Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 8, 2013, Pages 5859-5870

  Yang, Chen Yuan Charlie ^a   Liu, Ye ^b   Lu, Zhaozeng ^c   Ren, Ruiyi ^a   Gong, Haiyan ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Confocal and electron microscopy; Effective filtration area; Light; Morphology; Outflow facility; Rho kinase inhibitor; Trabecular meshwork; Y27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL) CYCLOHEXANECARBOXAMIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; AQUEOUS HUMOR OUTFLOW; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN; HYDRODYNAMICS; MORPHOLOGY; PRIORITY JOURNAL; TRABECULAR MESHWORK;

CONFOCAL AND ELECTRON MICROSCOPY; EFFECTIVE FILTRATION AREA; LIGHT; MORPHOLOGY; OUTFLOW FACILITY; RHO-KINASE INHIBITOR; TRABECULAR MESHWORK; Y27632;

ADULT; AGED; AGED, 80 AND OVER; AMIDES; AQUEOUS HUMOR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MIDDLE AGED; PYRIDINES; REGRESSION ANALYSIS; RHO-ASSOCIATED KINASES; TRABECULAR MESHWORK;

EID: 84883228632     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10930     Document Type: Article

References (41)

1. Grant WM. Experimental aqueous perfusion in enucleated human eyes. Arch Ophthalmol. 1963;69:783-801.
2. Johnson M. 'What controls aqueous humour outflow resistance?' Exp Eye Res. 2006;82:545-557.
3. Tamm ER, Fuchshofer R. What increases outflow resistance in primary open-angle glaucoma? Surv Ophthalmol. 2007; 52(suppl 2):S101-S104.
4. Overby DR, Stamer WD, Johnson M. The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. Exp Eye Res. 2009;88: 656-670.
5. Gong H, Freddo TF. The washout phenomenon in aqueous outflow-why does it matter? Exp Eye Res. 2009;88:729-737.
6. Johnson DH. The effect of cytochalasin D on outflow facility and the trabecular meshwork of the human eye in perfusion organ culture. Invest Ophthalmol Vis Sci. 1997;38:2790-2799.
7. Kaufman PL, Erickson KA. Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey. Invest Ophthalmol Vis Sci. 1982;23:646-650.
8. Tian B, Gabelt BT, Geiger B, Kaufman PL. Combined effects of H-7 and cytochalasin B on outflow facility in monkeys. Exp Eye Res. 1999;68:649-655.
9. Ethier CR, Read AT, Chan DW. Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. Invest Ophthalmol Vis Sci. 2006;47:1991-1998.
10. Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp Eye Res. 2006;82: 236-246.
11. Bahler CK, Hann CR, Fautsch MP, Johnson DH. Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes. Invest Ophthalmol Vis Sci. 2004;45:2246-2254.
12. Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp Eye Res. 2004;78: 137-150.
13. Honjo M, Tanihara H, Inatani M, et al. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001;42:137-144.
14. Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 2008; 86:271-281.
15. Rao PV, Deng PF, Kumar J, Epstein DL. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci. 2001;42:1029-1037.
16. Tian B, Kaufman PL. Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys. Exp Eye Res. 2005;80:215-225.
17. Waki M, Yoshida Y, Oka T, Azuma M. Reduction of intraocular pressure by topical administration of an inhibitor of the Rhoassociated protein kinase. Curr Eye Res. 2001;22:470-474.
18. Fukiage C, Mizutani K, Kawamoto Y, Azuma M, Shearer TR. Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction. Biochem Biophys Res Commun. 2001;288:296-300.
19. Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Ann Rev Biochem. 1999;68:459-486.
20. Rosenthal R, Choritz L, Schlott S, et al. Effects of ML-7 and Y-27632 on carbachol-and endothelin-1-induced contraction of bovine trabecular meshwork. Exp Eye Res. 2005;80:837-845.
21. Lu Z, Zhang Y, Freddo TF, Gong H. Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. Exp Eye Res. 2011;93:397-404.
22. Scott PA, Lu Z, Liu Y, Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp Eye Res. 2009;89:942-949.
23. Erickson-Lamy K, Schroeder AM, Bassett-Chu S, Epstein DL. Absence of time-dependent facility increase ("washout") in the perfused enucleated human eye. Invest Ophthalmol Vis Sci. 1990;31:2384-2388.
24. Scott PA, Overby DR, Freddo TF, Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res. 2007;84:435-443.
25. Sabanay I, Gabelt BT, Tian B, Kaufman PL, Geiger B. H-7 effects on the structure and fluid conductance of monkey trabecular meshwork. Arch Ophthalmol. 2000;118:955-962.
26. Johnson M, Shapiro A, Ethier CR, Kamm RD. Modulation of outflow resistance by the pores of the inner wall endothelium. Invest Ophthalmol Vis Sci. 1992;33:1670-1675.
27. Parc CE, Johnson DH, Brilakis HS. Giant vacuoles are found preferentially near collector channels. Invest Ophthalmol Vis Sci. 2000;41:2984-2990.
28. Ten Hulzen RD, Johnson DH. Effect of fixation pressure on juxtacanalicular tissue and Schlemm's canal. Invest Ophthalmol Vis Sci. 1996;37:114-124.
29. Alvarado JA, Yun AJ, Murphy CG. Juxtacanalicular tissue in primary open angle glaucoma and in nonglaucomatous normals. Arch Ophthalmol. 1986;104:1517-1528.
30. Grierson I, Lee WR. Light microscopic quantitation of the endothelial vacuoles in Schlemm's canal. Am J Ophthalmol. 1977;84:234-246.
31. Moses RA. Circumferential flow in Schlemm's canal. Am J Ophthalmol. 1979;88:585-591.
32. Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci. 2008;49:5346-5352.
33. Swaminathan SS, Oh DJ, Kang MH, et al. Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow. Invest Ophthalmol Vis Sci. 2013;54:2035-2047.
34. Zhang Y, Toris CB, Liu Y, Ye W, Gong H. Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma. Exp Eye Res. 2009;89:748-756.
35. Kameda T, Inoue T, Inatani M, et al. The effect of Rhoassociated protein kinase inhibitor on monkey Schlemm's canal endothelial cells. Invest Ophthalmol Vis Sci. 2012;53: 3092-3103.
36. Amano M, Ito M, Kimura K, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem. 1996;271:20246-20249.
37. Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245-248.
38. Kureishi Y, Kobayashi S, Amano M, et al. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem. 1997;272:12257-12260.
39. Rao PV, Deng P, Sasaki Y, Epstein DL. Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. Exp Eye Res. 2005;80: 197-206.
40. Zhou EH, Krishnan R, Stamer WD, et al. Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. J R Soc Interface. 2012;9:1144-1155.
41. Epstein DL, Rohen JW. Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. Invest Ophthalmol Vis Sci. 1991;32:160-171.