Extra-esophageal manifestations of gastroesophageal reflux disease: Diagnosis and treatment

Drugs

Volumn 73, Issue 12, 2013, Pages 1281-1295

  Hom, Christopher ^a   Vaezi, Michael F ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ESOMEPRAZOLE; GABAPENTIN; LANSOPRAZOLE; OMEPRAZOLE; PEPSIN A; PLACEBO; PREGABALIN; RANITIDINE; SALBUTAMOL;

ASTHMA; CHRONIC COUGH; DRUG MEGADOSE; ENDOSCOPY; ESOPHAGEAL PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HOARSENESS; HUMAN; IMPEDANCE; LARYNGITIS; LARYNGOPHARYNGEAL REFLUX; LARYNGOSCOPY; LUNG FUNCTION; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); PATHOPHYSIOLOGY; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SENSITIVITY AND SPECIFICITY; STOMACH FUNDOPLICATION; SYSTEMATIC REVIEW (TOPIC); TREATMENT DURATION; TREATMENT RESPONSE;

ASTHMA; COUGH; DIAGNOSIS, DIFFERENTIAL; ENDOSCOPY; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; LARYNGITIS; PROTON PUMP INHIBITORS; SEVERITY OF ILLNESS INDEX; TOOTH EROSION;

EID: 84883238532     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0101-8     Document Type: Review

References (129)

1. Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900-20 (quiz 1943).
2. Stanghellini V. Relationship between upper gastrointestinal symptoms and lifestyle, psychosocial factors and comorbidity in the general population: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl. 1999;231:29-37.
3. Dent J, El-Serag HB, Wallander MA, et al. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005;54:710-7.
4. Bor S, Mandiracioglu A, Kitapcioglu G, et al. Gastroesophageal reflux disease in a low-income region in Turkey. Am J Gastroenterol. 2005;100:759-65.
5. Berstad T. Gastro-oesophageal reflux and chronic respiratory disease in infants and children: surgical treatment. Scand J Gastroenterol Suppl. 1995;211:26-8.
6. Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2003;18:605-13.
7. Napierkowski J, Wong RK. Extraesophageal manifestations of GERD. Am J Med Sci. 2003;326:285-99.
8. Shaw GY. Application of ambulatory 24-hour multiprobe pH monitoring in the presence of extraesophageal manifestations of gastroesophageal reflux. Ann Otol Rhinol Laryngol Suppl. 2000;184:15-7.
9. Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900-20 (quiz 1943).
10. Fenter TC, Naslund MJ, Shah MB, et al. The cost of treating the 10 most prevalent diseases in men 50 years of age or older. Am J Manag Care. 2006;12:S90-8.
11. Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500-11.
12. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009;136:376-86.
13. Francis DO, Rymer JA, Slaughter JC, Choksi Y, Jiramongkolchai P, Ogbeide E, et al. High economic burden of caring for patients with suspected extraesophageal reflux. Am J Gastroenterol. 2013 Jun;108(6):905-11
14. Field SK, Evans JA, Price LM. The effects of acid perfusion of the esophagus on ventilation and respiratory sensation. Am J Respir Crit Care Med. 1998;157:1058-62.
15. Ing AJ, Ngu MC, Breslin AB. Pathogenesis of chronic persistent cough associated with gastroesophageal reflux. Am J Respir Crit Care Med. 1994;149:160-7.
16. Adhami T, Goldblum JR, Richter JE, et al. The role of gastric and duodenal agents in laryngeal injury: an experimental canine model. Am J Gastroenterol. 2004;99:2098-106.
17. Tuchman DN, Boyle JT, Pack AI, et al. Comparison of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology. 1984;87:872-81.
18. Tokayer AZ. Gastroesophageal reflux disease and chronic cough. Lung. 2008;186(Suppl 1):S29-34.
19. Shaker R. Protective mechanisms against supraesophageal GERD. J Clin Gastroenterol. 2000;30:S3-8.
20. Jadcherla SR, Gupta A, Coley BD, et al. Esophago-glottal closure reflex in human infants: a novel reflex elicited with concurrent manometry and ultrasonography. Am J Gastroenterol. 2007;102:2286-93.
21. Jaspersen D. Extra-esophageal disorders in gastroesophageal reflux disease. Dig Dis. 2004;22:115-9.
22. Malagelada JR. Review article: supra-oesophageal manifestations of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2004;19(Suppl 1):43-8.
23. DeVault KR. Extraesophageal symptoms of GERD. Cleve Clin J Med. 2003;70(Suppl 5):S20-32.
24. Paterson WG. Extraesophageal complications of gastroesophageal reflux disease. Can J Gastroenterol. 1997;11(Suppl B):45B-50B.
25. Paterson WG. Extraesophageal manifestations of reflux disease: myths and reality. Chest Surg Clin N Am. 2001;11:523-38.
26. Vaezi MF. Chronic cough and gastroesophageal reflux disease: how do we establish a causal link? Chest. 2013;143:587-9.
27. Wright RA, Miller SA, Corsello BF. Acid-induced esophagobronchial-cardiac reflexes in humans. Gastroenterology. 1990;99:71-3.
28. Vaezi MF, Hicks DM, Abelson TI, et al. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol. 2003;1:333-44.
29. Hanson DG, Jiang JJ. Diagnosis and management of chronic laryngitis associated with reflux. Am J Med. 2000;108(Suppl 4a):112S-119S.
30. Poe RH, Kallay MC. Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment. Chest. 2003;123:679-84.
31. Irwin RS. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. Chest. 2006;129:80S-94S.
32. Kahrilas PJ, Lee TJ. Pathophysiology of gastroesophageal reflux disease. Thorac Surg Clin. 2005;15:323-33.
33. Chang AB, Lasserson TJ, Gaffney J, et al. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev. 2005;(2):CD004823.
34. Abou-Ismail A, Vaezi MF. Evaluation of patients with suspected laryngopharyngeal reflux: a practical approach. Curr Gastroenterol Rep. 2011;13:213-8.
35. Vaezi MF. Therapy insight: gastroesophageal reflux disease and laryngopharyngeal reflux. Nat Clin Pract Gastroenterol Hepatol. 2005;2:595-603.
36. Locke GR 3rd, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448-56.
37. Agreus L, Svardsudd K, Talley NJ, et al. Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based study. Am J Gastroenterol. 2001;96:2905-14.
38. Wo JM, Grist WJ, Gussack G, et al. Empiric trial of high-dose omeprazole in patients with posterior laryngitis: a prospective study. Am J Gastroenterol. 1997;92:2160-5.
39. Vaezi MF. Laryngitis and gastroesophageal reflux disease: increasing prevalence or poor diagnostic tests? Am J Gastroenterol. 2004;99:786-8.
40. Metz DC, Childs ML, Ruiz C, et al. Pilot study of the oral omeprazole test for reflux laryngitis. Otolaryngol Head Neck Surg. 1997;116:41-6.
41. Diamond L. Laryngopharyngeal reflux - it's not GERD. JAAPA. 2005;18:50-3.
42. Samuels TL, Johnston N. Pepsin as a causal agent of inflammation during nonacidic reflux. Otolaryngol Head Neck Surg. 2009;141:559-63.
43. Johnston N, Dettmar PW, Bishwokarma B, et al. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope. 2007;117:1036-9.
44. Wood JM, Hussey DJ, Woods CM, et al. Biomarkers and laryngopharyngeal reflux. J Laryngol Otol. 2011;125:1218-24.
45. Johnston N, Wells CW, Blumin JH, et al. Receptor-mediated uptake of pepsin by laryngeal epithelial cells. Ann Otol Rhinol Laryngol. 2007;116:934-8.
46. Bardhan KD, Strugala V, Dettmar PW. Reflux revisited: advancing the role of pepsin. Int J Otolaryngol. 2012;2012:646901.
47. Vaezi MF, Slaughter JC, Smith BS, et al. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment Pharmacol Ther. 2010;32:916-24.
48. Kendall KA. Controversies in the diagnosis and management of laryngopharyngeal reflux disease. Curr Opin Otolaryngol Head Neck Surg. 2006;14:113-5.
49. Hicks DM, Ours TM, Abelson TI, et al. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice. 2002;16:564-79.
50. Milstein CF, Charbel S, Hicks DM, et al. Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope). Laryngoscope. 2005;115:2256-61.
51. Vavricka SR, Storck CA, Wildi SM, et al. Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol. 2007;102:716-22.
52. Richter JE. Typical and atypical presentations of gastroesophageal reflux disease. The role of esophageal testing in diagnosis and management. Gastroenterol Clin North Am. 1996;25:75-102.
53. Vaezi MF. Extraesophageal manifestations of gastroesophageal reflux disease. Clin Cornerstone. 2003;5:32-8 (discussion 39-40).
54. Joniau S, Bradshaw A, Esterman A, et al. Reflux and laryngitis: a systematic review. Otolaryngol Head Neck Surg. 2007;136:686-92.
55. Johnson DA. Medical therapy of reflux laryngitis. J Clin Gastroenterol. 2008;42:589-93.
56. Tutuian R, Castell DO. Use of multichannel intraluminal impedance to document proximal esophageal and pharyngeal nonacidic reflux episodes. Am J Med. 2003;115(Suppl 3A):119S-123S.
57. Vaezi MF, Schroeder PL, Richter JE. Reproducibility of proximal probe pH parameters in 24-hour ambulatory esophageal pH monitoring. Am J Gastroenterol. 1997;92:825-9.
58. Carroll TL, Fedore LW, Aldahlawi MM. pH impedance and high-resolution manometry in laryngopharyngeal reflux disease high-dose proton pump inhibitor failures. Laryngoscope. 2012;122:2473-81.
59. Mainie I, Tutuian R, Agrawal A, et al. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg. 2006;93:1483-7.
60. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55:1398-402.
61. Vaezi MF, Hicks DM, Ours TM, et al. ENT manifestation of GERD: a large prospective study assessing treatment outcome and predictors of response [abstract]. Gastroenterology. 2001;120:A636.
62. Vaezi MF. Laryngitis: from the gastroenterologist's point of view. In: Vaezi MF, editor. Extraesophageal reflux. San Diego: Plural Publishing, Inc.; 2009. p. 37-47.
63. Pritchett JM, Aslam M, Slaughter JC, et al. Efficacy of esophageal impedance/pH monitoring in patients with refractory gastroesophageal reflux disease, on and off therapy. Clin Gastroenterol Hepatol. 2009;7:743-8.
64. Fletcher KC, Goutte M, Slaughter JC, Garrett CG, Vaezi MF. Significance and degree of reflux in patients with primary extraesophageal symptoms. Laryngoscope. 2011;121:2561-5.
65. Wiener GJ, Tsukashima R, Kelly C, et al. Oropharyngeal pH monitoring for the detection of liquid and aerosolized supraesophageal gastric reflux. J Voice. 2009;23:498-504.
66. Yuksel ES SJ, Mukhtar N, Ochieng M, Sun G, Goutte M, Garrett GC, Vaezi MF. An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis. Neurogastroenterol Motil. 2013 May;25(5):e315-23.
67. Sun G, Muddana S, Slaughter JC, et al. A new pH catheter for laryngopharyngeal reflux: normal values. Laryngoscope. 2009;119:1639-43.
68. Wiener GJ, Tsukashima R, Kelly C, et al. Oropharyngeal pH monitoring for the detection of liquid and aerosolized supraesophageal gastric reflux. J Voice. 2009;23:498-504.
69. Potluri S, Friedenberg F, Parkman HP, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci. 2003;48:1813-7.
70. Piper DW, Fenton BH. pH stability and activity curves of pepsin with special reference to their clinical importance. Gut. 1965;6:506-8.
71. Ozmen S, Yucel OT, Sinici I, et al. Nasal pepsin assay and pH monitoring in chronic rhinosinusitis. Laryngoscope. 2008;118:890-4.
72. Printza A, Speletas M, Triaridis S, et al. Is pepsin detected in the saliva of patients who experience pharyngeal reflux? Hippokratia. 2007;11:145-9.
73. Kim TH, Lee KJ, Yeo M, et al. Pepsin detection in the sputum/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms. Digestion. 2008;77:201-6.
74. Strugala V, McGlashan JA, Watson MG, Morice AH, Granier B, Dettmar PW. Detection of pepsin using a non-invasive lateral flow test for the diagnosis of extra-esophageal reflux - results of a pilot study [abstract]. Gut. 2007;56:A212.
75. Saritas Yuksel E, Hong SK, Strugala V, Slaughter JC, Goutte M, Garrett CG, et al. Rapid salivary pepsin test: blinded assessment of test performance in GERD. Laryngoscope. 2012;122:1312-6.
76. Park W, Hicks DM, Khandwala F, et al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope. 2005;115:1230-8.
77. Williams RB, Szczesniak MM, Maclean JC, et al. Predictors of outcome in an open label, therapeutic trial of high-dose omeprazole in laryngitis. Am J Gastroenterol. 2004;99:777-85.
78. Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope. 2006;116:254-60.
79. Qadeer MA, Phillips CO, Lopez AR, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2006;101:2646-54.
80. Francis DO, Goutte M, Slaughter JC, et al. Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux. Laryngoscope. 2011;121:1902-9.
81. Swoger J, Ponsky J, Hicks DM, et al. Surgical fundoplication in laryngopharyngeal reflux unresponsive to aggressive acid suppression: a controlled study. Clin Gastroenterol Hepatol. 2006;4:433-41.
82. Ours TM, Kavuru MS, Schilz RJ, et al. A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol. 1999;94:3131-8.
83. Baldi F, Cappiello R, Cavoli C, et al. Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough: a comparison between two different daily doses of lansoprazole. World J Gastroenterol. 2006;12:82-8.
84. Xiao Y, Carson D, Boris L, et al. The acoustic cough monitoring and manometric profile of cough and throat clearing. Dis Esophagus. 2013 Feb 26. doi: 10.1111/dote.12038. [Epub ahead of print].
85. Irwin RS, Corrao WM, Pratter MR. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis. 1981;123:413-7.
86. Ludviksdottir D, Bjornsson E, Janson C, et al. Habitual coughing and its associations with asthma, anxiety, and gastroesophageal reflux. Chest. 1996;109:1262-8.
87. Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest. 2002;121:158-63.
88. el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113:755-60.
89. Poelmans J, Tack J. Extraoesophageal manifestations of gastro-oesophageal reflux. Gut. 2005;54:1492-9.
90. Alhabib KF, Vedal S, Champion P, et al. The utility of ambulatory pH monitoring in patients presenting with chronic cough and asthma. Can J Gastroenterol. 2007;21:159-63.
91. Sifrim D, Dupont L, Blondeau K, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut. 2005;54:449-54.
92. Irwin RS, Corrao WM, Pratter MR. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful response to specific therapy. Am Rev Respir Dis. 1981;123(4 Pt 1):413-7.
93. Kahrilas PJ, Howden CW, Hughes N, Molloy-Bland M. Response of chronic cough to acid suppressive therapy in patients with gastroesophageal reflux disease. Chest. 2013;143:605-12.
94. Everett CF, Morice AH. Clinical history in gastroesophageal cough. Respir Med. 2007;101:345-8.
95. Laukka MA, Cameron AJ, Schei AJ. Gastroesophageal reflux and chronic cough: which comes first? J Clin Gastroenterol. 1994;19:100-4.
96. Lacy BE, Weiser K, Chertoff J, et al. The diagnosis of gastroesophageal reflux disease. Am J Med. 2010;123:583-92.
97. Kahrilas PJ, Sifrim D. High-resolution manometry and impedance-pH/ manometry: valuable tools in clinical and investigational esophagology. Gastroenterology. 2008;135:756-69.
98. Sifrim D, Holloway R, Silny J, et al. Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings. Gastroenterology. 2001;120:1588-98.
99. Bredenoord AJ, Weusten BL, Timmer R, et al. Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol. 2005;100:265-9.
100. Slaughter JC, Goutte M, Rymer JA, et al. Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2011;9:868-74.
101. Paterson WG, Murat BW. Combined ambulatory esophageal manometry and dual-probe pH-metry in evaluation of patients with chronic unexplained cough. Dig Dis Sci. 1994;39:1117-25.
102. Kavitt RT, Higginbotham T, Slaughter JC, et al. Symptom reports are not reliable during ambulatory reflux monitoring. Am J Gastroenterol. 2012;107:1826-32.
103. Smith JA, Decalmer S, Kelsall A, et al. Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. Gastroenterology. 2010;139:754-62.
104. Faruqi S, Molyneux ID, Fathi H, et al. Chronic cough and esomeprazole: a double-blind placebo-controlled parallel study. Respirology. 2011;16:1150-6.
105. Shaheen NJ, Crockett SD, Bright SD, et al. Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33:225-34.
106. Bastian RW, Vaidya AM, Delsupehe KG. Sensory neuropathic cough: a common and treatable cause of chronic cough. Otolaryngol Head Neck Surg. 2006;135:17-21.
107. O'Connell F, Thomas VE, Pride NB, et al. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am J Respir Crit Care Med. 1994;150:374-80.
108. Lee B, Woo P. Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Ann Otol Rhinol Laryngol. 2005;114:253-7.
109. Mintz S, Lee JK. Gabapentin in the treatment of intractable idiopathic chronic cough: case reports. Am J Med. 2006;119:e13-5.
110. Halum SL, Sycamore DL, McRae BR. A new treatment option for laryngeal sensory neuropathy. Laryngoscope. 2009;119:1844-7.
111. Harding SM, Guzzo MR, Richter JE. 24-h esophageal pH testing in asthmatics: respiratory symptom correlation with esophageal acid events. Chest. 1999;115:654-9.
112. Sontag SJ, O'Connell S, Khandelwal S, et al. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology. 1990;99:613-20.
113. Harding SM, Guzzo MR, Richter JE. The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. Am J Respir Crit Care Med. 2000;162:34-9.
114. Thomas JW. National Heart, Lung, and Blood Institute resources and programs for cell-based therapies. Circ Res. 2007;101:1-6.
115. Parsons JP, Mastronarde JG. Gastroesophageal reflux disease and asthma. Curr Opin Pulm Med. 2010;16:60-3.
116. Choy D, Leung R. Gastro-oesophageal reflux disease and asthma. Respirology. 1997;2:163-8.
117. Zerbib F, Guisset O, Lamouliatte H, et al. Effects of bronchial obstruction on lower esophageal sphincter motility and gastroesophageal reflux in patients with asthma. Am J Respir Crit Care Med. 2002;166:1206-11.
118. Leggett JL, Johnston BT, Mills M, et al. Prevalence of gastroesophageal reflux in difficult asthma: relationship to asthma outcome. Chest. 2005;127:1227-31.
119. Havemann BD, Henderson CA, El-Serag HB. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut. 2007;56:1654-64.
120. Kiljander TO, Salomaa ER, Hietanen EK, et al. Gastroesophageal reflux in asthmatics: a double-blind, placebo-controlled crossover study with omeprazole. Chest. 1999;116:1257-64.
121. Meier JH, McNally PR, Punja M, et al. Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind, placebo-controlled crossover study. Dig Dis Sci. 1994;39:2127-33.
122. Leggett JJ, Johnston BT, Mills M, et al. Prevalence of gastroesophageal reflux in difficult asthma: relationship to asthma outcome. Chest. 2005;127:1227-31.
123. Harding SM, Richter JE, Guzzo MR, et al. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med. 1996;100:395-405.
124. Littner MR, Leung FW, Ballard ED 2nd, et al. Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms. Chest. 2005;128:1128-35.
125. Kiljander TO, Harding SM, Field SK, et al. Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2006;173:1091-7.
126. Sontag SJ, O'Connell S, Khandelwal S, et al. Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies. Am J Gastroenterol. 2003;98:987-99.
127. Mastronarde JG, Anthonisen NR, Castro M, et al. Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med. 2009;360:1487-99.
128. Holbrook JT, Wise RA, Gold BD, et al. Lansoprazole for children with poorly controlled asthma a randomized controlled trial. JAMA. 2012;307:373-81.
129. Gibson PG, Powell H, Coughlan J, et al. Limited (information only) patient education programs for adults with asthma. Cochrane Database Syst Rev. 2002;(2):CD001005.