Tumor spheroids as an in vitro model for determining the therapeutic response to proton beam radiotherapy and thermally sensitive nanocarriers

Theranostics

Volumn 3, Issue 9, 2013, Pages 687-691

  Senavirathna, Lakmini K ^a   Fernando, Ruchika ^a   Maples, Danny ^a   Zheng, Yuanshui ^b   Polf, Jerimy C ^a   Ranjan, Ashish ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b ProCure Proton Therapy Center   (United States)

Author keywords

Drug delivery; Liposomes; Proton beam radiotherapy; Tumor spheroids

Indexed keywords

DOXORUBICIN; LIPOSOME; NANOCARRIER;

ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG RELEASE; DRUG RESPONSE; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; IN VITRO STUDY; LOW TEMPERATURE; PARTICLE SIZE; PHOTON THERAPY; TEMPERATURE SENSE; TUMOR SPHEROID;

DRUG DELIVERY; LIPOSOMES; PROTON BEAM RADIOTHERAPY; TUMOR SPHEROIDS;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG THERAPY; LIPOSOMES; MODELS, BIOLOGICAL; NEOPLASMS; PROTON THERAPY;

EID: 84883152346     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.6381     Document Type: Article

References (13)

1. Ho WY, Yeap SK, Ho CL, Rahim RA, Alitheen NB. Development of multicellular tumor spheroid (MCTS) culture from breast cancer cell and a high throughput screening method using the MTT assay. PloS one. 2012; 7: e44640.
2. Perche F, Patel NR, Torchilin VP. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model. Journal of controlled release : official journal of the Controlled Release Society. 2012; 164: 95-102.
3. Huo S, Ma H, Huang K, Liu J, Wei T, Jin S, et al. Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors. Cancer research. 2013; 73: 319-30.
4. Cho K, Shin HW, Kim YI, Cho CH, Chun YS, Kim TY, et al. Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function. Free radical biology & medicine. 2013; 60: 201-10.
5. Grainger SJ, Serna JV, Sunny S, Zhou Y, Deng CX, El-Sayed ME. Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids. Molecular pharmaceutics. 2010; 7: 2006-19.
6. Jin S, Ma X, Ma H, Zheng K, Liu J, Hou S, et al. Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids. Nanoscale. 2013; 5: 143-6.
7. Ranjan A, Jacobs GC, Woods DL, Negussie AH, Partanen A, Yarmolenko PS, et al. Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. Journal of controlled release. 2012; 158: 487-94.
8. Polf JC, Bronk LF, Driessen WH, Arap W, Pasqualini R, Gillin M. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles. Applied physics letters. 2011; 98: 193702.
9. Kim JK, Seo SJ, Kim KH, Kim TJ, Chung MH, Kim KR, et al. Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect. Nanotechnology. 2010; 21: 425102.
10. Negussie AH, Yarmolenko PS, Partanen A, Ranjan A, Jacobs G, Woods D, et al. Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. Int J Hyperther. 2011; 27: 140-55.
11. Mayer LD, Bally MB, Cullis PR. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochimica et biophysica acta. 1986; 857: 123-6.
12. Friedrich J, Eder W, Castaneda J, Doss M, Huber E, Ebner R, et al. A reliable tool to determine cell viability in complex 3-d culture: the acid phosphatase assay. Journal of biomolecular screening. 2007; 12: 925-37.
13. Seiwert TY, Salama JK, Vokes EE. The concurrent chemoradiation paradigm-general principles. Nature clinical practice Oncology. 2007; 4: 86-100