Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-shugan-san

Experimental and Therapeutic Medicine

Volumn 6, Issue 4, 2013, Pages 913-918

  Xie, Weibin ^a   Qiu, Xinjian ^a   Huang, Xi ^a   Xie, Ying ^a   Wu, Kaige ^a   Wang, Yang ^a   Ji, Hui ^a   He, Juan ^a   Ren, Ping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Chaihu shugan san; Chronic mild stress; Meranzin hydrate; Pharmacokinetics

Indexed keywords

ANTIDEPRESSANT AGENT; CHAIHU SHUGAN SAN; CHINESE DRUG; MERANZIN HYDRATE; SULFAMETHOXAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHINESE MEDICINE; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DRUG BLOOD LEVEL; DRUG STABILITY; FORCED SWIMMING TEST; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMOBILIZATION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; NONHUMAN; OPEN FIELD TEST; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY; WATER DEPRIVATION;

EID: 84883255086     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1229     Document Type: Article

References (14)

1. Lavergne F and Jay TM: A new strategy for antidepressant prescription. Front Neurosci 4: 192, 2010.
2. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ and Monteggia LM: Neurobiology of depression. Neuron 34: 13-25, 2002.
3. Clerbaux T, Detry B, Geubel A, Veriter C, Liistro G, Horsmans Y and Frans A: The oxyhemoglobin dissociation curve in liver cirrhosis. Chest 129: 438-445, 2006.
4. Xiong XY and Wang GX: The holistic treatment for depression. Medicine and Philosophy 28: 66-67, 2007 (In Chinese).
5. Kim SH, Han J, Seog DH, Chung JY, Kim N, Hong PY and Lee SK: Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression. Life Sci 76: 1297-1306, 2005.
6. Fan R, Huang X, Wang Y, et al: Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from Fructus Aurantii found in the traditional chinese medicine Chaihu-Shugan-San: a new approach and its application. Evid Based Complement Alternat Med 2012: 607584, 2012.
7. Hu SH, Huang X, Liang QH, et al: Simultaneously qualitative determination of multiple compounds in Chaihu-Shugan-San (CSS) and in rat intestine by UPLC-PDA. Journal of Medical Research 39: 42-45, 2010 (In Chinese).
8. Qiu XJ, Huang X, Chen ZQ, et al: Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia. J Ethnopharmacol 137: 205-213, 2011.
9. First M, Gil-Ad I, Taler M, Tarasenko I, Novak N and Weizman A: The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. J Mol Neurosci 45: 246-255, 2011.
10. Blokland A, Lieben C and Deutz NE: Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat. J Psychopharmacol 16: 39-49, 2002.
11. Porsolt RD, Bertin A and Jalfre M: Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229: 327-336, 1977.
12. Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A and Henichart JP: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Nat Prod Res 20: 909-916, 2006.
13. Rosselli S, Maggio A, Bellone G, et al: Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Med 73: 116-120, 2007.
14. Huang W, Huang X, Xing Z, et al: Meranzin hydrate induces similar effect to Fructus Aurantii on intestinal motility through activation of H1 histamine receptors. J Gastrointest Surg 15: 87-96, 2011.