Changes in the phospholipid fatty acid composition of the lipid droplet during the differentiation of 3T3-L1 adipocytes

Journal of Biochemistry

Volumn 154, Issue 3, 2013, Pages 281-289

  Arisawa, Kotoko ^a   Ichi, Ikuyo ^a   Yasukawa, Yukiko ^a   Sone, Yasuko ^a   Fujiwara, Yoko ^a  

^a OCHANOMIZU UNIVERSITY   (Japan)

Author keywords

adipocyte; fatty acid; lipid droplet; phospholipid

Indexed keywords

FAT DROPLET; FATTY ACID; MONOUNSATURATED FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; TRIACYLGLYCEROL;

ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; LIPID ANALYSIS; LIPID COMPOSITION; LIPID MONOLAYER; MICROSOME; PHOSPHOLIPID BILAYER;

ADIPOCYTE; FATTY ACID; LIPID DROPLET; PHOSPHOLIPID;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CHROMATOGRAPHY, THIN LAYER; FATTY ACIDS; FATTY ACIDS, UNSATURATED; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIPID METABOLISM; MICE; ORGANELLES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES;

EID: 84883473333     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvt051     Document Type: Article

References (33)

1. Galic, S., Oakhill, J.S., and Steinberg, G.R. (2010) Adipose tissue as an endocrine organ. Mol. Cell. Endocrinol. 316, 129-139
2. Grundy, S.M., Brewer, H.B. Jr., Cleeman, J.I., Smith, S.C. Jr., and Lenfant, C. (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109, 433-438
3. Rajala, M.W. and Scherer, P.E. (2003) Minireview: The adipocyte - at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144, 3765-3773
4. Martin, S. and Parton, R.G. (2006) Lipid droplets: A unified view of a dynamic organelle. Nat. Rev. Mol. Cell. Biol. 7, 373-378
5. Ploegh, H.L. (2007) A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature 448, 435-438
6. Gross, D.A., Zhan, C., and Silver, D.L. (2011) Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc. Natl Acad. Sci. USA 108, 19581-19586
7. Kadereit, B., Kumar, P., Wang, W.J., Miranda, D., Snapp, E.L., Severina, N., Torregroza, I., Evans, T., and Silver, D.L. (2008) Evolutionarily conserved gene family important for fat storage. Proc. Natl Acad. Sci. USA 105, 94-99
8. Yang, H., Galea, A., Sytnyk, V., and Crossley, M. (2012) Controlling the size of lipid droplets: Lipid and protein factors. Curr. Opin. Cell. Biol. 24, 509-516
9. Samsa, M.M., Mondotte, J.A., Iglesias, N.G., Assunçä o-Miranda, I., Barbosa-Lima, G., Da Poian, A.T., Bozza, P.T., and Gamarnik, A.V. (2009) Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog. 5, e1000632
10. Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas, M., Bartenschlager, R., Wakita, T., Hijikata, M., and Shimotohno, K. (2007) The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell. Biol. 9, 1089-1097
11. Fei, W., Shui, G., Gaeta, B., Du, X., Kuerschner, L., Li, P., Brown, A.J., Wenk, M.R., Parton, R.G., and Yang, H. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J. Cell. Biol. 180, 473-482
12. Guo, Y., Walther, T.C., Rao, M., Stuurman, N., Goshima, G., Terayama, K., Wong, J.S., Vale, R.D., Walter, P., and Farese, R.V. (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453, 657-661
13. Boström, P., Andersson, L., Rutberg, M., Perman, J., Lidberg, U., Johansson, B.R., Fernandez-Rodriguez, J., Ericson, J., Nilsson, T., Borén, J., and Olofsson, S.O. (2007) SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat. Cell. Biol. 9, 1286-1293
14. Murphy, S., Martin, S., and Parton, R.G. (2010) Quantitative analysis of lipid droplet fusion: Inefficient steady state fusion but rapid stimulation by chemical fusogens. PLoS ONE 5, e15030
15. Brasaemle, D.L., Barber, T., Wolins, N.E., Serrero, G., Blanchette-Mackie, E.J., and Londos, C. (1997) Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38, 2249-2263
16. Miura, S., Gan, J.W., Brzostowski, J., Parisi, M.J., Schultz, C.J., Londos, C., Oliver, B., and Kimmel, A.R. (2002) Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277, 32253-32257
17. Puri, V., Konda, S., Ranjit, S., Aouadi, M., Chawla, A., Chouinard, M., Chakladar, A., and Czech, M.P. (2007) Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J. Biol. Chem. 282, 34213-34218
18. Keller, P., Petrie, J.T., De Rose, P., Gerin, I., Wright, W.S., Chiang, S.H., Nielsen, A.R., Fischer, C.P., Pedersen, B.K., and MacDougald, O.A. (2008) Fat-specific protein 27 regulates storage of triacylglycerol. J. Biol. Chem. 283, 14355-14365
19. Spector, A.A. and Yorek, M.A. (1985) Membrane lipid composition and cellular function. J. Lipid Res. 26, 1015-1035
20. Leber, R., Zinser, E., Zellnig, G., Paltauf, F., and Daum, G. (1994) Characterization of lipid particles of the yeast, Saccharomyces cerevisiae. Yeast 10, 1421-1428
21. Tauchi-Sato, K., Ozeki, S., Houjou, T., Taguchi, R., and Fujimoto, T. (2002) The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J. Biol. Chem. 277, 44507-44512
22. Bligh, E.G. and Dyer, W.J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917
23. Bartlett, G.R. (1959) Phosphorus assay in column chromatography. J. Biol. Chem. 234, 466-468
24. Student, A.K., Hsu, R.Y., and Lane, M.D. (1980) Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J. Biol. Chem. 255, 4745-4750
25. Mori, T., Sakaue, H., Iguchi, H., Gomi, H., Okada, Y., Takashima, Y., Nakamura, K., Nakamura, T., Yamauchi, T., Kubota, N., Kadowaki, T., Matsuki, Y., Ogawa, W., Hiramatsu, R., and Kasuga, M. (2005) Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 280, 12867-12875
26. Rosen, E.D. and Spiegelman, B.M. (2001) PPARgamma: A nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276, 37731-37734
27. Guillou, H., Zadravec, D., Martin, P.G., and Jacobsson, A. (2010) The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res. 49, 186-199
28. Paton, C.M. and Ntambi, J.M. (2009) Biochemical and physiological function of stearoyl-CoA desaturase. Am. J. Physiol. Endocrinol. Metab. 297, E28-E37
29. Shimano, H. (2012) Novel qualitative aspects of tissue fatty acids related to metabolic regulation: Lessons from Elovl6 knockout. Prog. Lipid Res. 51, 267-271
30. Hapala, I., Marza, E., and Ferreira, T. (2011) Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation. Biol. Cell 103, 271-285
31. Carman, G.M. and Han, G.S. (2009) Regulation of phospholipid synthesis in yeast. J. Lipid Res. 50, S69-S73
32. Vance, J.E. and Vance, D.E. (2004) Phospholipid biosynthesis in mammalian cells. Biochem. Cell Biol. 82, 113-128
33. Moessinger, C., Kuerschner, L., Spandl, J., Shevchenko, A., and Thiele, C. (2011) Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. J. Biol. Chem. 286, 21330-21339