Effects of chronic Akt/mTOR inhibition by rapamycin on mechanical overload-induced hypertrophy and myosin heavy chain transition in masseter muscle

Journal of Pharmacological Sciences

Volumn 122, Issue 4, 2013, Pages 278-288

  Umeki, Daisuke ^a   Ohnuki, Yoshiki ^a   Mototani, Yasumasa ^a   Shiozawa, Kouichi ^a   Fujita, Takayuki ^b   Nakamura, Yoshiki ^a   Saeki, Yasutake ^a   Okumura, Satoshi ^a,b  

^a TSURUMI UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Akt mammalian target of rapamycin (mTOR) pathway; Hypertrophy; Masseter muscle; Mechanical stress; Myosin heavy chain

Indexed keywords

CALCINEURIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN HEAVY CHAIN; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FAST MUSCLE FIBER; JAW MOVEMENT; MASSETER MUSCLE; MECHANICAL STRESS; MUSCLE HYPERTROPHY; MUSCLE MASS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SLOW MUSCLE FIBER;

ANIMALS; BIOMECHANICAL PHENOMENA; BITE FORCE; CALCINEURIN; HYPERTROPHY; MAP KINASE SIGNALING SYSTEM; MASSETER MUSCLE; MYOSIN HEAVY CHAINS; ONCOGENE PROTEIN V-AKT; ORGAN SIZE; PHOSPHORYLATION; PROTEIN ISOFORMS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SIROLIMUS; STRESS, MECHANICAL; TOR SERINE-THREONINE KINASES;

EID: 84883329950     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12195FP     Document Type: Article

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