Trauma and tranexamic acid

Medical Journal of Australia

Volumn 199, Issue 5, 2013, Pages 310-311

  Gruen, Russell L ^a,b   Jacobs, Ian G ^c,d   Reade, Michael C ^e,f  

^a MONASH UNIVERSITY   (Australia)

^b NATIONAL TRAUMA RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d ST JOHN AMBULANCE WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f Australian Defence Force Joint Health Command   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

ACUTE TRAUMATIC COAGULOPATHY; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; CLINICAL PROTOCOL; DEEP VEIN THROMBOSIS; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; EDITORIAL; EVIDENCE BASED MEDICINE; HEALTH CARE ACCESS; HUMAN; INJURY; LUNG EMBOLISM; PATIENT SELECTION; RISK BENEFIT ANALYSIS; TREATMENT OUTCOME;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; HEMORRHAGE; HUMANS; THROMBOSIS; TRANEXAMIC ACID; WOUNDS AND INJURIES;

EID: 84883485463     PISSN: 0025729X     EISSN: 13265377     Source Type: Journal    
DOI: 10.5694/mja13.10747     Document Type: Editorial

References (11)

1. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376: 23-32.
2. Pusateri AE, Weiskopf RB, Bebarta V, et al. Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock 2013; 39: 121-126.
3. Napolitano LM, Cohen MJ, Cotton BA, et al. Tranexamic acid in trauma: how should we use it? J Trauma Acute Care Surg 2013; 74: 1575-1586.
4. Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012; 344: e3054.
5. Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011; 377: 1096-1101.e1-2.
6. Shakur H, Roberts I, Piot P, et al. A promise to save 100 000 trauma patients. Lancet 2012; 380: 2062-2063.
7. Gruen RL, Mitra B. Tranexamic acid for trauma. Lancet 2011; 377: 1052-1054.
8. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012; 147: 113-119.
9. Mitra B, Cameron PA, Gruen RL. Aggressive fresh frozen plasma (FFP) with massive blood transfusion in the absence of acute traumatic coagulopathy. Injury 2012; 43: 33-37.
10. Ioannidis JP. Contradicted and initially stronger effects in highly cited clinical research. JAMA 2005; 294: 218-228.
11. Goldberger JJ, Buxton AE. Personalized medicine vs guideline-based medicine. JAMA 2013; 309: 2559-2560.