Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes

Experimental Eye Research

Volumn 93, Issue 4, 2011, Pages 397-404

  Lu, Zhaozeng ^a   Zhang, Yuyan ^a   Freddo, Thomas F ^b   Gong, Haiyan ^c  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF WATERLOO   (Canada)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aqueous outflow facility; Confocal microscopy; Electron microscopy; Juxtacanalicular tissue; Light microscopy; Monkey eye; Schlemm's canal; Trabecular meshwork; Washout; Y27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; MICROSPHERE;

AQUEOUS HUMOR OUTFLOW; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HAPLORHINI; HYDRODYNAMICS; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

AMIDES; ANIMALS; AQUEOUS HUMOR; ENZYME INHIBITORS; FLUORESCENT DYES; HYDRODYNAMICS; MACACA MULATTA; MICROSCOPY, CONFOCAL; MICROSPHERES; PYRIDINES; RHO-ASSOCIATED KINASES; TRABECULAR MESHWORK;

EID: 80055060174     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.05.012     Document Type: Article

References (49)

1. Bahler C.K., Hann C.R., Fautsch M.P., Johnson D.H. Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci. 2004, 45:2246-2254.
2. Barany E.H., Scotchbrook S. Influence of testicular hyaluronidase on the resistance to flow through the angle of the anterior chamber. Acta Physiol. Scand. 1954, 30:240-248.
3. Barany E.H., Woodin A.M. Hyaluronic acid and hyaluronidase in the aqueous humour and the angle of the anterior chamber. Acta Physiol. Scand. 1955, 33:257-290.
4. Battista S.A., Lu Z., Hofmann S., Freddo T., Overby D.R., Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest. Ophthalmol. Vis. Sci. 2008, 49:5346-5352.
5. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 2000, 351:95-105.
6. Epstein D.L. Open angle glaucoma. Why not a cure?. Arch. Ophthalmol. 1987, 105:1187-1188.
7. Epstein D.L., Rohen J.W. Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. Invest. Ophthalmol. Vis. Sci. 1991, 32:160-171.
8. Erickson-Lamy K., Rohen J.W., Grant W.M. Outflow facility studies in the perfused bovine aqueous outflow pathways. Curr. Eye Res. 1988, 7:799-807.
9. Erickson-Lamy K., Schroeder A.M., Bassett-Chu S., Epstein D.L. Absence of time-dependent facility increase (" washout" ) in the perfused enucleated human eye. Invest. Ophthalmol. Vis. Sci. 1990, 31:2384-2388.
10. Erickson K.A., Kaufman P.L. Comparative effects of three ocular perfusates on outflow facility in the cynomolgus monkey. Curr. Eye Res. 1981, 1:211-216.
11. Ethier C.R., Read A.T., Chan D.W. Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. Invest. Ophthalmol. Vis. Sci. 2006, 47:1991-1998.
12. Gong H., Tripathi R.C., Tripathi B.J. Morphology of the aqueous outflow pathway. Microsc. Res. Tech. 1996, 33:336-367.
13. Gong H., Freddo T.F. The washout phenomenon in aqueous outflow-why does it matter?. Exp. Eye Res. 2009, 88:729-737.
14. Gong H.Y., Trinkaus-Randall V., Freddo T.F. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr. Eye Res. 1989, 8:1071-1082.
15. Grant W.M. Further studies on facility of flow through the trabecular meshwork. AMA Arch. Ophthalmol. 1958, 60:523-533.
16. Grant W.M. Experimental aqueous perfusion in enucleated human eyes. Arch. Ophthalmol. 1963, 69:783-801.
17. Hashimoto J.M., Epstein D.L. Influence of intraocular pressure on aqueous outflow facility in enucleated eyes of different mammals. Invest. Ophthalmol. Vis. Sci. 1980, 19:1483-1489.
18. Honjo M., Inatani M., Kido N., Sawamura T., Yue B.Y., Honda Y., Tanihara H. Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch. Ophthalmol. 2001, 119:1171-1178.
19. Honjo M., Tanihara H., Inatani M., Kido N., Sawamura T., Yue B.Y., Narumiya S., Honda Y. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest. Ophthalmol. Vis. Sci. 2001, 42:137-144.
20. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., Narumiya S. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol. Pharmacol. 2000, 57:976-983.
21. Johnson D.H. The effect of cytochalasin D on outflow facility and the trabecular meshwork of the human eye in perfusion organ culture. Invest. Ophthalmol. Vis. Sci. 1997, 38:2790-2799.
22. Johnson M., Johnson D.H., Kamm R.D., DeKater A.W., Epstein D.L. The filtration characteristics of the aqueous outflow system. Exp. Eye Res. 1990, 50:407-418.
23. Johnson M., Erickson K. Mechanisms and Routes of Aqueous Humor Drainage 2000, WB Sanders Co., Philadelphia, USA.
24. Kaibuchi K., Kuroda S., Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu. Rev. Biochem. 1999, 68:459-486.
25. Kaufman P.L., Erickson K.A. Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey. Invest. Ophthalmol. Vis. Sci. 1982, 23:646-650.
26. Kaufman P.L., True-Gabelt B., Erickson-Lamy K.A. Time-dependence of perfusion outflow facility in the cynomolgus monkey. Curr. Eye Res. 1988, 7:721-726.
27. Lu Z., Overby D.R., Scott P.A., Freddo T.F., Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp. Eye Res. 2008, 86:271-281.
28. Lutjen-Drecoll E. Functional morphology of the trabecular meshwork in primate eyes. Prog. Retin. Eye Res. 1999, 18:91-119.
29. Maepea O., Bill A. The pressures in the episcleral veins, Schlemm's canal and the trabecular meshwork in monkeys: effects of changes in intraocular pressure. Exp. Eye Res. 1989, 49:645-663.
30. Maepea O., Bill A. Pressures in the juxtacanalicular tissue and Schlemm's canal in monkeys. Exp. Eye Res. 1992, 54:879-883.
31. Melton C.E., DeVille W.B. Perfusion studies on eyes of four species. Am. J. Ophthalmol. 1960, 50:302-308.
32. Overby D., Gong H., Qiu G., Freddo T.F., Johnson M. The mechanism of increasing outflow facility during washout in the bovine eye. Invest. Ophthalmol. Vis. Sci. 2002, 43:3455-3464.
33. Parc C.E., Johnson D.H., Brilakis H.S. Giant vacuoles are found preferentially near collector channels. Invest. Ophthalmol. Vis. Sci. 2000, 41:2984-2990.
34. Rao P.V., Deng P.F., Kumar J., Epstein D.L. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest. Ophthalmol. Vis. Sci. 2001, 42:1029-1037.
35. Rohen J.W., Futa R., Lutjen-Drecoll E. The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Ophthalmol. Vis. Sci. 1981, 21:574-585.
36. Rosenthal R., Choritz L., Schlott S., Bechrakis N.E., Jaroszewski J., Wiederholt M., Thieme H. Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork. Exp. Eye Res. 2005, 80:837-845.
37. Sabanay I., Tian B., Gabelt B.T., Geiger B., Kaufman P.L. Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp. Eye Res. 2004, 78:137-150.
38. Sabanay I., Tian B., Gabelt B.T., Geiger B., Kaufman P.L. Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp. Eye Res. 2006, 82:236-246.
39. Scott P.A., Overby D.R., Freddo T.F., Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp. Eye Res. 2007, 84:435-443.
40. Scott P.A., Lu Z., Liu Y., Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp. Eye Res. 2009, 89:942-949.
41. Sit A.J., Coloma F.M., Ethier C.R., Johnson M. Factors affecting the pores of the inner wall endothelium of Schlemm's canal. Invest. Ophthalmol. Vis. Sci. 1997, 38:1517-1525.
42. Sit A.J., Gong H., Ritter N., Freddo T.F., Kamm R., Johnson M. The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye. Exp. Eye Res. 1997, 64:813-821.
43. Tian B., Gabelt B.T., Geiger B., Kaufman P.L. Combined effects of H-7 and cytochalasin B on outflow facility in monkeys. Exp. Eye Res. 1999, 68:649-655.
44. Tian B., Kaufman P.L. Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys. Exp. Eye Res. 2005, 80:215-225.
45. Toris C.B., Zhan G.L., Wang Y.L., Zhao J., McLaughlin M.A., Camras C.B., Yablonski M.E. Aqueous humor dynamics in monkeys with laser-induced glaucoma. J. Ocul. Pharmacol. Ther. 2000, 16:19-27.
46. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., Tamakawa H., Yamagami K., Inui J., Maekawa M., Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997, 389:990-994.
47. Van Buskirk E.M., Brett J. The canine eye: in vitro dissolution of the barriers to aqueous outflow. Invest. Ophthalmol. Vis. Sci. 1978, 17:258-271.
48. Waki M., Yoshida Y., Oka T., Azuma M. Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase. Curr. Eye Res. 2001, 22:470-474.
49. Yan D.B., Trope G.E., Ethier C.R., Menon I.A., Wakeham A. Effects of hydrogen peroxide-induced oxidative damage on outflow facility and washout in pig eyes. Invest. Ophthalmol. Vis. Sci. 1991, 32:2515-2520.