N-3 polyunsaturated fatty acids, body fat and inflammation

Obesity Facts

Volumn 6, Issue 4, 2013, Pages 369-379

  Lund, Anne Sofie Q ^a   Hasselbalch, Ann Louise ^a   Gamborg, Michael ^a   Skogstrand, Kristin ^a   Hougaard, David M ^a   Heitmann, Berit L ^b   Kyvik, Kirsten O ^c   Sørensen, Thorkild I A ^a   Jess, Tine ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b Institute of Preventive Medicine   (Canada)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Anthropometry; Fat mass; Inflammation; Polyunsaturated fatty acids

Indexed keywords

ALCOHOL; C REACTIVE PROTEIN; INTERLEUKIN 18; INTERLEUKIN 6; LINOLENIC ACID; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OMEGA 3 FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADULT; AGED; ALCOHOL CONSUMPTION; ANTHROPOMETRY; ARTICLE; BICYCLE ERGOMETRY; BODY FAT; BODY FAT DISTRIBUTION; BREAST FEEDING; CALORIC INTAKE; CARDIOVASCULAR DISEASE; CLINICAL EXAMINATION; DIABETES MELLITUS; DIETARY INTAKE; DIZYGOTIC TWINS; DRUG ABUSE; FAT FREE MASS; FAT MASS; FEMALE; FITNESS; FOOD FREQUENCY QUESTIONNAIRE; FOOD INTAKE; HUMAN; INFLAMMATION; MACRONUTRIENT; MALE; METABOLIC SYNDROME X; NORMAL HUMAN; OBESITY; OXYGEN CONSUMPTION; PRACTICE GUIDELINE; PREGNANCY; PRIORITY JOURNAL; SKINFOLD THICKNESS; SMOKING; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; FOLLOW UP; HIP CIRCUMFERENCE; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; WAIST CIRCUMFERENCE;

EID: 84883151947     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000354663     Document Type: Article

References (45)

1. Trayhurn P: Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 2005; 184: 285-293.
2. Hotamisligil GS: Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
3. Horng T, Hotamisligil GS. Linking the inflammasome to obesity-related disease. Nat Med 2011; 17: 164-165.
4. Rajala MW, Scherer PE: Minireview: the adipocyte -at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144: 3765-3773.
5. Trayhurn P, Wood IS: Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92: 347-355.
6. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280:E745-E751.
7. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-2415.
8. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB: The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995; 95: 2111-2119.
9. Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J, Bastard JP. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord 2004; 28: 993-997.
10. Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW: Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004; 145: 2273-2282.
11. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, DAndrea F, Molinari AM, Giugliano D: Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002; 105: 804-809.
12. Panagiotakos DB, Pitsavos C, Yannakoulia M, Chrysohoou C, Stefanadis C: The implication of obesity and central fat on markers of chronic inflammation: the ATTICA study. Atherosclerosis 2005; 183: 308-315.
13. Ryan AS, Nicklas BJ: Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women. Diabetes Care 2004; 27: 1699-1705.
14. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B: Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000; 85: 3338-3342.
15. Fedor D, Kelley DS: Prevention of insulin resistance by n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care 2009; 12: 138-146.
16. Robinson LE, Buchholz AC, Mazurak VC: Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome. Appl Physiol Nutr Metab 2007; 32: 1008-1024.
17. Burdge GC, Calder PC: Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 2005; 45: 581-597.
18. Buckley JD, Howe PR: Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids. Obes Rev 2009; 10: 648-659.
19. Couet C, Delarue J, Ritz P, Antoine JM, Lamisse F: Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord 1997; 21: 637-643.
20. Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulange A, Vidal H, Slama G, Clement K, Guerre-Millo M, Rizkalla SW: Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr 2007; 86: 1670-1679.
21. Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, Ruzickova J, Sponarova J, Drahota Z, Vlcek C, Keijer J, Houstek J, Kopecky J: Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 2005; 48: 2365-2375.
22. Perez-Matute P, Perez-Echarri N, Martinez JA, Marti A, Moreno-Aliaga MJ: Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. Br J Nutr 2007; 97: 389-398.
23. Peyron-Caso E, Quignard-Boulange A, Laromiguiere M, Feing-Kwong-Chan S, Veronese A, Ardouin B, Slama G, Rizkalla SW: Dietary fish oil increases lipid mobilization but does not decrease lipid storage-related enzyme activities in adipose tissue of insulin-resistant, sucrose-fed rats. J Nutr 2003; 133: 2239-2243.
24. Ruzickova J, Rossmeisl M, Prazak T, Flachs P, Sporanova J, Veck M, Tvrzicka E, Bryhn M, Kopecky J: Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 2004; 39: 1177-1185.
25. Calder PC: Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res 2008; 52: 885-897.
26. Madsen L, Pedersen LM, Liaset B, Ma T, Petersen RK, van den Berg S, Pan J, Mller-Decker K, Dlsner ED, Kleemann R, Kooistra T, Dskeland SO, Kristiansen K: cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. J Biol Chem 2008; 283: 7196-7205.
27. Schousboe K, Visscher PM, Henriksen JE, Hopper JL, Srensen TIA, Kyvik KO: Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. Diabetologia 2003; 46: 1276-1283.
28. Schousboe K, Visscher PM, Erbas B, Kyvik KO, Hopper JL, Henriksen JE, Heitmann BL, Srensen TIA: Twin study of genetic and environmental influences on adult body size, shape, and composition. Int J Obes Relat Metab Disord 2004; 28: 39-48.
29. Overvad K, Tjonneland A, Haraldsdottir J, Ewertz M, Jensen OM: Development of a semiquantitative food frequency questionnaire to assess food, energy and nutrient intake in Denmark. Int J Epidemiol 1991; 20: 900-905.
30. Tjonneland A, Overvad K, Haraldsdottir J, Bang S, Ewertz M, Jensen OM: Validation of a semiquantitative food frequency questionnaire developed in Denmark. Int J Epidemiol 1991; 20: 906-912.
31. Lauritsen J: FoodCalc version 1.3. www.ibt dk/jesper/foodcalc . 2007 (last accessed July 30, 2013).
32. Mller A, Saxholt E. Levnedmiddeltabeller (Food composition tables). 4 edn. Copenhagen, Levnedsmiddelstyrelsen (National Food Agency), 1996.
33. Hasselbalch AL, Heitmann BL, Kyvik KO, Srensen TIA: Studies of twins indicate that genetics influence dietary intake. J Nutr 2008; 138: 2406-2412.
34. Heitmann BL: Evaluation of body fat estimated from body mass index, skinfolds and impedance. A comparative study. Eur J Clin Nutr 1990; 44: 831-837.
35. Skogstrand K, Ekelund CK, Thorsen P, Vogel I, Jacobsson B, Nrgaard-Pedersen B, Hougaard DM: Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples. J Immunol Methods 2008; 336: 78-84.
36. Skogstrand K, Thorsen P, Norgaard-Pedersen B, Schendel DE, Sorensen LC, Hougaard DM: Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology. Clin Chem 2005; 51: 1854-1866.
37. Summerbell CD, Douthwaite W, Whittaker V, Ells LJ, Hiller F, Smith S, Kelly S, Edmunds LD, Macdonald I: The association between diet and physical activity and subsequent excess weight gain and obesity assessed at 5 years of age or older: a systematic review of the epidemiological evidence. Int J Obes (Lond) 2009; 33(suppl 3):S1-92.
38. Huang XF, Xin X, McLennan P, Storlien L: Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression. Diabetes Obes Metab 2004; 6: 35-44.
39. Raclot T, Groscolas R, Langin D, Ferre P: Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 1997; 38: 1963-1972.
40. Micallef MA, Munro IA, Garg ML: An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Eur J Clin Nutr 2009; 63: 1154-1156.
41. Kratz M, Callahan HS, Yang PY, Matthys CC, Weigle DS: Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial. Nutr Metab (Lond) 2009; 6: 24.
42. Kratz M, Swarbrick MM, Callahan HS, Matthys CC, Havel PJ, Weigle DS: Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women. Am J Clin Nutr 2008; 87: 347-353.
43. Simopoulos AP: Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 2006; 60: 502-507.
44. Skurk T, Berti-Huber C, Herder C, Hauner H: Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 2007; 92: 1023-1033.
45. Glintborg D, Andersen M, Richelsen B, Bruun JM: Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment. Clin Endocrinol (Oxf) 2009; 71: 652-658.