-
1
-
-
77951293658
-
Taspoglutide, an analog of human glucagon-like peptide-1 with enhanced stability and in vivo potency
-
E. Sebokova, A.D. Christ, and H. Wang Taspoglutide, an analog of human glucagon-like peptide-1 with enhanced stability and in vivo potency Endocrinology 151 6 2010 2474 2482
-
(2010)
Endocrinology
, vol.151
, Issue.6
, pp. 2474-2482
-
-
Sebokova, E.1
Christ, A.D.2
Wang, H.3
-
2
-
-
70350764845
-
Pharmacokinetic and pharmacodynamic properties of taspoglutide, a once-weekly, human GLP-1 analogue, after single-dose administration in patients with Type 2 diabetes
-
C. Kapitza, T. Heise, and P. Birman Pharmacokinetic and pharmacodynamic properties of taspoglutide, a once-weekly, human GLP-1 analogue, after single-dose administration in patients with Type 2 diabetes Diabet Med 26 11 2009 1156 1164
-
(2009)
Diabet Med
, vol.26
, Issue.11
, pp. 1156-1164
-
-
Kapitza, C.1
Heise, T.2
Birman, P.3
-
3
-
-
67649523294
-
Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
-
M.A. Nauck, R.E. Ratner, and C. Kapitza Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study Diabetes Care 32 7 2009 1237 1243
-
(2009)
Diabetes Care
, vol.32
, Issue.7
, pp. 1237-1243
-
-
Nauck, M.A.1
Ratner, R.E.2
Kapitza, C.3
-
4
-
-
84863593432
-
Efficacy and safety of taspoglutide in patients with type 2 diabetes inadequately controlled with metformin plus pioglitazone over 24 weeks: T-Emerge 3 trial
-
R.R. Henry, S. Mudaliar, and L. Kanitra Efficacy and safety of taspoglutide in patients with type 2 diabetes inadequately controlled with metformin plus pioglitazone over 24 weeks: T-Emerge 3 trial J Clin Endocrinol Metab 97 7 2012 2370 2379
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.7
, pp. 2370-2379
-
-
Henry, R.R.1
Mudaliar, S.2
Kanitra, L.3
-
5
-
-
84876268373
-
Effects of taspoglutide on glycemic control and body weight in obese patients with type 2 diabetes (T-emerge 7 study)
-
P. Hollander, B. Lasko, and A.H. Barnett Effects of taspoglutide on glycemic control and body weight in obese patients with type 2 diabetes (T-emerge 7 study) Obesity 21 2 2013 238 247
-
(2013)
Obesity
, vol.21
, Issue.2
, pp. 238-247
-
-
Hollander, P.1
Lasko, B.2
Barnett, A.H.3
-
6
-
-
84871093044
-
Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. Insulin glargine titrated to target in patients with type 2 diabetes: An open-label randomized trial
-
M. Nauck, E. Horton, and M. Andjelkovic Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. insulin glargine titrated to target in patients with type 2 diabetes: an open-label randomized trial Diabet Med 30 1 2013 109 113
-
(2013)
Diabet Med
, vol.30
, Issue.1
, pp. 109-113
-
-
Nauck, M.1
Horton, E.2
Andjelkovic, M.3
-
7
-
-
84873087943
-
Efficacy and tolerability of taspoglutide versus pioglitazone in subjects with type 2 diabetes uncontrolled with sulphonylurea or sulphonylurea-metformin therapy: A randomized, double-blind study (T-emerge 6)
-
R.E. Pratley, D. Urosevic, and M. Boldrin Efficacy and tolerability of taspoglutide versus pioglitazone in subjects with type 2 diabetes uncontrolled with sulphonylurea or sulphonylurea-metformin therapy: a randomized, double-blind study (T-emerge 6) Diabetes Obes Metab 15 3 2013 234 240
-
(2013)
Diabetes Obes Metab
, vol.15
, Issue.3
, pp. 234-240
-
-
Pratley, R.E.1
Urosevic, D.2
Boldrin, M.3
-
8
-
-
84871126011
-
Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-emerge 4 trial)
-
R.M. Bergenstal, A. Forti, and J.L. Chiasson Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-emerge 4 trial) Diabet Ther 3 1 2012 13
-
(2012)
Diabet Ther
, vol.3
, Issue.1
, pp. 13
-
-
Bergenstal, R.M.1
Forti, A.2
Chiasson, J.L.3
-
9
-
-
84859073016
-
Efficacy and safety of taspoglutide monotherapy in drug-naive type 2 diabetic patients after 24 weeks of treatment: Results of a randomized, double-blind, placebo-controlled phase 3 study (T-emerge 1)
-
I. Raz, V. Fonseca, and M. Kipnes Efficacy and safety of taspoglutide monotherapy in drug-naive type 2 diabetic patients after 24 weeks of treatment: results of a randomized, double-blind, placebo-controlled phase 3 study (T-emerge 1) Diabetes Care 35 3 2012 485 487
-
(2012)
Diabetes Care
, vol.35
, Issue.3
, pp. 485-487
-
-
Raz, I.1
Fonseca, V.2
Kipnes, M.3
-
10
-
-
84874434023
-
The fate of taspoglutide, a weekly GLP-1 receptor agonist, versus twice-daily exenatide for type 2 diabetes: The T-emerge 2 trial
-
J. Rosenstock, B. Balas, and B. Charbonnel The fate of taspoglutide, a weekly GLP-1 receptor agonist, versus twice-daily exenatide for type 2 diabetes: the T-emerge 2 trial Diabetes Care 36 3 2013 498 504
-
(2013)
Diabetes Care
, vol.36
, Issue.3
, pp. 498-504
-
-
Rosenstock, J.1
Balas, B.2
Charbonnel, B.3
-
11
-
-
79953040963
-
An overview of once-weekly glucagon-like peptide-1 receptor agonists - Available efficacy and safety data and perspectives for the future
-
S. Madsbad, U. Kielgast, and M. Asmar An overview of once-weekly glucagon-like peptide-1 receptor agonists - available efficacy and safety data and perspectives for the future Diabetes Obes Metab 13 5 2011 394 407
-
(2011)
Diabetes Obes Metab
, vol.13
, Issue.5
, pp. 394-407
-
-
Madsbad, S.1
Kielgast, U.2
Asmar, M.3
-
12
-
-
55549136417
-
Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
-
R.A. DeFronzo, T. Okerson, and P. Viswanathan Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study Curr Med Res Opin 24 10 2008 2943 2952
-
(2008)
Curr Med Res Opin
, vol.24
, Issue.10
, pp. 2943-2952
-
-
Defronzo, R.A.1
Okerson, T.2
Viswanathan, P.3
-
13
-
-
81155154236
-
Liraglutide: A review of its use in the management of type 2 diabetes mellitus
-
C.M. Perry Liraglutide: a review of its use in the management of type 2 diabetes mellitus Drugs 71 17 2011 2347 2373
-
(2011)
Drugs
, vol.71
, Issue.17
, pp. 2347-2373
-
-
Perry, C.M.1
-
15
-
-
65549112678
-
Exenatide: A review from pharmacology to clinical practice
-
R. Gentilella, C. Bianchi, and A. Rossi Exenatide: a review from pharmacology to clinical practice Diabetes Obes Metab 11 6 2009 544 556
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.6
, pp. 544-556
-
-
Gentilella, R.1
Bianchi, C.2
Rossi, A.3
-
16
-
-
15444367142
-
Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
-
O.G. Kolterman, D.D. Kim, and L. Shen Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus Am J Health Syst Pharm 62 2 2005 173 181
-
(2005)
Am J Health Syst Pharm
, vol.62
, Issue.2
, pp. 173-181
-
-
Kolterman, O.G.1
Kim, D.D.2
Shen, L.3
-
17
-
-
0036066641
-
Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
-
C.B. Juhl, M. Hollingdal, and J. Sturis Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes Diabetes 51 2 2002 424 429
-
(2002)
Diabetes
, vol.51
, Issue.2
, pp. 424-429
-
-
Juhl, C.B.1
Hollingdal, M.2
Sturis, J.3
-
18
-
-
0035432607
-
Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment
-
J. Larsen, B. Hylleberg, and K. Ng Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment Diabetes Care 24 8 2001 1416 1421
-
(2001)
Diabetes Care
, vol.24
, Issue.8
, pp. 1416-1421
-
-
Larsen, J.1
Hylleberg, B.2
Ng, K.3
-
19
-
-
0037045845
-
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
-
M. Zander, S. Madsbad, and J.L. Madsen Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study Lancet 359 9309 2002 824 830
-
(2002)
Lancet
, vol.359
, Issue.9309
, pp. 824-830
-
-
Zander, M.1
Madsbad, S.2
Madsen, J.L.3
-
20
-
-
67649666737
-
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
-
J.B. Buse, J. Rosenstock, and G. Sesti Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) Lancet 374 9683 2009 39 47
-
(2009)
Lancet
, vol.374
, Issue.9683
, pp. 39-47
-
-
Buse, J.B.1
Rosenstock, J.2
Sesti, G.3
-
21
-
-
53249142132
-
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
-
D.J. Drucker, J.B. Buse, and K. Taylor Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study Lancet 372 9645 2008 1240 1250
-
(2008)
Lancet
, vol.372
, Issue.9645
, pp. 1240-1250
-
-
Drucker, D.J.1
Buse, J.B.2
Taylor, K.3
-
22
-
-
33846006173
-
The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
D.J. Drucker, and M.A. Nauck The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 9548 2006 1696 1705
-
(2006)
Lancet
, vol.368
, Issue.9548
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
23
-
-
0026504160
-
Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
-
E. Van Cauter, F. Mestrez, and J. Sturis Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance Diabetes 41 3 1992 368 377
-
(1992)
Diabetes
, vol.41
, Issue.3
, pp. 368-377
-
-
Van Cauter, E.1
Mestrez, F.2
Sturis, J.3
-
25
-
-
0021911168
-
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: Implications for human diabetes
-
A. Starke, S. Grundy, and J.D. McGarry Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes Proc Natl Acad Sci U S A 82 5 1985 1544 1546
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, Issue.5
, pp. 1544-1546
-
-
Starke, A.1
Grundy, S.2
McGarry, J.D.3
-
26
-
-
0015186838
-
Glucagon and the insulin: Glucagon ratio in diabetes and other catabolic illnesses
-
R.H. Unger Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses Diabetes 20 12 1971 834 838
-
(1971)
Diabetes
, vol.20
, Issue.12
, pp. 834-838
-
-
Unger, R.H.1
-
27
-
-
0035089445
-
A model-based method for assessing insulin sensitivity from the oral glucose tolerance test
-
A. Mari, G. Pacini, and E. Murphy A model-based method for assessing insulin sensitivity from the oral glucose tolerance test Diabetes Care 24 3 2001 539 548
-
(2001)
Diabetes Care
, vol.24
, Issue.3
, pp. 539-548
-
-
Mari, A.1
Pacini, G.2
Murphy, E.3
-
28
-
-
0942279564
-
Beta-cell dysfunction and glucose intolerance: Results from the San Antonio metabolism (SAM) study
-
A. Gastaldelli, E. Ferrannini, and Y. Miyazaki Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study Diabetologia 47 1 2004 31 39
-
(2004)
Diabetologia
, vol.47
, Issue.1
, pp. 31-39
-
-
Gastaldelli, A.1
Ferrannini, E.2
Miyazaki, Y.3
-
29
-
-
39749143348
-
Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus
-
T. Vilsbøll, B. Brock, and H. Perrild Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus Diabet Med 25 2 2008 152 156
-
(2008)
Diabet Med
, vol.25
, Issue.2
, pp. 152-156
-
-
Vilsbøll, T.1
Brock, B.2
Perrild, H.3
-
30
-
-
34249891874
-
Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
-
D. Kim, L. MacConell, and D. Zhuang Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes Diabetes Care 30 6 2007 1487 1493
-
(2007)
Diabetes Care
, vol.30
, Issue.6
, pp. 1487-1493
-
-
Kim, D.1
Macconell, L.2
Zhuang, D.3
-
31
-
-
84863331401
-
GLP-1 based therapies: Differential effects on fasting and postprandial glucose
-
M.S. Fineman, B.B. Cirincione, and D. Maggs GLP-1 based therapies: differential effects on fasting and postprandial glucose Diabetes Obes Metab 14 8 2012 675 688
-
(2012)
Diabetes Obes Metab
, vol.14
, Issue.8
, pp. 675-688
-
-
Fineman, M.S.1
Cirincione, B.B.2
Maggs, D.3
-
32
-
-
0030667056
-
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
-
M.A. Nauck, U. Niedereichholz, and R. Ettler Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans Am J Physiol 273 5 Pt 1 1997 E981 E988
-
(1997)
Am J Physiol
, vol.273
, Issue.5 PART 1
-
-
Nauck, M.A.1
Niedereichholz, U.2
Ettler, R.3
-
33
-
-
0037312821
-
The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on β-cell sensitivity in type 2 and nondiabetic subjects
-
L.L. Kjems, J.J. Holst, and A. Vølund The influence of GLP-1 on glucose-stimulated insulin secretion: effects on β-cell sensitivity in type 2 and nondiabetic subjects Diabetes 52 2 2003 380 386
-
(2003)
Diabetes
, vol.52
, Issue.2
, pp. 380-386
-
-
Kjems, L.L.1
Holst, J.J.2
Vølund, A.3
-
34
-
-
84859013614
-
Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): A 26-week double-blind study
-
D. Russell-Jones, R.M. Cuddihy, and M. Hanefeld Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study Diabetes Care 35 2 2012 252 258
-
(2012)
Diabetes Care
, vol.35
, Issue.2
, pp. 252-258
-
-
Russell-Jones, D.1
Cuddihy, R.M.2
Hanefeld, M.3
-
35
-
-
80054090833
-
Effects of exenatide on measures of beta-cell function after 3 years in metformin-treated patients with type 2 diabetes
-
M.C. Bunck, A. Corner, and B. Eliasson Effects of exenatide on measures of beta-cell function after 3 years in metformin-treated patients with type 2 diabetes Diabetes Care 34 9 2011 2041 2047
-
(2011)
Diabetes Care
, vol.34
, Issue.9
, pp. 2041-2047
-
-
Bunck, M.C.1
Corner, A.2
Eliasson, B.3
-
36
-
-
2342599057
-
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
-
K.B. Degn, C.B. Juhl, and J. Sturis One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes Diabetes 53 5 2004 1187 1194
-
(2004)
Diabetes
, vol.53
, Issue.5
, pp. 1187-1194
-
-
Degn, K.B.1
Juhl, C.B.2
Sturis, J.3
-
37
-
-
12244299450
-
Beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: A new analysis
-
E. Ferrannini, A. Gastaldelli, and Y. Miyazaki beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis J Clin Endocrinol Metab 90 1 2005 493 500
-
(2005)
J Clin Endocrinol Metab
, vol.90
, Issue.1
, pp. 493-500
-
-
Ferrannini, E.1
Gastaldelli, A.2
Miyazaki, Y.3
-
38
-
-
79956336447
-
Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects
-
E. Cersosimo, A. Gastaldelli, and A. Cervera Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects J Clin Endocrinol Metab 96 6 2011 1763 1770
-
(2011)
J Clin Endocrinol Metab
, vol.96
, Issue.6
, pp. 1763-1770
-
-
Cersosimo, E.1
Gastaldelli, A.2
Cervera, A.3
-
39
-
-
0017171586
-
Physiology and pathophysiology of glucagon
-
R.H. Unger, and L. Orci Physiology and pathophysiology of glucagon Physiol Rev 56 4 1976 778 826
-
(1976)
Physiol Rev
, vol.56
, Issue.4
, pp. 778-826
-
-
Unger, R.H.1
Orci, L.2
-
40
-
-
15444380712
-
Exenatide (exendin-4) improves insulin sensitivity and β-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
-
B.R. Gedulin, S.E. Nikoulina, and P.A. Smith Exenatide (exendin-4) improves insulin sensitivity and β-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight Endocrinology 146 4 2005 2069 2076
-
(2005)
Endocrinology
, vol.146
, Issue.4
, pp. 2069-2076
-
-
Gedulin, B.R.1
Nikoulina, S.E.2
Smith, P.A.3
-
41
-
-
80052517174
-
Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
-
G. Svegliati-Baroni, S. Saccomanno, and C. Rychlicki Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis Liver Int 31 9 2011 1285 1297
-
(2011)
Liver Int
, vol.31
, Issue.9
, pp. 1285-1297
-
-
Svegliati-Baroni, G.1
Saccomanno, S.2
Rychlicki, C.3
-
42
-
-
84871564295
-
Direct effect of GLP-1 infusion on endogenous glucose production in humans
-
M. Seghieri, E. Rebelos, and A. Gastaldelli Direct effect of GLP-1 infusion on endogenous glucose production in humans Diabetologia 56 1 2013 156 161
-
(2013)
Diabetologia
, vol.56
, Issue.1
, pp. 156-161
-
-
Seghieri, M.1
Rebelos, E.2
Gastaldelli, A.3
-
43
-
-
84864802728
-
Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes
-
E. Muscelli, A. Casolaro, and A. Gastaldelli Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes J Clin Endocrinol Metab 97 8 2012 2818 2826
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.8
, pp. 2818-2826
-
-
Muscelli, E.1
Casolaro, A.2
Gastaldelli, A.3
|