Periodontal regeneration in human class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft

International Journal of Periodontics and Restorative Dentistry

Volumn 23, Issue 3, 2003, Pages 213-225

  Camelo, Marcelo ^e   Nevins, Marc L ^a   Schenk, Robert K ^b   Lynch, Samuel E ^c   Nevins, Myron ^d,e  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c BioMimetic Therapeutics Inc   (United States)

^d Institute for Advanced Dental Studies   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBER; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB; RECOMBINANT PROTEIN;

ADULT; ARTICLE; BONE ALLOGRAFT; BONE REGENERATION; CASE REPORT; CEMENTUM; CLINICAL TRIAL; ENAMEL; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LIGAMENT; MOLAR TOOTH; PERIODONTAL DISEASE; POSTOPERATIVE PERIOD; TISSUE REGENERATION; TREATMENT OUTCOME; BONE TRANSPLANTATION; DRUG EFFECT; METHODOLOGY; MIDDLE AGED; ORAL SURGERY; PERIODONTAL LIGAMENT; REGENERATION; TISSUE ENGINEERING;

ADULT; BONE REGENERATION; BONE TRANSPLANTATION; DENTAL CEMENTUM; FEMALE; FURCATION DEFECTS; HUMANS; MIDDLE AGED; MOLAR; ORAL SURGICAL PROCEDURES; PERIODONTAL LIGAMENT; PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT PROTEINS; REGENERATION; TISSUE ENGINEERING;

EID: 0042512285     PISSN: 01987569     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Mohan S, Baylink DJ. Thereapeutic potential of TGF-β BMP, and FGF in the treatment of bone loss. In: Principles of Bone Biology. New York: Academic Press, 1996:111-123.
2. Lane JM, Tomin E, Bostrom MP. Biosynthetic bone grafting. Clin Orthop 1999;367:S107-S117.
3. Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth factor expression in normally healing human fractures. Bone 1995;16:455-460.
4. Bostrom MP, Lane JM, Berberian WS, et al. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J Orthop Res 1995;13:357-367.
5. Schatterman GC, Morrison-Graham K, Van Koppen A, Weston JA, Bowen-Pope DF. Regulation and role of PDGF receptor alpha subunit expression during embryogenesis. Development 1992;115:123-131.
6. Lynch SE, Williams RC, Polson AM, et al. A combination of platelet-derived growth factor and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16:545-548.
7. Kalkwarf K, Kadahl WP, Patel KD. Evaluation of furcation region response to periodontal therapy. J Periodontol 1988;59:794-804.
8. Pontoreiro R, Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F. Guided tissue regeneration in degree II furcation-involved mandibular molars. J Clin Periodontol 1988;15:247-254.
9. Becker W, Becker BE, Mellonig J, et al. A prospective multi-center study evaluating periodontal regeneration for Class II furcation invasions and intrabony defects after treatment with a bioabsorbable barrier membranes: 1-year results. J Periodontol 1996;67:641-649.
10. Pontoriero R, Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F. Guided tissue regeneration of furcation defects in mandibular molars. J Clin Periodontol 1989;16:170-174.
11. Lekovic V, Kenney EB, Kovacevic K, Carranza FA Jr. Evaluation of guided tissue regeneration in Class II furcation defects. A clinical reentry study. J Periodontol 1989;60:694-698.
12. Schallhorn RG, McClain PK. Combined osseous composite grafting, root conditioning, and guided tissue regeneration. Int J Periodontics Restrorative Dent 1998;8(4):9-31.
13. McClain PK, Schallhorn RG. Long-term assessment of combined osseous composite grafting, root conditioning, and guided tissue regeneration. Int J Periodontics Restorative Dent 1993;13:9-27.
14. Anderegg CR, Martin SJ, Gray JL, Mellonig JT, Gher ME. Clinical evaluation of the use of decalcified freeze-dried bone allograft with guided tissue regeneration in the treatment of molar furcation invasions. J Periodontol 1991;62:264-268.
15. Caffesse RG, Mota LF, Quiñones CR, Morrison EC. Clinical comparison of absorbable and non-absorbable barriers for guided periodontal tissue regeneration. J Clin Periodontol 1997;24:747-752.
16. Black BS, Gher ME, Sandifer JB, Fucini SE, Richardson AC. Comparative study of collagen and expanded polytetrafluoroethylene membranes in the treatment of human Class II furcation defects. J Periodontol 1994;65:598-604.
17. Caton J, Greenstein G, Sappa U. Synthetic bioabsorbable barrier for regeneration in human periodontal defects. J Periodontol 1994;65:1037-1045.
18. Christgau M, Schmalz G, Reich E, Wenzel A. Clinical and radiographical split-mouth-study on absorbable versus non-resorbable GTR-membranes. J Clin Periodontol 1995;22:306-315.
19. Eickholz P, Kim TS, Holle R. Guided tissue regeneration with non-resorbable and biodegradable barriers: 6 months results. J Clin Periodontol 1997;24:92-101.
20. Garrett S, Polson AM, Stoller NH, et al. Comparison of a bioabsorbable GTR barrier to a non-absorbable barrier in treating human Class II furcation defects. A multi-center parallel design randomized single-blind trial. J Periodontol 1997;68:667-675.
21. Yukna RA, Evans GH, Aichelmann-Reidy MB, Hayer ET. Clinical comparison of bioactive glass bone replacement graft material in expanded polytetrafluoroethylene barrier membrane in treating human mandibular molar Class II furcations. J Periodontol 2001;72:125-133.
22. Paolantonio M. Combined periodontal regenerative technique in human intrabony defects by collagen membranes and anorganic bovine bone. A controlled clinical study. J Periodontol 2002;73:158-166.
23. Leonardis D, Garg AK, Pedrazzoli V, Pecora GE. Clinical evaluation of the treatment of Class II furcation involvements with bioabsorbable barriers along or associated with demineralized freeze-dried bone allografts. J Periodontol 1999;70:8-12.
24. Lynch SE. Methods for the evaluation of regenerative procedures. J Periodontol 1992;63:1085-1092.
25. Stahl S, Froum S, Kushner J. Healing responses of human intraosseous lesions following the use of debridement, grafting and citric acid root treatment. II. Clinical and histologic observations: One year post surgery. J Periodontol 1983;54:325-338.
26. Drago MR, Sullivan HC. A clinical and histological evaluation of autogenous iliac bone grafts in humans. Part II. External root resorption. J Periodontol 1973;44:614-625.
27. Hiatt WR, Schallhorn R, Aaronian A. The induction of new bone and cementum formation: IV. Microscopic examination of the periodontium following human bone and marrow allograft, autograft and non-graft periodontal regenerative procedures. J Periodontol 1978;49:495-512.
28. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.
29. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part II. J Periodontol 1989;60:675-682.
30. Bowers G, Felton F, Middleton C, et al. Histologic comparison of regeneration in human intrabony defects when osteogenin is combined with demineralized freeze-dried bone allograft and with purified bovine collagen. J Periodontol 1991;62:690-702.
31. Gottlow J, Nyman S, Lindhe J, Karring T, Wennström J. New attachment formation in the human periodontium by guided tissue regeneration. Case reports. J Clin Periodontol 1986;13:604-616.
32. Stahl S, Froum S, Tarnow D. Human histologic response to guided tissue regeneration techniques in intrabony lesions. J Clin Periodontol 1990;17:191-198.
33. Cole RT, Crigger M, Bogle G, Egelberg J, Selvig KA. Connective tissue regeneration to periodontally diseased teeth. J Periodontal Res 1980;15:1-9.
34. Camelo M, Nevins ML, Schenk RK, Rasperini G, Lynch SE, Nevins M. Clinical, radiographic and histologic evaluation of human periodontal defects treated with Bio-Oss and Bio-Gide. Int J Periodontics Restorative Dent 1998;18:321-331.
35. Mellonig JT. Human histologic evaluation of a bovine-derived bone xenograft in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent 2000;20:19-29.
36. Sculean A, Reich E, Chiantella G, Brecx M. Clinical and histological evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain). Int J Periodontics Restorative Dent 1999;19:157-163.
37. Mellonig JT. Enamel matrix derivative for periodontal reconstructive surgery: Technique and clinical and histologic case report. Int J Periodontics Restorative Dent 1999;19:9-19.
38. Yukna RA, Mellonig JT. Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series. J Periodontol 2000;71:752-759.
39. Boultreau PJ, Warren SM, Spector JA, Steinbrech DS, Mehrara DJ, Longaker MT. Factors in the fracture microenvironment induce primary osteoblast angiogenic cytokine production. Plast Reconstr Surg 2002;110:139-148.
40. Nash TJ, Howlett CR, Martin C, Steele I, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15:203-208.
41. Mitlak BH, Finkelman RD, Hill EL, et al. The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 1996;11:238-247.
42. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol 1992;63:515-525.
43. Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontol 1993;64:142-148.
44. Lynch SE, de Castilla GR, Williams RC, et al. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991;62:458-467.
45. Rutherford RB, Niekrash CE, Kennedy JE, Charette MF. Platelet-derived and insulin-derived growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodontal Res 1992;27:285-290.
46. Dennison D, Vallone D, Pinero G, Rittman B, Caffesse RG. Differential effect of TGF-beta1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts. J Periodontol 1994;65:641-648.
47. McAllister BS, Leeb-Lundberg F, Mellonig JT, Olson MS. The functional interaction of EFG and PDGF with bradykinin in the proliferation of human gingival fibroblasts. J Periodontol 1995;66:429-437.
48. Piche JE, Graves DT. Study of growth factor requirements of human bonederived cells. A comparison with human fibroblasts. Bone 1989;10:131-138.
49. Lacker KP, Oates TW, Hoang AM, Takacs V, Cochran DL. Development of an in vitro wound healing model for periodontal cells. J Periodontol 2000;71:226-237.
50. Giannobile WV, Hernandez RA, Finkelman RD, et al. Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. J Periodontal Res 1996;31:301-312.
51. Park JB, Matsuura M, Han KY, et al. Periodontal regeneration in Class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor. J Periodontol 1995;66:462-477.
52. Cho MI, Lin WL, Genco RJ. Platelet-derived growth factor modulated guided tissue regeneration therapy. J Periodontol 1995;66:522-530.
53. Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile VVV, Lynch SE. A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-I like growth factor-I in patients with periodontal disease. J Periodontol 1997;68:1186-1193.
54. Lynch SE, Genco RJ, Marx R. Tissue Engineering Applications in Maxillofacial Surgery and Periodontics. Chicago: Quintessence, 1999.