. Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation. Cancer Res 2010; 70: 4767-4777.
11. Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell 2003; 11: 757-771.
12. Lewis SM, Veyrier A, Hosszu Ungureanu N, Bonnal S, Vagner S, Holcik M. Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation. Mol Biol Cell 2007; 18: 1302-1311.
13. Grover R, Ray PS, Das S. Polypyrimidine tract binding protein regulates IRESmediated translation of p53 isoforms. Cell Cycle 2008; 7: 2189-2198.
14. Grover R, Candeias MM, Fahraeus R, Das S. p53 and little brother p53/47: linking IRES activities with protein functions. Oncogene 2009; 28: 2766-2772.
15. Whibley C, Pharoah PD, Hollstein M. p53 polymorphisms: cancer implications. Nat Rev Cancer 2009; 9: 95-107.
16. Grover R, Sharathchandra A, Ponnuswamy A, Khan D, Das S. Effect of mutations on the p53 IRES RNA structure: implications for de-regulation of the synthesis of p53 isoforms. RNA Biol 2011; 8: 132-142.
17. Soto JL, Cabrera CM, Serrano S, Lopez-Nevot MA. Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B. BMC Cancer 2005; 5: 36.
18. Lim YP, Lim TT, Chan YL, Song AC, Yeo BH, Vojtesek B et al. The p53 knowledgebase: an integrated information resource for p53 research. Oncogene 2007; 26: 1517-1521.
19. Kim JH, Paek KY, Choi K, Kim TD, Hahm B, Kim KT et al. Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phasedependent manner. Mol Cell Biol 2003; 23: 708-720.
20. Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N et al. P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol 2008; 10: 1098-1105.
21. Schuler M, Bossy-Wetzel E, Goldstein JC, Fitzgerald P, Green DR. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 2000; 275: 7337-7342.
22. Ara S, Lee PS, Hansen MF, Saya H. Codon 72 polymorphism of the TP53 gene. Nucleic Acids Res 1990; 18: 4961.
23. Li X, Dumont P, Della Pietra A, Shetler C, Murphy ME. The codon 47 polymorphism in p53 is functionally significant. J Biol Chem 2005; 280: 24245-24251.
24. Pudi R, Srinivasan P, Das S. La protein binding at the GCAC site near the initiator AUG facilitates the ribosomal assembly on the hepatitis C virus RNA to influence internal ribosome entry site-mediated translation. J Biol Chem 2004; 279: 29879-29888.
25. Bhattacharyya S, Das S. An apical GAGA loop within 5' UTR of the coxsackievirus B3 RNA maintains structural organization of the IRES element required for efficient ribosome entry. RNA Biol 2006; 3: 60-68.
26. Wagner EJ, Garcia-Blanco MA. RNAi-mediated PTB depletion leads to enhanced exon definition. Mol Cell 2002; 10: 943-949.
27. Ray AJ, Hoyen CK, Das SM, Eckstein EC, Donskey CJ. Undetected vancomycinresistant enterococcus stool colonization in a veterans affairs hospital using a Clostridium difficile-focused surveillance strategy. Infect Control Hosp Epidemiol 2002; 23: 474-477.
28. Hellman LM, Fried MG. Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc 2007; 2: 1849-1861.