Inhibitory Effect of Metformin and Pyridoxamine in the Formation of Early, Intermediate and Advanced Glycation End-Products

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Ahmad, Saheem ^a,c   Shahab, Uzma ^b   Baig, Mohd Hassan ^a   Khan, Mohd Sajid ^a   Khan, M Salman ^a   Srivastava, A K ^a   Saeed, Mohd ^a   Moinuddin, ^b  

^a INTEGRAL UNIVERSITY   (India)

^b ALIGARH MUSLIM UNIVERSITY   (India)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; FREE RADICAL; HUMAN SERUM ALBUMIN; LACTATE DEHYDROGENASE; METFORMIN; PYRIDOXAMINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; INCUBATION TIME; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SPECTROSCOPY;

GLYCOSYLATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; METFORMIN; PYRIDOXAMINE;

EID: 84883426144     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072128     Document Type: Article

References (43)

1. Akhtar F, Khan MS, Shahab U, Moinuddin, Ahmad S, (2013) Bio-Physical characterization of ribose induced glycation: A mechanistic study on DNA perturbations. Int J Biol Macro 58: 206-210.
2. Shane AA, Loeser RF, (2010) Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol 24: 15-26.
3. Ahmad S, Moinuddin, Dixit K, Shahab U, Alam K, et al. (2011) Genotoxicity and immunogenicity of DNA-advanced glycation end products formed by methylglyoxal and lysine in presence of Cu2+. Biochem Biophys Res Commun 407: 568-574.
4. Mustafa I, Ahmad S, Dixit K, Moinuddin, Ahmad J, et al. (2012) Glycated human DNA is a preferred antigen for anti-DNA antibodies in diabetic patients. Diabetes Res Clin Pract 95: 98-104.
5. Synold T, Xi B, Wuenschell GE, Tamae D, Figarola JL, et al. (2008) Advanced glycation end products of DNA: Quantification of N2-(1- Carboxyethyl)-20-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Chem Res Toxicol 21: 2148-2155.
6. Ahmad I, Ahmad S, Moinuddin (2011) Preferential recognition of methylglyoxal-modified calf thymus DNA by circulating antibodies in cancer patients. Indian J. Biochem. Biophys. 48: 290-296.
7. Tan D, Wang D, Lo CY, Sang S, Ho CT, (2008) Methylglyoxal: Its presence in beverages and potential scavengers. Ann N Y Acad Sci 1126: 72-75.
8. Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, et al. (2007) Circulating glycotoxins and dietary advanced glycation end products: Two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci 62: 427-433.
9. Nakamura K, Yamagishi S, Adachi H, Matsui H, Kurita-Nakamura Y, et al. (2008) Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes. Diabetes Metab Res Rev 24: 109-114.
10. Voziyan PA, Khalifah RG, Thibaudeau C, Yildiz A, Jacob J, et al. (2003) Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions. J Biol Chem 278: 46616-46624.
11. Nagai R, Murray DB, Metz TO, Baynes JW, (2012) Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes 61: 549-559.
12. Engelen L, Stehouwer CDA, Schalkwijk CG (2012) Current therapeutic interventions in the glycation pathway: evidence from clinical studies Diabetes. Obes Metab. doi:10.1111/dom.12058.
13. Ruggiero-Lopez D, Lecomte M, Moinet G, Patereau G, Lagarde M, et al. (1999) Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation. Biochem Pharmacol 58: 1765-1773.
14. Horbach S, Strohhäcker J, Welle R, de Graaf A, Sahm H, (1994) Enzymes involved in the formation of glycerol 3-phosphate and the by-products dihydroxycetone and glycerol in Zymomonas mobilis. FEMS Microbiol Lett 120: 37-44.
15. Arif B, Ashraf JM, Moinuddin, Ahmad J, Arif Z, et al. (2012) Structural and immunological characterization of Amadori-rich human serum albumin: Role in diabetes mellitus. Arch Biochem Biophys 522: 17-25.
16. Ahmad S, Moinuddin, Ali A, (2012) Immunological studies on glycated human IgG. Life Sci 90: 980-987.
17. Ashraf JM, Arif B, Dixit K, Moinuddin, Alam K, (2012) Physicochemical analysis of structural changes in DNA modified with glucose. Int J Biol Macromol 51: 604-611.
18. Kawashima K, Itoh H, Chibatar I, (1980) Nonenzymatic browning reactions of dihydroxyacetone with amino acids or their esters. Agric Biol Chem 44: 1595.
19. Petersen AB, Wulf HC, Gniadecki R, Gajkowska B, (2004) Dihydroxyacetone the active browning ingredient in sunless tanning lotions, induces DNA damage, cell cycle block and apoptosis in cultured HaCaT keratinocytes. Mutat Res 560: 173-186.
20. Shahab U, Moinuddin, Ahmad S, Dixit K, Abidi SM, et al. (2012) Acquired immunogenicity of human DNA damaged by N-hydroxy-N-acetyl-4-aminobiphenyl. IUBMB Life 64: 340-345.
21. Shahab U, Moinuddin, Ahmad S, Dixit K, Habib S, et al. (2013) Genotoxic Effect of N-Hydroxy-4-Acetylaminobiphenyl on Human DNA: Implications in Bladder Cancer. PLoS ONE 8(1): e53205.
22. Shahab U, Ahmad S, Moinuddin, Dixit K, Habib S, et al. (2012) Hydroxyl radical modification of collagen type II increases its arthritogenicity and immunogenicity. PLoS ONE 7(2): e31199.
23. Moinuddin, Dixit K, Ahmad S, Shahab U, Habib S,et al. (2012) Human dna damage by the synergistic action of 4-aminobiphenyl and nitric oxide: An immunochemical study. Environ Toxicol doi:10.1002/tox.21782.
24. Losso JN, Bawadi HA, Chintalapati M, (2011) Inhibition of the formation of advanced glycation end products by thymoquinone. Food Chem 128: 55-61.
25. Lee C, Yim MB, Chock PB, Yim HS, Kang SO, (1998) Oxidation-reduction properties of methylglyoxal-modified protein in relation to free radical generation. J Biol Chem 273: 25272-25278.
26. Rahbar S, Yernini KK, Scott S, Gonzales N, Lalezari I, (1999) Novel inhibitors of advanced glycation end products. Biochem Biophys Res Commun 262: 651-656.
27. Nagaraj RH, Shipanova IN, Faust FM, (1996) Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal. J Biol Chem 271: 19338-19345.
28. Bucciantini M, Giannoni E, Chiti F, Baroni F, Formigli L, et al. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416: 507-511.
29. Schmitt A, Schmitt J, Munch G, Gasic-Milencovic J, (2005) Characterization of advanced glycation endproducts for biochemical studes: side chain modifications and fluorescence characteristics. Anal Biochem 338: 201-215.
30. Mironova R, Niwa T, Handzhiyski Y, Sredovska A, Ivanow I, (2005) Evidence for non-enzymatic glycosyalation of E coli chromosomal DNA. Mol Microbiol 55: 1801-1811.
31. Rahbar S, Nadler JL, (1999) A new rapid method to detect inhibition of Amadori product generated by delta-gluconolactone. Clin Chim Acta 87: 123-130.
32. Metz TO, Alderson NL, Thorpe SR, Baynes JW, (2003) Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: A novel therapy for treatment of diabetic complications. Arch Biochem Biophys 419: 41-49.
33. Marchetti P, (2009) Advanced glycation end products (AGEs) and their receptors (RAGEs) in diabetic vascular disease. Medicographia 31: 257-265.
34. Thornalley PJ, (2003) Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation end products. Arch Biochem Biophys 419: 31-40.
35. Cervantes-Laurean D, Schramm DD, Jacobson EL, Halaweish I, Bruckner GG, et al. (2006) Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites. J Nutr Biochem 17: 531-540.
36. Nagaraj RH, Shipanova IN, Faust FM, (1996) Protein cross-linking by the maillard reaction. J Biol Chem 271: 19338-19345.
37. Kim EJ, Lim KM, Kim KY, Bae ON, Noh JY, et al. (2009) Doxorubicin-induced platelet cytotoxicity: a new contributory factor for doxorubicin-mediated thrombocytopenia. J Thromb and Haemost 7: 1172-1183.
38. Kanazawa I, Yamamoto M, Yamaguchi T, Sugimoto T, (2011) Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 119: 362-365.
39. You WH, Wang P, Li MQ, Zhang Y, Peng YL, et al. (2009) Therapeutic effects of modified Danggui Sini Decoction on plasma level of advanced glycation end products in patients with Wagner grade 0 diabetic foot: a randomized controlled trial. Zhong Xi Yi Jie He Xue Bao 7: 622-628.
40. Kakuta T, Tanaka R, Hyodo T, Suzuki H, Kanai G, et al. (2011) Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients. Am J Kidney Dis 57: 422-431.
41. Nascimento MM, Suliman ME, Murayama Y, Nihi M, Hayashi SY, et al. (2006) Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo controlled study. J Ren Nutr 16: 119-124.
42. Khan MS, Ansari IA, Ahmad S, Akhter F, Hashim A, et al. (2013) Chemotherapeutic potential of Boerhaavia diffusa Linn: A review. J Appl Pharma Sci 3: 133-139.
43. Hashim A, Khan MS, Khan M Sajid, Baig MH, Ahmad S (2013) Antioxidant and α-Amylase Inhibitory Property of Phyllanthus virgatus L.: An In Vitro and Molecular Interaction Study. Biomed Res Int. Available: http://dx.doi.org/10.1155/2013/729393. Accessed 2013 Aug 1.