Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 9, 2013, Pages 2233-2239

  Isaacs, Aaron ^a   Willems, Sara M ^a   Bos, Daniel ^b   Dehghan, Abbas ^b   Hofman, Albert ^b   Arfan Ikram, M ^b,c   Uitterlinden, André G ^a,b   Oostra, Ben A ^a   Franco, Oscar H ^b   Witteman, Jacqueline C ^b   Van Duijn, Cornelia M ^a,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Department of Radiology ^*  (United States)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

atherosclerosis; carotid artery plaque; carotid intima media thickness; coronary disease; genetic screening; lipids; myocardial infarction

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC RISK; GENETIC VARIABILITY; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SEX DIFFERENCE;

ATHEROSCLEROSIS; CAROTID ARTERY PLAQUE; CAROTID INTIMA-MEDIA THICKNESS; CORONARY DISEASE; GENETIC SCREENING; LIPIDS; MYOCARDIAL INFARCTION;

ADULT; AGED; ASYMPTOMATIC DISEASES; BIOLOGICAL MARKERS; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY DISEASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; LINEAR MODELS; LIPIDS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NETHERLANDS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; TRIGLYCERIDES;

EID: 84883274125     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.113.301236     Document Type: Article

References (25)

1. World Health Organization. Media centre, Fact Sheets: Cardiovascular diseases (CVDs). http://www.who.int/mediacentre/factsheets/fs317/en/index.html. Accessed August 2012
2. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J 3rd. Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann Intern Med. 1961;55:33-50.
3. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837-1847. (Pubitemid 28213628)
4. Arsenault BJ, Boekholdt SM, Kastelein JJ. Lipid parameters for measuring risk of cardiovascular disease. Nat Rev Cardiol. 2011;8:197-206.
5. Isaacs A, Sayed-Tabatabaei FA, Aulchenko YS, Zillikens MC, Sijbrands EJ, Schut AF, Rutten WP, Pols HA, Witteman JC, Oostra BA, van Duijn CM. Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study. Eur J Epidemiol. 2007;22:99-105. (Pubitemid 46457307)
6. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006;38:218-222. (Pubitemid 43177237)
7. Willer CJ, Sanna S, Jackson AU, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 2008;40:161-169. (Pubitemid 351171403)
8. Kathiresan S, Melander O, Guiducci C, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008;40:189-197. (Pubitemid 351171402)
9. Kathiresan S, Willer CJ, Peloso GM, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009;41:56-65.
10. Aulchenko YS, Ripatti S, Lindqvist I, et al; ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009;41:47-55.
11. Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-713.
12. Fisher RA. The correlation between relatives on the supposition of Mendelian inheritance. Phil Trans R Soc Edinburgh. 1918:399-433.
13. Tsao CW, Preis SR, Peloso GM, Hwang SJ, Kathiresan S, Fox CS, Cupples LA, Hoffmann U, O'Donnell CJ. Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the Framingham Heart Study. J Am Coll Cardiol. 2012;60:2364-2371.
14. Bos D, Ikram MA, Isaacs A, Verhaaren BF, Hofman A, van Duijn CM, Witteman JC, van der Lugt A, Vernooij MW. Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification. Circ Cardiovasc Genet. 2013;6:47-53.
15. Shah S, Casas JP, Gaunt TR, et al. Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J. 2013;34:972-981.
16. Talayero BG, Sacks FM. The role of triglycerides in atherosclerosis. Curr Cardiol Rep. 2011;13:544-552.
17. Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study. Lancet. 2012;380:572-580.
18. Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010;375:1634-1639.
19. Oei HH, Vliegenthart R, Hak AE, Iglesias del Sol A, Hofman A, Oudkerk M, Witteman JC. The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis: the Rotterdam Coronary Calcification Study. J Am Coll Cardiol. 2002;39:1745-1751. (Pubitemid 34595283)
20. Schork NJ, Murray SS, Frazer KA, Topol EJ. Common vs rare allele hypotheses for complex diseases. Curr Opin Genet Dev. 2009;19:212-219.
21. Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012;159:64-79.
22. Schunkert H, Konig IR, Kathiresan S, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333-338.
23. van der Graaf A, Avis HJ, Kusters DM, Vissers MN, Hutten BA, Defesche JC, Huijgen R, Fouchier SW, Wijburg FA, Kastelein JJ, Wiegman A. Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children. Circulation. 2011;123:1167-1173.
24. Watts GF, Juniper A, van Bockxmeer F, Ademi Z, Liew D, O'Leary P. Familial hypercholesterolaemia: a review with emphasis on evidence for treatment, new models of care and health economic evaluations. Int J Evid Based Healthc. 2012;10:211-221.
25. Sanna S, Li B, Mulas A, et al. Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet. 2011;7:e1002198.