Organocatalytic formal [5+1] annulation: Diastereoselective cascade synthesis of functionalized six-membered spirocyclic indane-1,3-diones/oxindoles via Michael-aldol reaction

Tetrahedron

Volumn 69, Issue 41, 2013, Pages 8751-8757

  Roy, Suparna ^a   Amireddy, Mamatha ^a   Chen, Kwunmin ^a  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

Author keywords

Cascade Michael aldol Oxindole Diastereoselectivity

Indexed keywords

(1 METHYLINDOLINE 2 ONE) 3 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' 2 THIENYLCYCHLOHEXANE]; (1 METHYLINDOLINE 2 ONE) 3 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' PHENYLCYCLOHEXANE); (2 COUMARANONE) 3 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' PHENYLCYCLOHEXANE); (INDANE 1,3 DIONE) 2 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' PHENYLCYCLOHEXANE); (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 5' NITRO 6' (2 THIENYL)CYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 5' NITRO 6' (3 NITROPHENYL)CYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 5' NITRO 6' (4 NITROPHENYL)CYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 6' (2 METHYLPHENYL) 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 6' (2 NAPHTHYL) 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 6' (3,4 METHYLENEDIOXYPHENYL) 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 2' METHYL 6' (4 METHYLPHENYL) 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 6' (3 METHOXYPHENYL) 2' METHYL 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [2' HYDROXY 6' (4 METHOXYPHENYL) 2' METHYL 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [6' (3 BROMOPHENYL) 2' HYDROXY 2' METHYL 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [6' (4 BROMOPHENYL) 2' HYDROXY 2' METHYL 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [6' (4 CHLOROPHENYL) 2' HYDROXY 2' METHYL 5' NITROCYCLOHEXANE]; (INDANE 1,3 DIONE) 2 SPIRO 1' [6' (4 FLUOROPHENYL) 2' HYDROXY 2' METHYL 5' NITROCYCLOHEXANE]; (INDOLINE 2 ONE) 3 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' PHENYLCYCLOHEXANE); 1,3 INDANDIONE DERIVATIVE; 1,4 DIAZABICYCLO[2.2.2]OCTANE; 5 NITRO 6 ARYL HEX 5 EN 2 ONE; CYCLOHEXANE DERIVATIVE; DICHLOROMETHANE; ELECTROPHILE; NUCLEOPHILE; OXINDOLE; SPIRO COMPOUND; TERT BUTYL(INDOLIN 2 ONE) 3 SPIRO 1' (2' HYDROXY 2' METHYL 5' NITRO 6' PHENYLCYCLOHEXANE) 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ALDOL REACTION; ANNULATION REACTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; DIASTEREOISOMER; DRUG SYNTHESIS; ELECTROPHILICITY; ENVIRONMENTAL TEMPERATURE; HIGH TEMPERATURE; MICHAEL ADDITION; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 84883195511     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2013.07.084     Document Type: Article

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