How I treat heterozygous hereditary antithrombin deficiency in pregnancy

Thrombosis and Haemostasis

Volumn 110, Issue 3, 2013, Pages 550-559

  Bramham, Kate ^a   Retter, Andrew ^b   Robinson, Susan E ^b   Mitchell, Michael ^b   Moore, Gary W ^b   Hunt, Beverley J ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Hereditary antithrombin deficiency; Pregnancy

Indexed keywords

ACETAZOLAMIDE; ANTITHROMBIN III CONCENTRATE; BLOOD CLOTTING FACTOR 10A INHIBITOR; DALTEPARIN; ENOXAPARIN; FONDAPARINUX; TINZAPARIN; WARFARIN;

ADULT; ANTITHROMBIN DEFICIENCY; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; DEEP VEIN THROMBOSIS; DELIVERY; DRUG DOSE INCREASE; DRUG INTERMITTENT THERAPY; ERYTHROCYTE TRANSFUSION; FEMALE; GENE MUTATION; GENETIC DISORDER; GESTATIONAL AGE; HUMAN; LABOR; LUNG EMBOLISM; MATERNAL CARE; OBSERVATIONAL STUDY; PREGNANCY; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROPHYLAXIS; RETROSPECTIVE STUDY; SICKLE CELL ANEMIA; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

ADULT; ANTITHROMBIN III; ANTITHROMBIN III DEFICIENCY; DRUG ADMINISTRATION SCHEDULE; ENOXAPARIN; FEMALE; HUMANS; MIDDLE AGED; MUTATION; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES; RISK; THROMBOSIS; VENOUS THROMBOSIS; YOUNG ADULT;

EID: 84883216635     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-01-0077     Document Type: Article

References (34)

1. Lane DA, Bayston T, Olds RJ, et al. Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1997; 77: 197-211.
2. Roemisch J, Gray E, Hoffmann JN, et al. Antithrombin: a new look at the actions of a serine protease inhibitor. Blood Coagul Fibrinolysis 2002; 13: 657-670.
3. Haemostasis and Thrombosis Task Force, Investigation and management of heritable thrombophilia. Br J Haematol 2001; 114: 512-528.
4. Wells PS, Blajchman MA, Henderson P, et al. Prevalence of antithrombin deficiency in healthy blood donors: a cross-sectional study. Am J Hematol 1994; 45: 321-324.
5. Tait RC, Walker ID, Perry DJ, et al. Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 1994; 87: 106-112.
6. Hirsh J, Piovella F, Pini M. Congenital antithrombin III deficiency. Incidence and clinical features. Am J Med 1989; 87: 34S-8S.
7. Lockwood CJ. Inherited thrombophilias in pregnant patients: detection and treatment paradigm. Obstet Gynecol 2002; 99: 333-341.
8. Mitic G, Povazan L, Lazic R, et al. Deficiency of the natural anticoagulant proteins in women with pregnancy related venous thromboembolism. Med Pregl 2009; 62: 53-62.
9. McColl MD, Ramsay JE, Tait RC, et al. Risk factors for pregnancy associated venous thromboembolism. Thromb Haemost 1997; 78: 1183-1188.
10. Conard J, Horellou MH, Van Dreden P, et al. Thrombosis and pregnancy in congenital deficiencies in AT III, protein C or protein S: study of 78 women. Thromb Haemos. 1990; 63: 319-320.
11. Hellgren M, Tengborn L, Abildgaard U. Pregnancy in women with congenital antithrombin III deficiency: experience of treatment with heparin and antithrombin. Gynecol Obstet Invest 1982; 14: 127-141.
12. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
13. Vicente V, Rodriguez C, Soto I, et al. Risk of thrombosis during pregnancy and post-partum in hereditary thrombophilia. Am J Hematol 1994; 46: 151-152.
14. Sharpe CJ, Crowther MA, Webert KE, et al. Cerebral venous thrombosis during pregnancy in the setting of type I antithrombin deficiency: case report and literature review. Transfus Med Rev 2011; 25: 61-65.
15. Szilagyi A, Nagy A, Tamas P, et al. Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency. Gynecol Obstet Invest 2006; 61: 111-114.
16. Sabadell J, Casellas M, Alijotas-Reig J, et al. Inherited antithrombin deficiency and pregnancy: maternal and fetal outcomes. Eur J Obstet Gynecol Reprod Biol 2010; 149: 47-51.
17. Yamada T, Yamada H, Morikawa M, et al. Management of pregnancy with congenital antithrombin III deficiency: two case reports and a review of the literature. J Obstet Gynaecol Res 2001; 27: 189-197.
18. De Stefano V, Leone G, De Carolis S, et al. Management of pregnancy in women with antithrombin III congenital defect: report of four cases. Thromb Haemost 1988; 59: 193-196.
19. Nelson DM, Stempel LE, Brandt JT. Hereditary antithrombin III deficiency and pregnancy: report of two cases and review of the literature. Obstet Gynecol 1985; 65: 848-853.
20. Hunt BJ, Gattens M, Khamashta M, et al. Thromboprophylaxis with unmonitored intermediate-dose low molecular weight heparin in pregnancies with a previous arterial or venous thrombotic event. Blood Coagul Fibrinolysis 2003; 14: 735-739.
21. McAuley WJ, Hunt BJ, Ahmad HN, et al. First trimester superior sagittal sinus venous thrombosis and antithrombin deficiency. J Obstet Gynaecol 2005; 25: 808-810.
22. Folkeringa N, Brouwer JL, Korteweg FJ, et al. Reduction of high fetal loss rate by anticoagulant treatment during pregnancy in antithrombin, protein C or protein S deficient women. Br J Haematol 2007; 136: 656-661.
23. Arias F, Romero R, Joist H, et al. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 1998; 7: 277-286.
24. Perry SL, Ortel TL. Clinical and laboratory evaluation of thrombophilia. Clin Chest Med 2003; 24: 153-170.
25. Thaler E, Lechner K. Antithrombin III deficiency and thromboembolism. Clin Haematol 1981; 10: 369-390.
26. Friederich PW, Sanson BJ, Simioni P, et al. Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis. Ann Intern Med 1996; 125: 955-960.
27. Bates SM, Greer IA, Middeldorp S, et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e691S-736S
28. Maclean PS, Tait RC. Hereditary and acquired antithrombin deficiency: epidemiology, pathogenesis and treatment options. Drugs 2007; 67: 1429-1440.
29. Schulman S, Tengborn L. Treatment of venous thromboembolism in patients with congenital deficiency of antithrombin III. Thromb Haemost 1992; 68: 634-636.
30. Thomas J, Callwood A, Brocklehurst P, et al. The National Sentinel Caesarean Section Audit. Br J Obstet Gynecol 2000; 107: 579-580.
31. Paternoster DM, Fantinato S, Manganelli F, et al. Efficacy of AT in pre-eclampsia: a case-control prospective trial. Thromb Haemost 2004; 91: 283-289.
32. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
33. Martinelli I, Mannucci PM, De Stefano V, et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92: 2353-2358.
34. Finazzi G, Caccia R, Barbui T. Different prevalence of thromboembolism in the subtypes of congenital antithrombin III deficiency: review of 404 cases. Thromb Haemost 1987; 58: 1094.