Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase

Brain Research

Volumn 1530, Issue , 2013, Pages 44-53

  Danjo, Sonoko ^a,b   Ishihara, Yasuhiro ^c   Watanabe, Masatomo ^b   Nakamura, Yu ^a   Itoh, Kouichi ^b  

^a KAGAWA UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Gd HP DO3A; Generalized convulsive seizures; MRI; Nitric oxide; Pentylenetetrazole

Indexed keywords

GADOLINIUM; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIENCEPHALON; HIPPOCAMPUS; MALE; MOUSE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TONIC CLONIC SEIZURE;

MUS;

GADOLINIUM-1,4,7-TRIS(CARBONYLMETHYL)-10-(2′-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLO-DODECANE; (5S,10R)-(+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5,10-IMINE MALEATE; (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHO NO-3-PENTENOIC ACID ETHYL ESTER; 2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE; AEDS; AMPA; ANTIEPILEPTIC DRUGS; BBB; BLOOD-BRAIN BARRIER; CARBAMAZEPINE; CBF; CBZ; CENTRAL NERVOUS SYSTEM; CEREBRAL BLOOD FLOW; CEREBRAL SMOOTH MUSCLE; CGP39551; CNS; CSM; DETC; DIMETHYL SULFOXIDE; DL-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; DMSO; GABA; GADOLINIUM; GADOLINIUM-ENHANCED T1 WEIGHTED IMAGE; GAMMA-AMINOBUTYRIC ACID; GD; GD-HP-DO3A; GDET1WI; GENERALIZED CONVULSIVE SEIZURES; MAGNETIC RESONANCE IMAGING; MK-801; MRI; N,N-DIETHYLDITHIOCARBAMATE NA; N-METHYL-D-ASPARTATE; NBQX; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NMDA; NNOS; NO; PENTYLENETETRAZOLE; PENTYLENTETRAZOLE; PTZ; SI; SIGNAL INTENSITIES; TBARS; THIOBARBITURIC ACID-REACTIVE SUBSTANCE; VALPROIC ACID; VPA;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENTYLENETETRAZOLE; SEIZURES;

EID: 84883256396     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.06.043     Document Type: Article

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