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Volumn 6, Issue , 2013, Pages 1119-1127

Influence of the oncolytic parvovirus H-1, CTLA-4 antibody tremelimumab and cytostatic drugs on the human immune system in a human in vitro model of colorectal cancer cells

Author keywords

Dendritic cells; SW480

Indexed keywords

CYTOSTATIC AGENT; FLUOROURACIL; INTERLEUKIN 4; IRINOTECAN; ONCOLYTIC PARVOVIRUS; OXALIPLATIN; TICILIMUMAB;

EID: 84883281279     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S49371     Document Type: Article
Times cited : (17)

References (53)
  • 1
    • 36348954489 scopus 로고    scopus 로고
    • Immunotherapy and immunoescape in colorectal cancer
    • Mazzolini G, Murillo O, Atorrasagasti C, et al. Immunotherapy and immunoescape in colorectal cancer. World J Gastroenterol. 2007;13(44): 5822-5831.
    • (2007) World J Gastroenterol. , vol.13 , Issue.44 , pp. 5822-5831
    • Mazzolini, G.1    Murillo, O.2    Atorrasagasti, C.3
  • 2
    • 3042844293 scopus 로고    scopus 로고
    • Cancer immunotherapy: A treatment for the masses
    • Blattman JN, Greenberg PD. Cancer immunotherapy: a treatment for the masses. Science. 2004;305(5681):200-205.
    • (2004) Science. , vol.305 , Issue.5681 , pp. 200-205
    • Blattman, J.N.1    Greenberg, P.D.2
  • 3
    • 34548335284 scopus 로고    scopus 로고
    • Cytotoxic effects of the oncolytic herpes simplex virus HSV1716 alone and in combination with cisplatin in head and neck squamous cell carcinoma
    • Mace AT, Harrow SJ, Ganly I, Brown SM. Cytotoxic effects of the oncolytic herpes simplex virus HSV1716 alone and in combination with cisplatin in head and neck squamous cell carcinoma. Acta Otolaryngol. 2007;127(8):880-887.
    • (2007) Acta Otolaryngol. , vol.127 , Issue.8 , pp. 880-887
    • Mace, A.T.1    Harrow, S.J.2    Ganly, I.3    Brown, S.M.4
  • 4
    • 38349079989 scopus 로고    scopus 로고
    • Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene
    • Chalikonda S, Kivlen MH, O'Malley ME, et al. Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene. Cancer Gene Ther. 2008;15(2): 115-125.
    • (2008) Cancer Gene Ther. , vol.15 , Issue.2 , pp. 115-125
    • Chalikonda, S.1    Kivlen, M.H.2    O'Malley, M.E.3
  • 6
    • 0035050285 scopus 로고    scopus 로고
    • Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors
    • Moehler M, Blechacz B, Weiskopf N, et al. Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors. Cancer Gene Ther. 2001;8(3):158-167.
    • (2001) Cancer Gene Ther. , vol.8 , Issue.3 , pp. 158-167
    • Moehler, M.1    Blechacz, B.2    Weiskopf, N.3
  • 7
    • 82955239884 scopus 로고    scopus 로고
    • Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1
    • Moehler M, Sieben M, Roth S, et al. Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1. BMC Cancer. 2011;11:464.
    • (2011) BMC Cancer. , vol.11 , pp. 464
    • Moehler, M.1    Sieben, M.2    Roth, S.3
  • 8
    • 0037942832 scopus 로고    scopus 로고
    • Replicating parvoviruses that target colon cancer cells
    • Malerba M, Daeffler L, Rommelaere J, Iggo RD. Replicating parvoviruses that target colon cancer cells. J Virol. 2003;77(12): 6683-6691.
    • (2003) J Virol. , vol.77 , Issue.12 , pp. 6683-6691
    • Malerba, M.1    Daeffler, L.2    Rommelaere, J.3    Iggo, R.D.4
  • 9
    • 23844451373 scopus 로고    scopus 로고
    • Parvovirus H-1-induced tumor cell death enhances human immune response in vitro via increased phagocytosis, maturation, and cross-presentation by dendritic cells
    • Moehler MH, Zeidler M, Wilsberg V, et al. Parvovirus H-1-induced tumor cell death enhances human immune response in vitro via increased phagocytosis, maturation, and cross-presentation by dendritic cells. Hum Gene Ther. 2005;16(8):996-1005.
    • (2005) Hum Gene Ther. , vol.16 , Issue.8 , pp. 996-1005
    • Moehler, M.H.1    Zeidler, M.2    Wilsberg, V.3
  • 10
    • 9144261696 scopus 로고    scopus 로고
    • Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication
    • van Mierlo GJ, Boonman ZF, Dumortier HM, et al. Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication. J Immunol. 2004;173(11):6753-6759.
    • (2004) J Immunol. , vol.173 , Issue.11 , pp. 6753-6759
    • van Mierlo, G.J.1    Boonman, Z.F.2    Dumortier, H.M.3
  • 11
    • 37349115591 scopus 로고    scopus 로고
    • The 'kiss of death' by dendritic cells to cancer cells
    • Chan CW, Housseau F. The 'kiss of death' by dendritic cells to cancer cells. Cell Death Differ. 2008;15(1):58-69.
    • (2008) Cell Death Differ. , vol.15 , Issue.1 , pp. 58-69
    • Chan, C.W.1    Housseau, F.2
  • 12
    • 79952706673 scopus 로고    scopus 로고
    • CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation
    • Wang XB, Fan ZZ, Anton D, et al. CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation. BMC Immunol. 2011;12:21.
    • (2011) BMC Immunol. , vol.12 , pp. 21
    • Wang, X.B.1    Fan, Z.Z.2    Anton, D.3
  • 13
    • 27144458821 scopus 로고    scopus 로고
    • CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction
    • Contardi E, Palmisano GL, Tazzari PL, et al. CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. Int J Cancer. 2005;117(4):538-550.
    • (2005) Int J Cancer. , vol.117 , Issue.4 , pp. 538-550
    • Contardi, E.1    Palmisano, G.L.2    Tazzari, P.L.3
  • 15
    • 84862882003 scopus 로고    scopus 로고
    • Tumor immunotherapy directed at PD-1
    • Ribas A. Tumor immunotherapy directed at PD-1. N Engl J Med. 2012;366(26):2517-2519.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2517-2519
    • Ribas, A.1
  • 16
    • 34548240159 scopus 로고    scopus 로고
    • Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer
    • Ribas A, Hanson DC, Noe DA, et al. Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer. Oncologist. 2007;12(7):873-883.
    • (2007) Oncologist. , vol.12 , Issue.7 , pp. 873-883
    • Ribas, A.1    Hanson, D.C.2    Noe, D.A.3
  • 17
    • 78649990016 scopus 로고    scopus 로고
    • A more selective costimulatory blockade of the CD28-B7 pathway
    • Poirier N, Blancho G, Vanhove B. A more selective costimulatory blockade of the CD28-B7 pathway. Transpl Int. 2011;24(1):2-11.
    • (2011) Transpl Int. , vol.24 , Issue.1 , pp. 2-11
    • Poirier, N.1    Blancho, G.2    Vanhove, B.3
  • 18
    • 58749114723 scopus 로고    scopus 로고
    • Overcoming immunologic tolerance to melanoma: Targeting CTLA-4 with tremelimumab (CP-675,206)
    • Ribas A. Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with tremelimumab (CP-675,206). Oncologist. 2008; 13 Suppl 4:10-15.
    • (2008) Oncologist. , vol.13 , Issue.SUPPL. 4 , pp. 10-15
    • Ribas, A.1
  • 19
    • 81055127514 scopus 로고    scopus 로고
    • Anti-CTLA4 monoclonal antibodies: The past and the future in clinical application
    • Ascierto PA, Marincola FM, Ribas A. Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application. J Transl Med. 2011;9:196.
    • (2011) J Transl Med. , vol.9 , pp. 196
    • Ascierto, P.A.1    Marincola, F.M.2    Ribas, A.3
  • 20
    • 33646578505 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression
    • Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F. Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology. 2006;118(2):240-249.
    • (2006) Immunology. , vol.118 , Issue.2 , pp. 240-249
    • Oderup, C.1    Cederbom, L.2    Makowska, A.3    Cilio, C.M.4    Ivars, F.5
  • 21
    • 33748608026 scopus 로고    scopus 로고
    • Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells
    • Zhu Q, Liu JY, Yang CM, et al. Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006;18(10):1071-1077.
    • (2006) Eur J Gastroenterol Hepatol. , vol.18 , Issue.10 , pp. 1071-1077
    • Zhu, Q.1    Liu, J.Y.2    Yang, C.M.3
  • 22
    • 0038277131 scopus 로고    scopus 로고
    • Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells
    • Moehler M, Zeidler M, Schede J, et al. Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells. Cancer Gene Ther. 2003;10(6):477-480.
    • (2003) Cancer Gene Ther. , vol.10 , Issue.6 , pp. 477-480
    • Moehler, M.1    Zeidler, M.2    Schede, J.3
  • 23
    • 0029994319 scopus 로고    scopus 로고
    • Interferon-gamma: Biology and role in pathogenesis
    • Billiau A. Interferon-gamma: biology and role in pathogenesis. Adv Immunol. 1996;62:61-130.
    • (1996) Adv Immunol. , vol.62 , pp. 61-130
    • Billiau, A.1
  • 24
  • 25
    • 84875601707 scopus 로고    scopus 로고
    • Activation of the human immune system via toll-like receptors by the oncolytic parvovirus H-1
    • Sieben M, Schäfer P, Dinsart C, Galle PR, Moehler M. Activation of the human immune system via toll-like receptors by the oncolytic parvovirus H-1. Int J Cancer. 2013;132(11):2548-2556.
    • (2013) Int J Cancer. , vol.132 , Issue.11 , pp. 2548-2556
    • Sieben, M.1    Schäfer, P.2    Dinsart, C.3    Galle, P.R.4    Moehler, M.5
  • 26
    • 0035171028 scopus 로고    scopus 로고
    • New perspectives in dendritic cell-based cancer immunotherapy
    • Nencioni A, Brossart P. New perspectives in dendritic cell-based cancer immunotherapy. BioDrugs. 2001;15(10):667-679.
    • (2001) BioDrugs. , vol.15 , Issue.10 , pp. 667-679
    • Nencioni, A.1    Brossart, P.2
  • 29
    • 0034327809 scopus 로고    scopus 로고
    • Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
    • Iida T, Ohno H, Nakaseko C, et al. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J Immunol. 2000;165(9):5062-5068.
    • (2000) J Immunol. , vol.165 , Issue.9 , pp. 5062-5068
    • Iida, T.1    Ohno, H.2    Nakaseko, C.3
  • 30
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011;332(6029):600-603.
    • (2011) Science. , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 31
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint blockade in cancer immunotherapy
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol. 2006;90:297-339.
    • (2006) Adv Immunol. , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 32
    • 27744482874 scopus 로고    scopus 로고
    • Immunoregulation of dendritic cells
    • Wallet MA, Sen P, Tisch R. Immunoregulation of dendritic cells. Clin Med Res. 2005;3(3):166-175.
    • (2005) Clin Med Res. , vol.3 , Issue.3 , pp. 166-175
    • Wallet, M.A.1    Sen, P.2    Tisch, R.3
  • 33
    • 77955292303 scopus 로고    scopus 로고
    • Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
    • Chung KY, Gore I, Fong L, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol. 2010;28(21):3485-3490.
    • (2010) J Clin Oncol. , vol.28 , Issue.21 , pp. 3485-3490
    • Chung, K.Y.1    Gore, I.2    Fong, L.3
  • 34
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-2454.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 35
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455-2465.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 36
    • 79955112364 scopus 로고    scopus 로고
    • Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
    • Schurich A, Khanna P, Lopes AR, et al. Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology. 2011;53(5): 1494-1503.
    • (2011) Hepatology. , vol.53 , Issue.5 , pp. 1494-1503
    • Schurich, A.1    Khanna, P.2    Lopes, A.R.3
  • 37
    • 79960695491 scopus 로고    scopus 로고
    • DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic
    • Yin Y, Wu C, Song J, et al. DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic. PLoS One. 2011;6(7):e22524.
    • (2011) PLoS One. , vol.6 , Issue.7
    • Yin, Y.1    Wu, C.2    Song, J.3
  • 38
    • 84857391377 scopus 로고    scopus 로고
    • Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection
    • Suneetha PV, Pischke S, Schlaphoff V, et al. Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. Hepatology. 2012;55(3):695-708.
    • (2012) Hepatology. , vol.55 , Issue.3 , pp. 695-708
    • Suneetha, P.V.1    Pischke, S.2    Schlaphoff, V.3
  • 39
    • 80053578249 scopus 로고    scopus 로고
    • Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection
    • Raziorrouh B, Ulsenheimer A, Schraut W, et al. Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection. Gastroenterology. 2011;141(4):1422-1431, 1431 e1-6.
    • (2011) Gastroenterology. , vol.141 , Issue.4
    • Raziorrouh, B.1    Ulsenheimer, A.2    Schraut, W.3
  • 40
    • 33845236614 scopus 로고    scopus 로고
    • CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    • Hryniewicz A, Boasso A, Edghill-Smith Y, et al. CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood. 2006;108(12):3834-3842.
    • (2006) Blood. , vol.108 , Issue.12 , pp. 3834-3842
    • Hryniewicz, A.1    Boasso, A.2    Edghill-Smith, Y.3
  • 41
    • 67649268353 scopus 로고    scopus 로고
    • CTLA4 blockade increases Th17 cells in patients with metastatic melanoma
    • von Euw E, Chodon T, Attar N, et al. CTLA4 blockade increases Th17 cells in patients with metastatic melanoma. J Transl Med. 2009;7:35.
    • (2009) J Transl Med. , vol.7 , pp. 35
    • von Euw, E.1    Chodon, T.2    Attar, N.3
  • 42
    • 79961102493 scopus 로고    scopus 로고
    • Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo
    • Suarez N, Alfaro C, Dubrot J, et al. Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo. Int J Cancer. 2011;129(2):374-386.
    • (2011) Int J Cancer. , vol.129 , Issue.2 , pp. 374-386
    • Suarez, N.1    Alfaro, C.2    Dubrot, J.3
  • 43
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev. 2008;222:206-221.
    • (2008) Immunol Rev. , vol.222 , pp. 206-221
    • Katz, J.B.1    Muller, A.J.2    Prendergast, G.C.3
  • 44
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004;75(2):163-189.
    • (2004) J Leukoc Biol. , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 45
    • 33645782015 scopus 로고    scopus 로고
    • TNF-alpha in cancer treatment: Molecular insights, antitumor effects, and clinical utility
    • van Horssen R, Ten Hagen TL, Eggermont AM. TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist. 2006;11(4):397-408.
    • (2006) Oncologist. , vol.11 , Issue.4 , pp. 397-408
    • van Horssen, R.1    Ten Hagen, T.L.2    Eggermont, A.M.3
  • 46
    • 3342927147 scopus 로고    scopus 로고
    • Signaling through death receptors in cancer therapy
    • Fulda S, Debatin KM. Signaling through death receptors in cancer therapy. Curr Opin Pharmacol. 2004;4(4):327-332.
    • (2004) Curr Opin Pharmacol. , vol.4 , Issue.4 , pp. 327-332
    • Fulda, S.1    Debatin, K.M.2
  • 48
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said EA, Dupuy FP, Trautmann L, et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med. 2010;16(4):452-459.
    • (2010) Nat Med. , vol.16 , Issue.4 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3
  • 49
    • 0023726937 scopus 로고
    • Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
    • Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol. 1988;140(12): 4245-4252.
    • (1988) J Immunol. , vol.140 , Issue.12 , pp. 4245-4252
    • Gajewski, T.F.1    Fitch, F.W.2
  • 50
    • 84874633092 scopus 로고    scopus 로고
    • IL-6 production by dendritic cells is dispensable for CD8(+) memory T-cell generation
    • Daudelin JF, Mathieu M, Boulet S, Labrecque N. IL-6 production by dendritic cells is dispensable for CD8(+) memory T-cell generation. Biomed Res Int. 2013;2013:126189.
    • (2013) Biomed Res Int. , vol.2013 , pp. 126189
    • Daudelin, J.F.1    Mathieu, M.2    Boulet, S.3    Labrecque, N.4
  • 51
    • 70349680756 scopus 로고    scopus 로고
    • Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    • Ribas A, Comin-Anduix B, Chmielowski B, et al. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res. 2009;15(19):6267-6276.
    • (2009) Clin Cancer Res. , vol.15 , Issue.19 , pp. 6267-6276
    • Ribas, A.1    Comin-Anduix, B.2    Chmielowski, B.3
  • 52
    • 84875225339 scopus 로고    scopus 로고
    • Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
    • Heo J, Reid T, Ruo L, et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat Med. 2013;19(3):329-336.
    • (2013) Nat Med. , vol.19 , Issue.3 , pp. 329-336
    • Heo, J.1    Reid, T.2    Ruo, L.3
  • 53
    • 84858608281 scopus 로고    scopus 로고
    • Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol
    • Geletneky K, Huesing J, Rommelaere J, et al. Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol. BMC Cancer. 2012;12:99.
    • (2012) BMC Cancer. , vol.12 , pp. 99
    • Geletneky, K.1    Huesing, J.2    Rommelaere, J.3


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