High-Resolution Manometry and Impedance-pH/Manometry: Valuable Tools in Clinical and Investigational Esophagology

Gastroenterology

Volumn 135, Issue 3, 2008, Pages 756-769

  Kahrilas, Peter J ^a   Sifrim, Daniel ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL ASSESSMENT TOOL; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; ESOPHAGUS; ESOPHAGUS ACHALASIA; ESOPHAGUS FUNCTION; ESOPHAGUS MOTILITY; ESOPHAGUS OBSTRUCTION; ESOPHAGUS PRESSURE; ESOPHAGUS SPASM; GASTROENTEROLOGY; GASTROESOPHAGEAL REFLUX; HIGH RESOLUTION MANOMETRY; HUMAN; IMPEDANCE PH MANOMETRY; INTESTINE CONTRACTION; INTESTINE PRESSURE; LOWER ESOPHAGUS SPHINCTER; MANOMETRY; METHODOLOGY; MONITORING; MOTOR DYSFUNCTION; PH; PRIORITY JOURNAL; REVIEW; SPHINCTER; TOPOGRAPHY;

EID: 51249121578     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.05.048     Document Type: Review

References (112)

1. Nayar D.S., Khandwala F., Achkar E., et al. Esophageal manometry: assessment of interpreter consistency. Clin Gastroenterol Hepatol 3 (2005) 218-224
2. Kahrilas P.J., Clouse R.E., and Hogan W.J. American Gastroenterological Association technical review on the clinical use of esophageal manometry. Gastroenterology 107 (1994) 1865-1884
3. Pandolfino J.E., and Kahrilas P.J. AGA technical review on the clinical use of esophageal manometry. Gastroenterology 128 (2005) 209-224
4. Clouse R.E., and Staiano A. Topography of the esophageal peristaltic pressure wave. Am J Physiol 261 (1991) G677-G684
5. Clouse R.E., Staiano A., Alrakawi A., et al. Application of topographical methods to clinical esophageal manometry. Am J Gastroenterol 95 (2000) 2720-2730
6. Pandolfino J.E., Zhang Q., Ghosh S.K., et al. tLESRs and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry. Gastroenterology 131 (2006) 1725-1733
7. Ghosh S.K., Pandolfino J.E., Zhang Q., et al. Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol (Gastrointest Liver Physiol) 290 (2006) G988-G997
8. Pandolfino J.E., Ghosh S.K., Zhang Q., et al. Quantifying EGJ Morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol 290 (2006) G1033-G1040
9. Ghosh S.K., Pandolfino J.E., Zhang Q., et al. Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry. Am J Physiol 291 (2006) G525-G531
10. Ghosh S.K., Pandolfino J.E., Rice J., et al. Impaired deglutitive EGJ relaxation in clinical esophageal manometry: a quantitative analysis of 400 patients and 75 controls. Am J Physiol 293 (2007) G878-G885
11. Pandolfino J.E., Ghosh S.K., Rice J., et al. Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls. Am J Gastroenterol 103 (2008) 27-37
12. Pandolfino J.E., El-Serag H.B., Zhang Q., et al. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 130 (2006) 639-649
13. Massey B.T., Dodds W.J., Hogan W.J., et al. Abnormal esophageal motility. An analysis of concurrent radiographic and manometric findings. Gastroenterology 101 (1991) 344-354
14. Ghosh S.K., Kahrilas P.J., Lodhia N., et al. Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics. Am J Physiol 293 (2008) G1023-G1028
15. Pandolfino J.E., Ghosh S.K., Lodhia N., et al. Utilizing intraluminal pressure gradients to predict esophageal clearance: a validation study. Am J Gastroenterol 103 (2008) 27-37
16. Pandolfino J.E., Kim H., Ghosh S.K., et al. High resolution manometry of the EGJ: and analysis of crural diaphragm function in GERD. Am J Gastroenterol 102 (2007) 1056-1063
17. Bredenoord A.J., Weusten B.L.A.M., Timmer R., et al. Intermittent spatial separation of diaphragm and lower esophageal sphincter favors acidic and weakly acidic reflux. Gastroenterology 130 (2006) 334-340
18. Scheffer R.C.H., Gooszen H.G., Hebbard G.S., et al. The role of transphincteric pressure and proximal gastric volume in acid reflux before and after fundoplication. Gastroenterology 129 (2005) 1900-1909
19. Ghosh S.K., Janiak P., Schwizer W., et al. Physiology of the esophageal pressure transition zone: separate contraction waves above and below. Am J Physiol 290 (2006) G568-G576
20. Fox M., Hebbard G.H., Janiak P., et al. High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol Motil 16 (2004) 533-542
21. Ghosh SK, Pandolfino JE, Kwiatek MA, et al. Esophageal peristaltic transition zone defects: real but few and far between. Neurogastroenterol Motil. In press.
22. Kahrilas P.J., Ghosh S.K., and Pandolfino J.E. Challenging the limits of esophageal manometry. Gastroenterology 134 (2008) 16-18
23. Brasseur J.G., Ulerich R., Dai Q., et al. Pharmacological dissection of the human gastro-oesophageal segment into three sphincter components. J Physiol 580 (2007) 961-975
24. Williams R.B., Pal A., Brasseur J.G., et al. Space-time pressure structure of pharyngo-esophageal segment during swallowing. Am J Physiol 281 (2001) G1290-G1300
25. Pal A., Williams R.B., Cook I.J., et al. Intrabolus pressure gradient identifies pathological constriction in the upper esophageal sphincter during flow. Am J Physiol 285 (2003) G1037-G1048
26. Williams R.B., Wallace K.L., Ali G.B., et al. Biomechanics of failed deglutitive upper esophageal sphincter relaxation in neurogenic dysphagia. Am J Physiol 283 (2002) G16-G26
27. Tutuian R., and Castell D.O. Clarification of the esophageal function defect in patients with manometric ineffective esophageal motility: studies using combined impedance-manometry. Clin Gastroenterol Hepatol 2 (2004) 230-236
28. Pandolfino J.E., Zhang Q., Ghosh S.K., et al. Upper sphincter function during transient lower esophageal sphincter relaxation (tLESR); it's mainly about microburps. Neurogastroenterol Motil 19 (2007) 203-210
29. Silny J. Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 3 (1991) 151-162
30. Dantas R., Hara S., Oliveira R., et al. Esophageal volume clearance can be accurately assessed with intraluminal electrical impedance. Gastroenterology 124 (2003) A538
31. Imam H., Shay S., Ali A., et al. Bolus transit patterns in healthy subjects: a study using simultaneous impedance monitoring, videoesophagram, and esophageal manometry. Am J Physiol Gastrointest Liver Physiol 288 (2005) G1000-G1006
32. Shay S., and Richter J. Direct comparison of impedance, manometry, and pH probe in detecting reflux before and after a meal. Dig Dis Sci 50 (2005) 1584-1590
33. Sifrim D., Silny J., Holloway R.H., et al. Patterns of gas and liquid reflux during transient lower oesophageal sphincter relaxation: a study using intraluminal electrical impedance. Gut 44 (1999) 47-54
34. Simren M., Silny J., Holloway R., et al. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Gut 52 (2003) 784-790
35. Srinivasan R., Vela M.F., Katz P.O., et al. Esophageal function testing using multichannel intraluminal impedance. Am J Physiol Gastrointest Liver Physiol 280 (2001) 457-462
36. van Wijk M.P., Sifrim D., Rommel N., et al. Characterisation of intraluminal impedance patterns associated with gas reflux (belching) in healthy volunteers. Gastroenterology 130 (2006) A116
37. Sifrim D., Castell D., Dent J., et al. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 53 (2004) 1024-1031
38. Tutuian R., Vela M.F., Balaji N.S., et al. Esophageal function testing with combined multichannel intraluminal impedance and manometry: multicenter study in healthy volunteers. Clin Gastroenterol Hepatol 1 (2003) 174-182
39. Lopez-Alonso M., Moya M.J., Cabo J.A., et al. Twenty-four hour esophageal impedance-pH monitoring in healthy preterm neonates: rate and characteristics of acid, weakly acidic, and weakly alkaline gastroesophageal reflux. Pediatrics 118 (2006) e299-e308
40. Woodley F.W., and Mousa H. Acid gastroesophageal reflux reports in infants: a comparison of esophageal pH monitoring and multichannel intraluminal impedance measurements. Dig Di Sci 51 (2006) 1910-1916
41. Zerbib F., Roman S., Ropert A., et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 101 (2006) 1956-1963
42. Rosen R., Lord C., and Nurko S. The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children. Clin Gastroenterol Hepatol 4 (2006) 167-172
43. Agrawal A., Tutuian R., Hila A., et al. Ingestion of acidic foods mimics gastroesophageal reflux during pH monitoring. Dig Dis Sci 50 (2005) 1916-1920
44. Kahrilas P.J., Dodds W.J., Hogan W.J., et al. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 91 (1986) 897-904
45. Kahrilas P.J., Dodds W.J., and Hogan W.J. Effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology 94 (1988) 73-80
46. Massey B.T., Dodds W.J., Hogan W.J., et al. Abnormal esophageal motility. An analysis of concurrent radiographic and manometric findings. Gastroenterology 101 (1991) 344-354
47. Nguyen H.N., Domingues G.R., Winograd R., et al. Impedance characteristics of normal oesophageal motor function. Eur J Gastroenterol Hepatol 15 (2003) 773-780
48. Nguyen N.Q., Rigda R., Tippett M., et al. Assessment of oesophageal motor function using combined perfusion manometry and multi-channel intra-luminal impedance measurement in normal subjects. Neurogastroenterol Motil 17 (2005) 458-465
49. Tutuian R., Vela M.F., Balaji N.S., et al. Esophageal function testing with combined multichannel intraluminal impedance and manometry: multicenter study in healthy volunteers. Clin Gastroenterol Hepatol 1 (2003) 174-182
50. Nguyen N.Q., Rigda R., Tippett M., et al. Assessment of oesophageal motor function using combined perfusion manometry and multi-channel intra-luminal impedance measurement in normal subjects. Neurogastroenterol Motil 17 (2005) 458-465
51. Kammanolis G., Lerut T., Silny J., et al. One to one relationship between esophageal contractions, bolus transit and perception of dysphagia in healthy subjects and patients with GERD. Gastroenterology 130 (2006) A393-A394
52. Conchillo J.M., Nguyen N.Q., Samsom M., et al. Multichannel intraluminal impedance monitoring in the evaluation of patients with non-obstructive dysphagia. Am J Gastroenterol 100 (2005) 2624-2632
53. Shay S., Tutuian R., Sifrim D., et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol 99 (2004) 1037-1043
54. Sifrim D., Holloway R., Silny J., et al. Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings. Gastroenterology 120 (2001) 1588-1598
55. Zentilin P., Iiritano E., Dulbecco P., et al. Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. Dig Liver Dis 38 (2006) 226-232
56. Zerbib F., des Varannes S.B., Roman S., et al. Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a Belgian-French cohort of healthy subjects. Aliment Pharmacol Ther 22 (2005) 1011-1021
57. Zerbib F., des Varannes S.B., Roman S., et al. Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a Belgian-French cohort of healthy subjects. Aliment Pharmacol Ther 22 (2005) 1011-1021
58. Bredenoord A.J., Weusten B.L., Timmer R., et al. Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 100 (2005) 265-269
59. Bredenoord A.J., Weusten B.L., Curvers W.L., et al. Determinants of perception of heartburn and regurgitation. Gut 55 (2006) 313-318
60. Bredenoord A.J., Weusten B.L., Timmer R., et al. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol 101 (2006) 453-459
61. Vela M.F., Camacho-Lobato L., Srinivasan R., et al. Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology 120 (2001) 1599-1606
62. Mainie I., Tutuian R., Shay S., et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 55 (2006) 1398-1402
63. Weusten B.L.A.M., Roelofs J.M.M., Akkermans L.M.A., et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 107 (1994) 1741-1745
64. Kahrilas P.J. When proton pump inhibitors fail. (editorial). Clin Gastroenterol Hepatol 6 (2008) 482-483
65. Katz P., Gideon R.M., and Tutuian R. Reflux symptoms on twice daily (BID) proton pump inhibitor (PPI) associated with non acid reflux; a manifestation of hypersensitive esophagus?. (abstract). Gastroenterology 128 (2005) A130
66. Zerbib F., Duriez A., Roman S., et al. Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut 57 (2008) 156-160
67. Blondeau K., Dupont L.J., Mertens V., et al. Improved diagnosis of gastro-oesophageal reflux in patients with unexplained chronic cough. Aliment Pharmacol Ther 25 (2007) 723-732
68. Pace F., Sangaletti O., Pallotta S., et al. Biliary reflux and non-acid reflux are two distinct phenomena: a comparison between 24-hour multichannel intraesophageal impedance and bilirubin monitoring. Scand J Gastroenterol 42 (2007) 1031-1039
69. Sifrim D. Acid, weakly acidic and non-acid gastro-oesophageal reflux: differences, prevalence and clinical relevance. Eur J Gastroenterol Hepatol 16 (2004) 823-830
70. Vaezi M.F., Lacamera R.G., and Richter J.E. Validation studies of Bilitec 2000: an ambulatory duodenogastric reflux monitoring system. Am J Physiol 267 (1994) G1050-G1057
71. Emerenziani S., Sifrim D., Habib F.I., et al. Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus. Gut 57 (2008) 443-447
72. Conchillo J.M., Schwartz M.P., Selimah M., et al. Acid and non-acid reflux patterns in patients with erosive esophagitis and non-erosive reflux disease (NERD): a study using intraluminal impedance monitoring. Dig Dis Sci (2007) Oct 13 [Epub ahead of print]
73. Mousa H., and Woodley F.W. Non-acid gastroesophageal reflux and respiratory disorders: a literature review. Ohio J Sci 106 (2006) 112-116
74. Magista A.M., Indrio F., Baldassarre M., et al. Multichannel intraluminal impedance to detect relationship between gastroesophageal reflux and apnoea of prematurity. Dig Liver Dis 39 (2007) 216-221
75. Wenzl T.G., Schenke S., Peschgens T., et al. Association of apnea and nonacid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol 31 (2001) 144-149
76. Mousa H., Woodley F.W., Metheney M., et al. Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr 41 (2005) 169-177
77. Peter C.S., Sprodowski N., Bohnhorst B., et al. Gastroesophageal reflux and apnea of prematurity: no temporal relationship. Pediatrics 109 (2002) 8-11
78. Rosen R., and Nurko S. The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms. Am J Gastroenterol 99 (2004) 2452-2458
79. Mainie I., Tutuian R., Agrawal A., et al. Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring. Thorax 60 (2005) 521-523
80. Sifrim D., Dupont L., Blondeau K., et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 54 (2005) 449-454
81. Blondeau K., Mertens V., Vanaudenaerde B.A., et al. Gastro-esophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 31 (2008) 707-713
82. Anandasabapathy S., and Jaffin B.W. Multichannel intraluminal impedance in the evaluation of patients with persistent globus on proton pump inhibitor therapy. Ann Otol Rhinol Laryngol 115 (2006) 563-570
83. Kawamura O., Aslam M., Rittmann T., et al. Physical and pH properties of gastroesophagopharyngeal refluxate: a 24-hour simultaneous ambulatory impedance and pH monitoring study. Am J Gastroenterol 99 (2004) 1000-1010
84. Vela M.F., Tutuian R., Katz P.O., et al. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther 17 (2003) 243-251
85. Sifrim D., Tack J., Arts J., et al. Baclofen reduces weakly acidic reflux in ambulant patients with GERD. Gastroenterology 128 (2005) A531
86. Zentilin P., Dulbecco P., Savarino E., et al. An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry. Aliment Pharmacol Ther 21 (2005) 29-34
87. Conchillo J.M., Schwartz M.P., Selimah M., et al. Role of intra-oesophageal impedance monitoring in the evaluation of endoscopic gastroplication for gastro-oesophageal reflux disease. Aliment Pharmacol Ther 26 (2007) 61-68
88. Roman S., Poncet G., Serraj I., et al. Characterization of reflux events after fundoplication using combined impedance-pH recording. Br J Surg 94 (2007) 48-52
89. Bredenoord A.J., Draaisma W.A., Weusten B.L., et al. Mechanisms of acid, weakly acidic and gas reflux after anti-reflux surgery. Gut 57 (2008) 161-166
90. Mainie I., Tutuian R., Agrawal A., et al. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 93 (2006) 1483-1487
91. Tutuian R., Mainie I., Agrawal A., et al. Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest 130 (2006) 386-391
92. Becker V., Bajbouj M., Waller K., et al. Clinical trial: persistent gastro-oesophageal reflux symptoms despite standard therapy with proton pump inhibitors-a follow-up study of intraluminal-impedance guided therapy. Aliment Pharmacol Ther 26 (2007) 1355-1360
93. Chial H.J., Camilleri M., Williams D.E., et al. Rumination syndrome in children and adolescents: diagnosis, treatment, and prognosis. Pediatrics 111 (2003) 158-162
94. Malcolm A., Thumshirn M.B., Camilleri M., et al. Rumination syndrome. Mayo Clin Proc 72 (1997) 646-652
95. Khan S., Hyman P.E., Cocjin J., et al. Rumination syndrome in adolescents. J Pediatr 136 (2000) 528-531
96. Tutuian R., and Castell D.O. Rumination documented by using combined multichannel intraluminal impedance and manometry. Clin Gastroenterol Hepatol 2 (2004) 340-343
97. Rommel N., Tack J., and Sifrim D. Improved diagnosis of rumination using impedance-manometry. Gastroenterology 132 (2007) A594
98. Bredenoord A.J., Weusten B.L., Sifrim D., et al. Aerophagia, gastric, and supragastric belching: a study using intraluminal electrical impedance monitoring. Gut 53 (2004) 1561-1565
99. Bredenoord A.J., Weusten B.L., Timmer R., et al. Psychological factors affect the frequency of belching in patients with aerophagia. Am J Gastroenterol 101 (2006) 2777-2781
100. Bredenoord A.J., Weusten B.L., Timmer R., et al. Air swallowing, belching, and reflux in patients with gastroesophageal reflux disease. Am J Gastroenterol 101 (2006) 1721-1726
101. Conchillo J.M., Selimah M., Bredenoord A.J., et al. Air swallowing, belching, acid and non-acid reflux in patients with functional dyspepsia. Aliment Pharmacol Ther 25 (2007) 965-971
102. Nguyen H.N., Domingues G.R., Winograd R., et al. Impedance characteristics of esophageal motor function in achalasia. Dis Esophagus 17 (2004) 44-50
103. Conchillo J.M., Selimah M., Bredenoord A.J., et al. Assessment of oesophageal emptying in achalasia patients by intraluminal impedance monitoring. Neurogastroenterol Motil 18 (2006) 971-977
104. Mainie I., Tutuian R., Patel A., et al. Regional esophageal dysfunction in scleroderma and achalasia using multichannel intraluminal impedance and manometry. Dig Dis Sci 53 (2008) 210-216
105. Tutuian R., Mainie I., Agrawal A., et al. Symptom and function heterogenicity among patients with distal esophageal spasm: studies using combined impedance-manometry. Am J Gastroenterol 101 (2006) 464-469
106. Tutuian R., and Castell D.O. Combined multichannel intraluminal impedance and manometry clarifies esophageal function abnormalities: study in 350 patients. Am J Gastroenterol 99 (2004) 1011-1019
107. Cho Y.K., Choi M.G., Park J.M., et al. Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry. World J Gastroenterol 12 (2006) 6349-6354
108. Tutuian R., and Castell D.O. Clarification of the esophageal function defect in patients with manometric ineffective esophageal motility: studies using combined impedance-manometry. Clin Gastroenterol Hepatol 2 (2004) 230-236
109. Quiroga E., Cuenca-Abente F., Flum D., et al. Impaired esophageal function in morbidly obese patients with gastroesophageal reflux disease: evaluation with multichannel intraluminal impedance. Surgical Endoscopy and Other Interventional Techniques 20 (2006) 739-743
110. Montenovo M.I., Tatum R., Figueredo E., et al. Does combined multichannel intraluminal esophageal impedance and manometry predict postoperative dysphagia after laparoscopic Nissen fundoplication?. Am J Gastroenterol 102 (2007) S141
111. Kammanolis G., Lerut T., Silny J., et al. One to one relationship between esophageal contractions, bolus transit and perception of dysphagia in healthy subjects and patients with GERD. Gastroenterology 130 (2006) A393-A394
112. Agrawal A., Hila A., Tutuian R., et al. Bethanechol improves smooth muscle function in patients with severe ineffective esophageal motility. J Clin Gastroenterol 41 (2007) 366-370