Preparation of fiber-microsphere scaffolds for loading bioactive substances in gradient amounts

Chinese Science Bulletin

Volumn 58, Issue 27, 2013, Pages 3415-3421

  Tang, GongWen ^a   Zhao, YunHui ^a   Yuan, XiaoYan ^a  

^a TIANJIN UNIVERSITY   (China)

Author keywords

bioactive substances; electrospinning; electrospraying; gradient scaffolds

Indexed keywords

BOVINAE;

EID: 84883446497     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-013-5974-0     Document Type: Article

References (22)

1. McClure M J, Wolfe P S, Simpson D G, et al. The use of air-flow impedance to control fiber deposition patterns during electrospinning. Biomaterials, 2012, 33: 771-779.
2. Phipps M C, Clem W C, Grunda J M, et al. Increasing the pore sizes of bone-mimetic electrospun scaffolds comprised of polycaprolactone, collagen I and hydroxyapatite to enhance cell infiltration. Bioma-terials, 2012, 33: 524-534.
3. Kim T G, Lee D S, Park T G. Controlled protein release from electrospun biodegradable fiber mesh composed of poly(e{open}-caprolactone) and poly(ethylene oxide). Int J Pharm, 2007, 338: 276-283.
4. Zeng J, Kang Y, Su G. Formation of drug-loaded electrospun twin fibers. Chin Sci Bull, 2012, 57: 1275-1279.
5. Yang Y, Li X, Qi M, et al. Release pattern and structural integrity of lysozyme encapsulated in core-sheath structured poly(dl-lactide) ultrafine fibers prepared by emulsion electrospinning. Eur J Pharm Biopharm, 2008, 69: 106-116.
6. Wei K, Li Y, Mugishima H, et al. Fabrication of core-sheath structured fibers for model drug release and tissue engineering by emulsion electrospinning. Biotechnol J, 2012, 7: 677-685.
7. Thuy T T N, Ghosh C, Hwang S G, et al. Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system. Int J Pharm, 2012, 439: 296-306.
8. Yang J M, Zha L S, Yu D G, et al. Coaxial electrospinning with acetic acid for preparing ferulic acid/zein composite fibers with improved drug release profiles. Colloid Surf B Biointerfaces, 2013, 102: 737-743.
9. Viry L, Moulton S E, Romeo T, et al. Emulsion-coaxial electros-pinning: Designing novel architectures for sustained release of highly soluble low molecular weight drugs. J Mater Chem, 2012, 22: 11347-11353.
10. Seidi A, Ramalingam M, Elloumi-Hannachi I, et al. Gradient biomaterials for soft-to-hard interface tissue engineering. Acta Biomater, 2011, 7: 1441-1451.
11. Bonani W, Motta A, Migliaresi C, et al. Biomolecule gradient in micropatterned nanofibrous scaffold for spatiotemporal release. Langmuir, 2012, 28: 13675-13687.
12. Zhang X, Gao X H, Jiang L, et al. Flexible generation of gradient electrospinning nanofibers using a microfluidic assisted approach. Langmuir, 2012, 28: 10026-10032.
13. Tang G W, Zhang H, Zhao Y H, et al. Preparation of PLGA scaffolds with graded pores by using a gelatin-microsphere template as porogen. J Biomater Sci Polym Ed, 2012, 23: 2241-2257.
14. Tang G W, Zhang H, Zhao Y H, et al. Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres. J Mater Sci Mater Med, 2012, 23: 419-429.
15. Du F Y, Wang H, Zhao W, et al. Gradient nanofibrous chitosan/poly e{open}-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials, 2012, 33: 762-770.
16. Sundararaghavan H G, Burdick J A. Gradients with depth in electrospun fibrous scaffolds for directed cell behavior. Biomacromolecules, 2011, 12: 2344-2350.
17. Jaworek A. Electrostatic micro- and nanoencapsulation and electroemulsification: A brief review. J Microencapsul, 2008, 25: 443-468.
18. Fantini D, Zanetti M, Costa L. Polystyrene microspheres and nanospheres produced by electrospray. Macromol Rapid Commun, 2006, 27: 2038-2042.
19. Pareta R, Edirisinghe M J. A novel method for the preparation of biodegradable microspheres for protein drug delivery. J R Soc Interface, 2006, 3: 573-582.
20. Young C J, Poole-Warren L A, Martens P J. Combining submerged electrospray and UV photopolymerization for production of synthetic hydrogel microspheres for cell encapsulation. Biotechnol Bioeng, 2012, 109: 1561-1570.
21. Chen H Y, Zhao Y, Jiang L. Compound-fluidic electrospray: An efficient method for the fabrication of microcapsules with multicompartment structure. Chin Sci Bull, 2009, 54: 3147-3153.
22. Xie J, Wang C H. Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor cone-jet mode. Biotechnol Bioeng, 2007, 97: 1278-1290.