Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14616-14621

  Gupte, Rebecca ^a,b   Muse, Ginger W ^c   Chinenov, Yurii ^b   Adelman, Karen ^c   Rogatsky, Inez ^a,b  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Inflammation; Initiation and elongation; NELF and P TEFb complex; Transcriptional repression

Indexed keywords

CHEMOKINE; CYCLIN T1; DEXAMETHASONE; DNA BOUND ACTIVATOR PROTEIN 1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; I KAPPA B; LIPOPOLYSACCHARIDE; NUCLEAR RECEPTOR COACTIVATOR 2; RNA POLYMERASE II; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; GRIP1 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEGATIVE ELONGATION FACTOR; NERVE PROTEIN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; IMMUNOBLOTTING; IMMUNOGENETICS; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR OCCUPANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; RNA SYNTHESIS; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NF-KAPPA B; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA POLYMERASE II; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84883357296     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309898110     Document Type: Article

References (41)

1. González-Terán B, et al. (2013) Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. J Clin Invest 123(1):164-178.
2. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140(6):821-832.
3. Ronkina N, et al. (2010) MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochem Pharmacol 80(12):1915-1920.
4. Takeuchi O, Akira S (2010) Pattern recognition receptors and infl ammation. Cell 140(6):805-820.
5. Savitsky D, Tamura T, Yanai H, Taniguchi T (2010) Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 59(4):489-510.
6. Muse GW, et al. (2007) RNA polymerase is poised for activation across the genome. Nat Genet 39(12):1507-1511. (Pubitemid 350191341)
7. Zeitlinger J, et al. (2007) RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet 39(12):1512-1516. (Pubitemid 350191345)
8. Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA (2007) A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130(1):77-88. (Pubitemid 47031323)
9. Narita T, et al. (2003) Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol 23(6):1863-1873. (Pubitemid 36278801)
10. Peterlin BM, Price DH (2006) Controlling the elongation phase of transcription with P-TEFb. Mol Cell 23(3):297-305. (Pubitemid 44128850)
11. Adelman K, et al. (2009) Immediate mediators of the in flammatory response are poised for gene activation through RNA polymerase II stalling. Proc Natl Acad Sci USA 106(43):18207-18212.
12. Gilchrist DA, et al. (2008) NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev 22(14):1921-1933. (Pubitemid 352008640)
13. Hargreaves DC, Horng T, Medzhitov R (2009) Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138(1):129-145.
14. Tracey KJ, et al. (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234(4775):470-474. (Pubitemid 17181429)
15. Spriggs DR, et al. (1988) Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacologic study. J Natl Cancer Inst 80(13):1039-1044.
16. Silverman MN, Sternberg EM (2012) Glucocorticoid regulation of inflammation and its functional correlates: From HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci 1261:55-63.
17. Tsai MJ, O'Malley BW (1994) Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486.
18. Glass CK, Saijo K (2010) Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol 10(5):365-376.
19. Yamamoto KR, Darimont BD, Wagner RL, Iñiguez-Lluhí JA (1998) Building transcriptional regulatory complexes: Signals and surfaces. Cold Spring Harb Symp Quant Biol 63:587-598. (Pubitemid 29282204)
20. Chinenov Y, Gupte R, Rogatsky I (2013) Nuclear receptors in inflammation control: Repression by GR and beyond. Mol Cell Endocrinol, 10.1016/j.mce.2013. 04.006.
21. Chinenov Y, et al. (2012) Role of transcriptional coregulator GRIP1 in the antiinflammatory actions of glucocorticoids. Proc Natl Acad Sci USA 109(29):11776-11781.
22. Ramirez-Carrozzi VR, et al. (2009) A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell 138(1):114-128.
23. Escoubet-Lozach L, et al. (2011) Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet 7(12):e1002401.
24. Heidemann M, Hintermair C, Voß K, Eick D (2013) Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription. Biochim Biophys Acta 1829(1):55-62.
25. Barboric M, Nissen RM, Kanazawa S, Jabrane-Ferrat N, Peterlin BM (2001) NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell 8(2):327-337. (Pubitemid 32831550)
26. Amleh A, et al. (2009) Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS ONE 4(4):e5034.
27. Sun J, et al. (2008) Deregulation of cofactor of BRCA1 expression in breast cancer cells. J Cell Biochem 103(6):1798-1807. (Pubitemid 351501911)
28. Aiyar SE, et al. (2004) Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev 18(17):2134-2146. (Pubitemid 39166630)
29. Narita T, et al. (2007) NELF interacts with CBC and participates in 3′ end processing of replication-dependent histone mRNAs. Mol Cell 26(3):349-365. (Pubitemid 46687102)
30. Sun J, Blair AL, Aiyar SE, Li R (2007) Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing. J Steroid Biochem Mol Biol 107(3-5):131-139. (Pubitemid 47380383)
31. Kininis M, Isaacs GD, Core LJ, Hah N, Kraus WL (2009) Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes. Mol Cell Biol 29(5):1123-1133.
32. Danko CG, et al. (2013) Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells. Mol Cell 50(2):212-222.
33. Ogawa S, et al. (2005) Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122(5):707-721. (Pubitemid 41242636)
34. Nissen RM, Yamamoto KR (2000) The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 14(18):2314-2329.
35. Luecke HF, Yamamoto KR (2005) The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev 19(9):1116-1127. (Pubitemid 40632456)
36. Ramirez-Carrozzi VR, et al. (2006) Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev 20(3):282-296. (Pubitemid 43200283)
37. König H, Ponta H, Rahmsdorf HJ, Herrlich P (1992) Interference between pathway-specific transcription factors: Glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J 11(6):2241-2246.
38. Caldenhoven E, et al. (1995) Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9(4):401-412.
39. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS, Jr. (1995) Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol 15(2):943-953.
40. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5(7):621-628. (Pubitemid 351911867)
41. Gehin M, et al. (2002) The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol 22(16):5923-5937. (Pubitemid 34815840)