Novel biomimetic thermosensitive β-tricalcium phosphate/chitosan-based hydrogels for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 101, Issue 10, 2013, Pages 2984-2993

  Dessi M ^a   Borzacchiello, A ^a   Mohamed, Tawheed H A ^b   Abdel Fattah, Wafa I ^b   Ambrosio, L ^a  

^a CNR   (Italy)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

TCP nanopowders; bone tissue engineering; crosslinked chitosan; thermosensitive hydrogels

Indexed keywords

BONE TISSUE ENGINEERING; CROSS LINKED CHITOSAN; FOURIER TRANSFORM INFRARED STUDIES; NANO POWDERS; THERMO-SENSITIVE HYDROGEL; THREE-DIMENSIONAL NETWORKS; TISSUE ENGINEERING APPLICATIONS; TRI-CALCIUM PHOSPHATES;

BIOMIMETICS; BONE; CHITOSAN; PHOSPHOLIPIDS; SCANNING ELECTRON MICROSCOPY; SOL-GELS; TISSUE; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

HYDROGELS;

CALCIUM PHOSPHATE; CHITOSAN; GLYCEROL 2 PHOSPHATE; NANOCRYSTAL;

ARTICLE; BIOMIMETICS; BODY TEMPERATURE; BONE TISSUE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; TISSUE ENGINEERING; TISSUE REGENERATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

BONE TISSUE ENGINEERING; CROSSLINKED CHITOSAN; THERMOSENSITIVE HYDROGELS; Β-TCP NANOPOWDERS;

BIOMIMETIC MATERIALS; BONE AND BONES; CALCIUM PHOSPHATES; CELL LINE; CHITOSAN; GLYOXAL; HUMANS; HYDROGELS; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; RHEOLOGY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS; TEMPERATURE; THERMOGRAVIMETRY; TIME FACTORS; TISSUE ENGINEERING; X-RAY DIFFRACTION;

EID: 84883223489     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34592     Document Type: Article

References (68)

1. Holy CE, Volenec FJ, Geesin J, Bruder SP,. Bone regeneration. In:, Lanza R, Langer R, Vacanti J, editors. Principle of Tissue Engineering, 3rd ed. Academic Press; p 845-860.
2. David DB, Kizhner TA, Kohler T, Müller R, Livne E, Srouj S,. Cell-scaffold transplant of hydrogel seeded with rat bone marrow progenitors for bone regeneration. J Craniomaxillofac Surg 2011; 39: 364-371.
3. Kofron MD, Li X, Laurencin CT,. Protein and gene based tissue engineering in bone repair. Curr Opin Biotechnol 2004; 15: 399-405.
4. Ma PX,. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 2008; 60: 184-198.
5. Causa F, Netti PA, Ambrosio L,. A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue. Biomaterials 2007; 28: 5093-5099.
6. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543.
7. Kim CW, Talac R, Lu L, Moore MJ, Currier BL, Yaszemski MJ,. Characterization of porous injectable poly-(propylene fumarate)-based bone graft substitute. J Biomed Mater Res A 2008; 85: 1114-1119.
8. Boccaccini AR, Erol M, Stark WJ, Mohn D, Hong Z, Mano J,. Polymer/bioactive glass nanocomposite for biomedical applications: A review. Comp Sci Technol 2010; 70: 1764-1776.
9. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
10. Dessì M, Raucci MG, Zeppetelli S, Ambrosio L,. Design of injectable organic-inorganic hybrid for bone tissue repair. J Biomed Mater Res A 2012; 100A: 2063-2070.
11. Choi D, Kumta PN,. Mechano-chemical synthesis and characterization of nanostructured β-TCP powder. Mater Sci Eng C 2007; 27: 377-381.
12. Blouin S, Moreau MF, Weiss P, Daculsi G, MF Basle, Chappard D,. Evaluation of an injectable bone substitute (βTCP/hydroxyapatite/hydroxy- propyl-methyl-cellulose) in severely osteopenic and aged rats. J Biomed Mater Res A 2006; 78: 570-580.
13. Hassna R, Ramay R, Zhang M,. Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering. Biomaterials 2004; 25: 5171-5180.
14. Horch HH, Sader R, Pautke C, Neff A, Deppe H, Kolk A,. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws. Int J Oral Maxillofac Surg 2006; 35: 708-713.
15. Augustine R, Kalappura UG, Laheurte J, Mathew KT,. Biocompatibility study of beta tricalcium phosphate biceramics and chitosan biopolymer and their use as phantoms for medical imaging applications. Microw Opt Tech Lett 2009; 51: 2923-2927.
16. Honarkar H, Barikani M,. Applications of biopolymers I: Chitosan. Monatsh Chem 2009; 140: 1403-1420.
17. Yan J, Yang L, Wang G, Xiao Y, Zhang B, Nianmin Q,. Biocompatibility evaluation of chitosan-based injectable hydrogels for the culturing mice mesenchymal stem cells in vitro. J Biomater Appl 2010; 24: 625-637.
18. Jayachandran VJ, Kim SK,. Chitosan composites for bone tissue engineering-An overview. Mar Drugs 2010; 8: 2252-2266.
19. Dash M, Chiellini F, Ottenbrite RM, Chiellini E,. Chitosan-A versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci 2011; 36: 981-1014.
20. Bergera J, Reista M, Mayera JM, Feltb O, Gurny R,. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004; 57: 35-52.
21. Muzzarelli R, Muzzarelli C,. Chitosan chemistry: Relevance to the biomedical sciences. Adv Polym Sci 2005; 186: 151-209.
22. Lin LC, Chang S, Kuo SM, Chen SF, Kuo CH,. Evaluation of chitosan/β-tricalcium phosphate microspheres as a constituent to PMMA cement. J Mater Sci Mater Med 2005; 16: 567-574.
23. Zhang Y, Zhang M,. Cell growth and function on calcium phosphate reinforced chitosan scaffolds. J Mater Sci Mater Med 2004; 15: 255-260.
24. Moreau JL, Xu HK,. Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold. Biomaterials 2009; 30: 2675-2682.
25. Yang B, Li X, Shi S, Kong X, Guo G, Huang M, Luo F, Wei Y, Zhao X, Qian Z,. Preparation and characterization of a novel chitosan scaffold. Carbohydr Polym 2010; 80: 860-865.
26. Cruz DM, Gomes M, Reis RL, Moratal D, Salmerõn-Sánchez M, Ribelles JL, Mano JF,. Differentiation of mesenchymal stem cells in chitosan scaffolds with double micro and macroporosity. J Biomed Mater Res A 2010; 95: 1182-1193.
27. Song K, Qiao M, Liu T, Jiang B, Macedo HM, Ma X, Cui Z,. Preparation, fabrication and biocompatibility of novel injectable temperature-sensitive chitosan/glycerophosphate/collagen hydrogels. J Mater Sci Mater Med 2010; 21: 2835-2842.
28. Kim S, Nishimoto SK, Bumgardner JD, Haggard WO, Gaber MW, Yang Y,. A chitosan/β-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer. Biomaterials 2010; 31: 4157-4166.
29. Mano J, Sousa R, Boesel L, Neves N, Reis L,. Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: State of the art and recent developments. Compos Sci Tech 2004; 64: 789-817.
30. Butscher A, Bohner M, Hofman S, Graukler R, Muller R,. Structural and material approaches to bone tissue engineering in powder based three dimensional printing. Review Article. Acta Biomater 2011; 7: 907-920.
31. Di Martino A, Sittinger M, Risbud M,. Chitosan a versatile biopolymer for orthopedic tissue-engineerin. Biomaterials 2005; 26: 5983-5990.
32. Li X, Kong X, Wang X, Shi S, Guo G, Luo F, Zhao X, Wei Y, Qian Z,. Gel-sol-gel gelation behavior study of chitosan-inorganic phosphate solutions. Eur J Pharm Biopharm 2010; 75: 388-392.
33. Chenite A, Bauschmann M, Wang D, Chaput C, Kandani N,. Rheological characterization of thermogelling chitosan/glycerophosphate solutions. Carbohydr Polym 2001; 46: 39-47.
34. 4 ions on β-TCP synthesis and its characterization. Biomed Mater 2008; 3: 034121.
35. Abdel-Fattah WI, Jiang T, El-Tabie G, El-Bassyouni C, Laurencin CT,. Synthesis, characterization of chitosans and fabrication of sintered chitosan microsphere matrices for bone tissue engineering. Acta Biomater 2007; 3: 503-514.
36. Cho J, Heuzey M, Begin A, Carreau PJ,. Physical gelation of chitosan in the presence of glycerophosphate: The effect of temperature. Biomacromolecules 2005; 6: 3267-3275.
37. Martins AM, Alves CM, Kurtis Kasper F, Mikosc AG, Reis RL,. Responsive and in situ-forming chitosan scaffolds for bone tissue engineering applications: an overview of the last decade. J Mater Chem 2010; 20: 1638-1645.
38. Kempe S, Metz H, Bastrop M, Hvilsom A, Contri RV, Mader K,. Characterization of thermosensitive chitosan-based hydrogels by rheology and electron paramagnetic resonance spectroscopy. Eur J Pharm Biopharm 2008; 68: 26-33.
39. Hoemann CD, Chenite A, Sun J, Hurting M, Serreqi A, Lu Z, Rossomacha E, Buschmann MD,. Cytocompatible gel formation of chitosan glycerol phosphate solutions supplemented with hydroxyl ethyl cellulose is due to the presence of glyoxal. J. Biomed Mater. Res A 2007; 56: 521-529.
40. Wang L, Stegemann JP,. Glyoxal crosslinking of cell-seeded chitosan/collagen hydrogels for bone regeneration. Acta Biomater 2011; 7: 2410-2417.
41. Yang Q, Dou F, Liang B, Shen Q,. Studies of cross-linking reaction on chitosan fiber with glyoxal. Carbohydr Polym 2005; 59: 205-210.
42. Ganji F, Abdekhodaie MJ, Ramazani A,. Gelation time and degradation rate of chitosan-based injectable hydrogel. J Sol Gel Sci Technol 2007; 42: 47-53.
43. Chenite A, Chaput C, Wang D, Combes C, Buschmann M D, Hoemann C, Leroux JC, Atkinson BL, Binette F, Selmani A,. A novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 2000; 21: 2155-2161.
44. Xin X, Borzacchiello A, Netti PA, Ambrosio L, Nicolais L,. Hyaluronic-acid-based semi-interpenetrating materials. J Biomater Sci Polym Ed 2004; 15: 1223-1236.
45. Ferry JD,. Viscoelastic Properties of Polymers. New York: Wiley; 1970.
46. Fonkwe LG, Narsimhan G, Cha AS,. Characterization of gelation time and texture of gelatin and gelatin-polysaccharide mixed gels. Food Hydrocol 2003; 17: 871-883.
47. Linand H, Yeh CT,. Controlled release of pentoxifylline from porous chitosan-pectin scaffolds. Drug Deliv 2010; 17: 313-321.
48. Orrego CE, Valencia JS,. Preparation and characterization of chitosan membranes by using a combined freeze gelation and mild crosslinking method. Bioprocess Biosyst Eng 2009; 32: 197-206.
49. Monier M, Ayad DM, Wei Y, Sarhan AA,. Preparation and characterization of magnetic chelating resin based on chitosan for adsorption of Cu(II), Co(II), and Ni(II) ions. React Funct Polym 2010; 70: 257-266.
50. Milosavljevic NB, Milasinovic NZ, Popovic IG, Filipovic JM, Kalagasidis Krusic MT,. Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. Polym Int 2011; 60: 443-452.
51. Wang J, Hon MH,. Preparation and characterization of pH sensitive sugar mediated (polyethylene glycol/chitosan) membrane. J Mater Sci Mater Med 2003; 1: 1079-1088.
52. Khalid MN, Agnely F, Yagoubi N, Grossiord JL, Couarraze G,. Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks. Eur J Pharm Sci 2002; 15: 425-432.
53. Hattar S, Berdal A, Asselin A, Loty S, Greenspan, DC, Sautier J-M,. Behaviour of moderately differentiated osteoblast-like cells cultured in contact with bioactive glasses. Eur Cells Mater 2002; 4: 61-69.
54. Goegan P, Johnson G, Vincent R,. Effects of serum protein and colloid on the Alamar Blue assay in cell cultures. Toxic InVitro 1995; 9: 257-266.
55. Finisie MR, Josué A, Fávere VT, Laranjeira MC,. Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration. An Acad Bras Ciênc 2001; 73: 525-532.
56. Monier M, Wei Y, Sarhan AA, Ayad DM,. Synthesis and characterization of photo-crosslinkable hydrogel membranes based on modified chitosan. Polymer 2010; 5: 1002-1009.
57. Barraleta JE, Grovera LM, Gbureck U,. Ionic modification of calcium phosphate cement viscosity. Part II: Hypodermic injection and strength improvement of brushite cement. Biomaterials 2004; 25: 2197-2203.
58. Liu H, Li H, Cheng W, Yang Y, Zhu M, Zhou C,. Novel injectable calcium phosphate/chitosan composites for bone substitute materials. Acta Biomater 2006; 2: 557-565.
59. Li Y, Weng W, Tam KC,. Novel highly biodegradable biphasic tricalcium phosphates composed of a-tricalcium phosphate and b-tricalcium phosphate. Biomaterials 2004; 25: 2197-2203.
60. Liu T, Chen S, Li J, Liu D,. Study on drug release behaviour of CDHA/chitosan nanocomposites-Effect of CDHA nanoparticles. J Control Release 2006; 112: 88-95.
61. dos Santos LA, Carrodèguas RG, Rogero SO, Higa OZ, Boschi AO, de Arruda ACF,. α-Tricalcium phosphate cement: "In vitro" cytotoxicity. Biomaterials 2002; 23: 2035-2042.
62. Vazquez B, Ginebrab MP, Gilb X, Planell J, San Roman J,. Acrylic bone cements modified with β-TCP particles encapsulated with poly(ethylene glycol). Biomaterials 2005; 26: 4309-4316.
63. Dongwen R, Hongfu Y, Wei W, Xiaojun M,. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation. Carbohydr Res 2005; 340: 2403-2410.
64. Jianxi L, Descamps M, Dejou J, Koubi G, Hardouin P, Lemaitre J, Proust JP,. The biodegradation mechanism of calcium phosphate biomaterials in bone. J Biomed Mater Res A 2002; 63: 408-413.
65. Shyh MK, Shwu JC, Gregory CN, Cheng-Wen L, Wen TC, Yang CZ,. Guided tissue regeneration with use of b-TCP/chitosan composite membrane. J Appl Polym Sci 2009; 112: 3127-3134.
66. Wiltfang J, Merten HA, Schlegel KA, Schultze-Mosgau S, Kloss FR, Rupprecht S, Kessler P,. Degradation characteristics of α and βTri-calcium-phosphate (TCP) in mini pigs. J Biomed Mater Res A 2002; 63: 115-122.
67. Choi D, Kumta PN,. Mechano-chemical synthesis and characterization of nanostructured β-TCP powder. Mat Sci Eng C 2007; 27: 377-381.
68. Zhou H, Lee J,. Nanosized hydroxyapatite particles for bone tissue engineering. Acta Biomater 2011; 7: 2769-2781.