Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia

Arthritis and Rheumatism

Volumn 65, Issue 9, 2013, Pages 2430-2440

  Charles, Edgar D ^a   Orloff, Michael I M ^a   Nishiuchi, Eiko ^a   Marukian, Svetlana ^a   Rice, Charles M ^a   Dustin, Lynn B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; PROTEIN A; RHEUMATOID FACTOR;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; CRYOGLOBULINEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GERMLINE MICRONUCLEUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SOMATIC HYPERMUTATION;

ADULT; AGED; B-LYMPHOCYTES; CRYOGLOBULINEMIA; FEMALE; HEPACIVIRUS; HUMANS; MIDDLE AGED; RHEUMATOID FACTOR; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84883253247     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38041     Document Type: Article

References (50)

1. Shepard CW, Finelli L, Alter MJ,. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005; 5: 558-67.
2. Galossi A, Guarisco R, Bellis L, Puoti C,. Extrahepatic manifestations of chronic HCV infection. J Gastrointestin Liver Dis 2007; 16: 65-73.
3. Agnello V, Chung RT, Kaplan LM,. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992; 327: 1490-5.
4. Charles ED, Dustin LB,. Hepatitis C virus-induced cryoglobulinemia. Kidney Int 2009; 76: 818-24.
5. + B cells in HCV-associated mixed cryoglobulinemia. Blood 2008; 111: 1344-56.
6. Sansonno D. F,., Dammacco F,. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis 2005; 5: 227-36.
7. Giordano TP, Henderson L, Landgren O, Chiao EY, Kramer JR, El-Serag H, et al. Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus. JAMA 2007; 297: 2010-7.
8. Hermine O, Lefrere F, Bronowicki JP, Mariette X, Jondeau K, Eclache-Saudreau V, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Engl J Med 2002; 347: 89-94.
9. L kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 1998; 91: 2433-42.
10. Carbonari M, Caprini E, Tedesco T, Mazzetta F, Tocco V, Casato M, et al. Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69-expressing memory B cells in type II cryoglobulinemia: a model of infection-driven lymphomagenesis. J Immunol 2005; 174: 6532-9.
11. Knight GB, Agnello V, Bonagura V, Barnes JL, Panka DJ, Zhang QX,. Human rheumatoid factor cross-idiotypes. IV. Studies on WA XId-positive IgM without rheumatoid factor activity provide evidence that the WA XId is not unique to rheumatoid factors and is distinct from the 17.109 and G6 XIds. J Exp Med 1993; 178: 1903-11.
12. Bende RJ, Aarts WM, Riedl RG, de Jong D, Pals ST, van Noesel CJ,. Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J Exp Med 2005; 201: 1229-41.
13. Kipps TJ, Fong S, Tomhave E, Chen PP, Goldfien RD, Carson DA,. High-frequency expression of a conserved κ light-chain variable-region gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 1987; 84: 2916-20.
14. Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson DA,. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 1989; 86: 5913-7.
15. Forconi F, Potter KN, Wheatley I, Darzentas N, Sozzi E, Stamatopoulos K, et al. The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood 2010; 115: 71-7.
16. Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, et al. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature 2010; 467: 591-5.
17. + clonal peripheral B cells. J Immunol Methods 2011; 363: 210-20.
18. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC,. Predominant autoantibody production by early human B cell precursors. Science 2003; 301: 1374-7.
19. Artandi E, Canfield SM, Tao MH, Calame KL, Morrison SL, Bonagura VR,. Molecular analysis of IgM rheumatoid factor binding to chimeric IgG. J Immunol 1991; 146: 603-10.
20. Artandi SE, Calame KL, Morrison SL, Bonagura VR,. Monoclonal IgM rheumatoid factors bind IgG at a discontinuous epitope comprised of amino acid loops from heavy-chain constant-region domains 2 and 3. Proc Natl Acad Sci U S A 1992; 89: 94-8.
21. Mageed RA, Carson DA, Jefferis R,. Immunogenic and antigenic epitopes of immunoglobulins. XXIII. Idiotypy and molecular specificity of human rheumatoid factors: analysis of cross-reactive idiotype of rheumatoid factor paraproteins from the Wa idiotype group in relation to their IgG subclass specificity. Scand J Immunol 1988; 28: 233-40.
22. Graille M, Stura EA, Corper AL, Sutton BJ, Taussig MJ, Charbonnier JB, et al. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci U S A 2000; 97: 5399-404.
23. Marasca R, Vaccari P, Luppi M, Zucchini P, Castelli I, Barozzi P, et al. Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma. Am J Pathol 2001; 159: 253-61.
24. Bahler DW, Miklos JA, Swerdlow SH,. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood 1997; 89: 3335-44.
25. Kunkel HG, Agnello V, Joslin FG, Winchester RJ, Capra JD,. Cross-idiotypic specificity among monoclonal IgM proteins with anti-γ-globulin activity. J Exp Med 1973; 137: 331-42.
26. Agnello V, Arbetter A, Ibanez de Kasep G, Powell R, Tan EM, Joslin F,. Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype. J Exp Med 1980; 151: 1514-27.
27. Radoux V, Chen PP, Sorge JA, Carson DA,. A conserved human germline Vκ gene directly encodes rheumatoid factor light chains. J Exp Med 1986; 164: 2119-24.
28. Mageed RA, Dearlove M, Goodall DM, Jefferis R,. Immunogenic and antigenic epitopes of immunoglobulins. XVII. Monoclonal antibodies reactive with common and restricted idiotopes to the heavy chain of human rheumatoid factors. Rheumatol Int 1986; 6: 179-83.
29. Pascual V, Victor K, Randen I, Thompson K, Steinitz M, Forre O, et al. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3 [published erratum appears in Scand J Immunol 1994;40:125]. Scand J Immunol 1992; 36: 349-62.
30. Natvig JB, Randen I, Thompson K, Forre O, Mageed RA, Jefferis R, et al. Probing of the rheumatoid factor (RF) V gene repertoire in rheumatoid arthritis (RA) by hybridoma clones. Clin Exp Rheumatol 1990; 8 Suppl 5: 75-80.
31. Carayannopoulos MO, Potter KN, Li Y, Natvig JB, Capra JD,. Evidence that human immunoglobulin M rheumatoid factors can be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc than their germline counterparts. Scand J Immunol 2000; 51: 327-36.
32. Pascual V, Randen I, Thompson K, Sioud M, Forre O, Natvig J, et al. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis: further evidence that some autoantibodies are unmutated copies of germ line genes [published erratum appears in J Clin Invest 1994;94:466]. J Clin Invest 1990; 86: 1320-8.
33. Martin T, Crouzier R, Weber JC, Kipps TJ, Pasquali JL,. Structure-function studies on a polyreactive (natural) autoantibody: polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J Immunol 1994; 152: 5988-96.
34. Agnello V, Barnes JL,. Human rheumatoid factor crossidiotypes. I. WA and BLA are heat-labile conformational antigens requiring both heavy and light chains. J Exp Med 1986; 164: 1809-14.
35. Corper AL, Sohi MK, Bonagura VR, Steinitz M, Jefferis R, Feinstein A, et al. Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction. Nat Struct Biol 1997; 4: 374-81.
36. Martin T, Weber JC, Levallois H, Labouret N, Soley A, Koenig S, et al. Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. Arthritis Rheum 2000; 43: 908-16.
37. H1 associated cross reactive idiotype expression in patients with Lyme arthritis and neuroborreliosis. Ann Rheum Dis 1999; 58: 757-61.
38. Herve M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005; 115: 1636-43.
39. Steininger C, Widhopf GF II, Ghia EM, Morello CS, Vanura K, Sanders R, et al. Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen. Blood 2012; 119: 2293-301.
40. Pos W, Luken BM, Kremer Hovinga JA, Turenhout EA, Scheiflinger F, Dong JF, et al. VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2009; 7: 421-8.
41. Cheng J, Torkamani A, Grover RK, Jones TM, Ruiz DI, Schork NJ, et al. Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal. Proc Natl Acad Sci U S A 2011; 108: 5560-5.
42. Wrammert J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection [published erratum appears in J Exp Med 2011;208:411]. J Exp Med 2011; 208: 181-93.
43. Dennison SM, Anasti K, Scearce RM, Sutherland L, Parks R, Xia SM, et al. Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. J Virol 2011; 85: 1340-7.
44. Haynes BF, Fleming J, St Clair EW, Katinger H, Stiegler G, Kunert R, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 2005; 308: 1906-8.
45. Craig VJ, Arnold I, Gerke C, Huynh MQ, Wundisch T, Neubauer A, et al. Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins. Blood 2010; 115: 581-91.
46. Winkler TH, Fehr H, Kalden JR,. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur J Immunol 1992; 22: 1719-28.
47. Guo W, Smith D, Aviszus K, Detanico T, Heiser RA, Wysocki LJ,. Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity. J Exp Med 2010; 207: 2225-37.
48. h repertoire differences between resolving and chronically evolving hepatitis C virus infections. PLoS One 2011; 6: e25606.
49. Roosnek E, Lanzavecchia A,. Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells. J Exp Med 1991; 173: 487-9.
50. Notkins AL,. Infectious virus-antibody complexes: interaction with anti-immunoglobulins, complement, and rheumatoid factor. J Exp Med 1971; 134: 41-51.