Antibodies against food antigens in patients with autistic spectrum disorders

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  De Magistris, Laura ^a   Picardi, Annarita ^a   Siniscalco, Dario ^a   Riccio, Maria Pia ^a   Sapone, Anna ^a   Cariello, Rita ^a   Abbadessa, Salvatore ^a   Medici, Nicola ^a   Lammers, Karen M ^b   Schiraldi, Chiara ^a   Iardino, Patrizia ^a   Marotta, Rosa ^c   Tolone, Carlo ^a   Fasano, Alessio ^b   Pascotto, Antonio ^a   Bravaccio, Carmela ^d  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LACTALBUMIN; ANTIBODY; BETA LACTOGLOBULIN; CASEIN; ENDOMYSIUM ANTIBODY; FOOD ANTIGEN ANTIBODY; GLIADIN ANTIBODY; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; UNCLASSIFIED DRUG; ANTIGEN; GLIADIN; IMMUNOGLOBULIN A;

ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; AUTISM; CELIAC DISEASE; CHILD; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HAPLOTYPE; HLA TYPING; HUMAN; IMMUNE RESPONSE; INTESTINE MUCOSA PERMEABILITY; MAJOR CLINICAL STUDY; MALE; SCHOOL CHILD; FOOD; IMMUNOLOGY; INTESTINE; PATHOLOGY; PERMEABILITY;

ANTIBODIES; ANTIGENS; CELIAC DISEASE; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; FEMALE; FOOD; GLIADIN; HAPLOTYPES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTESTINES; MALE; PERMEABILITY;

EID: 84883139166     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/729349     Document Type: Article

References (42)

1. Johnson C. P., Myers S. M., Lipkin P. H., Cartwright J. D., Desch L. W., Duby J. C., Elias E. R., Levey E. B., Liptak G. S., Murphy N. A., Tilton A. H., Lollar D., Macias M., McPherson M., Olson D. G., Strickland B., Skipper S. M., Ackermann J., Del Monte M., Challman T. D., Hyman S. L., Levy S. E., Spooner S. A., Yeargin-Allsopp M., Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007 120 5 1183 1215 2-s2.0-36048931014 10.1542/peds.2007-2361
2. Campbell D. B., Sutcliffe J. S., Ebert P. J., Militerni R., Bravaccio C., Trillo S., Elia M., Schneider C., Melmed R., Sacco R., Persico A. M., Levitt P., A genetic variant that disrupts MET transcription is associated with autism. Proceedings of the National Academy of Sciences of the United States of America 2006 103 45 16834 16839 2-s2.0-33750962208 10.1073/pnas.0605296103
3. Sacco R., Curatolo P., Manzi B., Militerni R., Bravaccio C., Frolli A., Lenti C., Saccani M., Elia M., Reichelt K.-L., Pascucci T., Puglisi-Allegra S., Persico A. M., Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Research 2010 3 5 237 252 2-s2.0-79251485318 10.1002/aur.151
4. Sacco R., Lenti C., Saccani M., Curatolo P., Manzi B., Bravaccio C., Persico A. M., Cluster analysis of autistic patients based on principal pathogenetic components. Autism Research 2012 5 2 137 147 10.1002/aur.1226
5. Theoharides T. C., Doyle R., Francis K., Conti P., Kalogeromitros D., Novel therapeutic targets for autism. Trends in Pharmacological Sciences 2008 29 8 375 382 2-s2.0-48049111366 10.1016/j.tips.2008.06.002
6. de Theije C. G. M., Wu J., da Silva S. L., Kamphuis P. J., Garssen J., Korte S. M., Kraneveld A. D., Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management. European Journal of Pharmacology 2011 668 supplement 1 S70 S80 2-s2.0-81155159738 10.1016/j.ejphar.2011.07.013
7. Buie T., Campbell D. B., Fuchs G. J. III, Furuta G. T., Levy J., van de Water J., Whitaker A. H., Atkins D., Bauman M. L., Beaudet A. L., Carr E. G., Gershon M. D., Hyman S. L., Jirapinyo P., Jyonouchi H., Kooros K., Kushak R., Levitt P., Levy S. E., Lewis J. D., Murray K. F., Natowicz M. R., Sabra A., Wershil B. K., Weston S. C., Zeltzer L., Winter H., Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010 125 supplement 1 S1 S18 2-s2.0-73949128465 10.1542/peds.2009-1878C
8. de Magistris L., Familiari V., Pascotto A., Sapone A., Frolli A., Iardino P., Carteni M., de Rosa M., Francavilla R., Riegler G., Militerni R., Bravaccio C., Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. Journal of Pediatric Gastroenterology and Nutrition 2010 51 4 418 424 2-s2.0-78449231774 10.1097/MPG.0b013e3181dcc4a5
9. Millward C., Ferriter M., Calver S., Connell-Jones G., Gluten- and casein-free diets for autistic spectrum disorder. Cochrane Database of Systematic Reviews 2004 2 CD003498 2-s2.0-3843112401
10. Hsu C. L., Lin C. Y., Chen C. L., Wang C. M., Wong M. K., The effects of a gluten and casein-free diet in children with autism: a case report. Chang Gung Medical Journal 2009 32 4 459 465 2-s2.0-70349180841
11. Whiteley P., Haracopos D., Knivsberg A.-M., Reichelt K. L., Parlar S., Jacobsen J., Seim A., Pedersen L., Schondel M., Shattock P., The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutritional Neuroscience 2010 13 2 87 100 2-s2.0-77951116456 10.1179/ 147683010X12611460763922
12. Pennesi C. M., Klein L. C., Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: based on parental report. Nutritional Neuroscience 2012 15 2 85 91 2-s2.0-84858767189 10.1179/1476830512Y.0000000003
13. Gupta S., Samra D., Agrawal S., Adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin. Journal of Clinical Immunology 2010 30 1 S90 S96 2-s2.0-77956184652 10.1007/s10875-010- 9402-9
14. Onore C., Careaga M., Ashwood P., The role of immune dysfunction in the pathophysiology of autism. Brain, Behavior, and Immunity 2012 26 3 383 392 2-s2.0-84857190395 10.1016/j.bbi.2011.08.007
15. Wasilewska J., Kaczmarski M., Stasiak-Barmuta A., Tobolczyk J., Kowalewska E., Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old. Archives of Medical Science 2012 8 324 331
16. Castellani M. L., Conti C. M., Kempuraj D. J., Salini V., Vecchiet J., Tetè S., Ciampoli C., Conti F., Cerulli G., Caraffa A., Antinolfi P., Galzio R., Shaik Y., Theoharides T. C., de Amicis D., Perrella A., Cuccurullo C., Boscolo P., Felaco M., Doyle R., Verrocchio C., Fulcheri M., Autism and immunity: revisited study. International Journal of Immunopathology and Pharmacology 2009 22 1 15 19 2-s2.0-62649087603
17. Bakkaloglu B., Anlar B., Anlar F. Y., Öktem F., Pehlivantürk B., Ünal F., Ozbesler C., Gökler B., Atopic features in early childhood autism. European Journal of Paediatric Neurology 2008 12 6 476 479 2-s2.0-48049114665 10.1016/j.ejpn.2007.12.008
18. Jyonouchi H., Geng L., Ruby A., Reddy C., Zimmerman-Bier B., Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. Journal of Pediatrics 2005 146 5 605 610 2-s2.0-18144423139 10.1016/j.jpeds. 2005.01.027
19. + lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. Journal of Neuroimmunology 2006 173 1 126 134 2-s2.0-33644951883 10.1016/j.jneuroim.2005.12.007
20. Jyonouchi H., Sun S., Itokazu N., Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 2002 46 2 76 84 2-s2.0-0036970874 10.1159/000065416
21. Vojdani A., O'Bryan T., Green J. A., McCandless J., Woeller K. N., Vojdani E., Nourian A. A., Cooper E. L., Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutritional Neuroscience 2004 7 3 151 161 2-s2.0-4744374906 10.1080/10284150400004155
22. Lucarelli S., Frediani T., Zingoni A. M., Ferruzzi F., Giardini O., Quintieri F., Barbato M., D'Eufemia P., Cardi E., Food allergy and infantile autism. Panminerva Medica 1995 37 3 137 141 2-s2.0-0029362122
23. Genuis S. J., Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity. Science of the Total Environment 2010 408 24 6047 6061 2-s2.0-77958107727 10.1016/j.scitotenv.2010. 08.047
24. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders 2000 4th Washington, DC, USA American Psychiatric Association
25. Lord C., Rutter M., Le Couteur A., Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 1994 24 5 659 685 2-s2.0-0027997172 10.1007/BF02172145
26. Schopler E., Reichler R. J., Renner B. R., The Childhood Autism Rating Scale (CARS) 1988 Los Angeles, Calif, USA Western Psychological Service
27. Lord C., Risi S., Lambrecht L., Cook E. H. Jr., Leventhal B. L., Dilavore P. C., Pickles A., Rutter M., The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders 2000 30 3 205 223 2-s2.0-0033802632 10.1023/A:1005592401947
28. Generoso M., de Rosa M., de Rosa R., de Magistris L., Secondulfo M., Fiandra R., Carratù R., Cartenì M., Cellobiose and lactulose coupled with mannitol and determined using ion-exchange chromatography with pulsed amperometric detection, are reliable probes for investigation of intestinal permeability. Journal of Chromatography B 2003 783 2 349 357 2-s2.0-0037437589 10.1016/S1570-0232(02)00766-3
29. D'Eufemia P., Celli M., Finocchiaro R., Pacifico L., Viozzi L., Zaccagnini M., Cardi E., Giardini O., Abnormal intestinal permeability in children with autism. Acta Paediatrica 1996 85 9 1076 1079 2-s2.0-0029780418
30. Amarri S., Alvisi P., DeGiorgio R., Gelli M. C., Cicola R., Tovoli F., Sassatelli R., Caio G., Volta U., Antibodies to deamidated gliadin peptides: an accurate predictor of celiac disease in infancy. Journal of Clinical Immunology 2013 33 5 1027 1030 10.1007/s10875-013-9888-z
31. Cerutti A., The regulation of IgA class switching. Nature Reviews Immunology 2008 8 6 421 434 2-s2.0-44349195660 10.1038/nri2322
32. Critchfield J. W., van Hemert S., Ash M., Mulder L., Ashwood P., The potential role of probiotics in the management of childhood autism spectrum disorders. Gastroenterology Research and Practice 2011 2011 8 2-s2.0-84855269225 10.1155/2011/161358 161358
33. Williams B. L., Hornig M., Buie T., Bauman M. L., Cho Paik M., Wick I., Bennett A., Jabado O., Hirschberg D. L., Lipkin W. I., Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS ONE 2011 6 9 2-s2.0-80052848478 10.1371/journal.pone.0024585 e24585
34. Siniscalco D., Sapone A., Giordano C., Cirillo A., de Novellis V., de Magistris L., Rossi F., Fasano A., Maione S., Antonucci N., The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients. Journal of Autism and Developmental Disorders 2012 42 7 1403 1410 2-s2.0-80053356667 10.1007/s10803-011-1373-z
35. Fasano A., Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological Reviews 2011 91 1 151 175 2-s2.0-78751699186 10.1152/physrev.00003.2008
36. Angelidou A., Francis K., Vasiadi M., Alysandratos K.-D., Zhang B., Theoharides A., Lykouras L., Sideri K., Kalogeromitros D., Theoharides T. C., Neurotensin is increased in serum of young children with autistic disorder. Journal of Neuroinflammation 2010 7, article 48 2-s2.0-77955834453 10.1186/1742-2094-7-48
37. Angelidou A., Asadi S., Alysandratos K. D., Karagkouni A., Kourembanas S., Theoharides T. C., Perinatal stress, brain inflammation and the risk of autism. BCM Pediatrics 2012 12, article 89 10.1186/1471-2431-12-89
38. Pavone L., Fiumara A., Bottaro G., Mazzone D., Coleman M., Autism and celiac disease: failure to validate the hypothesis that a link might exist. Biological Psychiatry 1997 42 1 72 75 2-s2.0-0030837337 10.1016/S0006-3223(97) 00267-9
39. Batista I. C., Gandolfi L., Nobrega Y. K. M., Almeida R. C., Almeida L. M., Campos D. Jr., Pratesi R., Autism spectrum disorder and celiac disease: no evidence for a link. Arquivos de Neuro-Psiquiatria 2012 70 1 28 33 2-s2.0-84855483983 10.1590/S0004-282X2012000100007
40. Biesiekierski J. R., Newnham E. D., Irving P. M., Barrett J. S., Haines M., Doecke J. D., Shepherd S. J., Muir J. G., Gibson P. R., Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. American Journal of Gastroenterology 2011 106 3 508 514 2-s2.0-79952362194 10.1038/ajg.2010.487
41. Sapone A., Lammers K. M., Casolaro V., Cammarota M., Giuliano M. T., de Rosa M., Stefanile R., Mazzarella G., Tolone C., Russo M. I., Esposito P., Ferraraccio F., Cartenì M., Riegler G., de Magistris L., Fasano A., Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Medicine 2011 9, article 23 2-s2.0-79952326609 10.1186/1741-7015-9-23
42. Sapone A., Bai J. C., Ciacci C., Dolinsek J., Green P. H. R., Hadjivassiliou M., Kaukinen K., Rostami K., Sanders D. S., Schumann M., Ullrich R., Villalta D., Volta U., Catassi C., Fasano A., Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Medicine 2012 10, article 13 2-s2.0-84856578917 10.1186/1741-7015-10-13