Cluster analysis of autistic patients based on principal pathogenetic components

Autism Research

Volumn 5, Issue 2, 2012, Pages 137-147

  Sacco, Roberto ^a,b   Lenti, Carlo ^c   Saccani, Monica ^c   Curatolo, Paolo ^d   Manzi, Barbara ^d   Bravaccio, Carmela ^e   Persico, Antonio M ^a,b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cluster analysis; Immune system; Neurodevelopment; Pervasive developmental disorders; Principal component analysis

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTISM; BEHAVIOR DISORDER; CHILD; CIRCADIAN RHYTHM SLEEP DISORDER; DEVELOPMENTAL DISORDER; FEMALE; HUMAN; IDIOPATHIC DISEASE; IMMUNOPATHOLOGY; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; PHENOTYPE; PRESCHOOL CHILD; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SCHOOL CHILD; SENSORY DYSFUNCTION; CLASSIFICATION; CLUSTER ANALYSIS; ITALY; PATHOPHYSIOLOGY; SLEEP DISORDER; STEREOTYPY;

ADOLESCENT; ADULT; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; CHRONOBIOLOGY DISORDERS; CLUSTER ANALYSIS; DEVELOPMENTAL DISABILITIES; FEMALE; HUMANS; IMMUNE SYSTEM DISEASES; ITALY; MALE; PRINCIPAL COMPONENT ANALYSIS; SENSATION DISORDERS; STEREOTYPED BEHAVIOR;

EID: 84865329000     PISSN: 19393792     EISSN: 19393806     Source Type: Journal    
DOI: 10.1002/aur.1226     Document Type: Article

References (52)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Press.
2. Arango, C. (2010). Clinical subtyping and early detection: Short-term challenges for child and adolescent psychiatry. European Child and Adolescent Psychiatry, 19, 627- 628.
3. Balottin, U., Bejor, M., Cecchini, A., Martelli, A., Palazzi, S., & Lanzi, G. (1989). Infantile autism and computerized tomography brain-scan findings: Specific versus nonspecific abnormalities. Journal of Autism and Developmental Disorders, 19, 109-117.
4. Bauman, M.L., & Kemper, T.L. (2005). Neuroanatomic observations of the brain in autism: A review and future directions. International Journal of Developmental Neuroscience, 23, 183-187.
5. Ben-Sasson, A., Cermak, S.A., Orsmond, G.I., Tager-Flusberg, H., Kadlec, M.B., & Carter, A.S. (2008). Sensory clusters of toddlers with autism spectrum disorders: Differences in affective symptoms. Journal of Child Psychology and Psychiatry, 49, 817-825.
6. Bitsika, V., Sharpley, C.F., & Orapeleng, S. (2008). An exploratory analysis of the use of cognitive, adaptive and behavioural indices for cluster analysis of ASD subgroups. Journal of Intellectual Disability Research, 52, 973-985.
7. Bruining, H., de Sonneville, L., Swaab, H., de Jonge, M., Kas, M., et al. (2010). Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes. PLoS ONE, 5, e10887, 1-7.
8. Buxbaum, J.D. (2009). Multiple rare variants in the etiology of autism spectrum disorders. Dialogues in Clinical Neuroscience, 11, 35-43.
9. Constantino, J.N., Gruber, C.P., Davis, S., Hayes, S., Passanante, N., & Przybeck, T. (2004). The factor structure of autistic traits. Journal of Child Psychology and Psychiatry, 45, 719- 726.
10. Doetschman, T. (2009). Influence of genetic background on genetically engineered mouse phenotypes. Methods in Molecular Biology, 530, 423-433.
11. Duda, R.O., Hart, P.E., & Stork, D.G. (2001). Pattern classification, 2nd ed. New York: John Wiley & Sons.
12. Eaves, L.C., Ho, H.H., & Eaves, D.M. (1994). Subtypes of autism by cluster analysis. Journal of Autism and Developmental Disorders, 24, 3-22.
13. Fein, D., Stevens, M., Dunn, M., Waterhouse, L., Allen, D., et al. (1999). Subtypes of pervasive developmental disorder: Clinical characteristics. Child Neuropsychology, 5, 1-23.
14. Garon, N., Bryson, S.E., Zwaigenbaum, L., Smith, I.M., Brian, J., et al. (2009). Temperament and its relationship to autistic symptoms in a high-risk infant sib cohort. Journal of Abnormal Child Psychology, 37, 59-78.
15. Goines, P., & Van de Water, J. (2010). The immune system's role in the biology of autism. Current Opinion in Neurology, 23, 111-117.
16. Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The autism diagnostic observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37, 613-627.
17. Hair, J.F., Anderson, R.E., Tatham, R.L., & Black, W.C. (1995). Multivariate data analysis with readings, 4th ed. Upper Saddler River: Prentice-Hall.
18. Hameury, L., Roux, S., Barthélémy, C., Adrien, J.L., Desombre, H., et al. (1995). Quantified multidimensional assessment of autism and other pervasive developmental disorders. Application for bioclinical research. European Child and Adolescent Psychiatry, 4, 123-135.
19. Hrdlicka, M., Dudova, I., Beranova, I., Lisy, J., Belsan, T., et al. (2005). Subtypes of autism by cluster analysis based on structural MRI data. European Child and Adolescent Psychiatry, 14, 138-144.
20. Hu, V.W., & Steinberg, M.E. (2009). Novel clustering of items from the Autism Diagnostic Interview-Revised to define phenotypes within autism spectrum disorders. Autism Research, 2, 67-77.
21. Kim, S.H., & Lord, C. (2012). Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to months of age. Journal of Child Psychology and Psychiatry, 53, 143- 151.
22. Lane, A.E., Dennis, S.J., & Geraghty, M.E. (2011). Brief report: Further evidence of sensory subtypes in autism. Journal of Autism and Developmental Disorders, 41, 826-831.
23. van Lang, N.D., Boomsma, A., Sytema, S., de Bildt, A.A., Kraijer, D.W., et al. (2006). Structural equation analysis of a hypothesised symptom model in the autism spectrum. Journal of Child Psychology and Psychiatry, 47, 37-44.
24. Lintas, C., & Persico, A.M. (2009). Autistic phenotypes and genetic testing: State-of-the-art for the clinical geneticist. Journal of Medical Genetics, 46, 1-8.
25. Liss, M., Saulnier, C., Fein, D., & Kinsbourne, M. (2006). Sensory and attention abnormalities in autistic spectrum disorders. Autism, 10, 155-172.
26. Lord, C., Rutter, M., DiLavore, P.C., & Risi, S. (2002). Ados, autism diagnostic observation schedule. Los Angeles, CA: Western Psychological Services. Italian version by Tancredi, R., Saccani, M., Persico, A.M., Parrini, B., Igliozzi R., & Faggioli. R., editors (2005). Florence, Organizzazioni Speciali.
27. Luyster, R., Gotham, K., Guthrie, W., Coffing, M., Petrak, R., et al. (2009). The autism diagnostic observation scheduletoddler module: A new module of a standardized diagnostic measure for autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 1305-1320.
28. Malvy, J., Barthélémy, C., Damie, D., Lenoir, P., Bodier, C., & Roux, S. (2004). Behaviour profiles in a population of infants later diagnosed as having autistic disorder. European Child and Adolescent Psychiatry, 13, 115-122.
29. Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., et al. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13, 90-98.
30. Persico, A.M. (2012). Autisms. In P. Rakic & J. Rubenstein (Eds.), Comprehensive developmental neuroscience-basic and clinical mechanisms, a comprehensive reference San Diego, CA: Elsevier. in press.
31. Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154, 185-190.
32. Prior, M., Eisenmajer, R., Leekam, S., Wing, L., Gould, J., et al. (1998). Are there subgroups within the autistic spectrum? A cluster analysis of a group of children with autistic spectrum disorders. Journal of Child Psychology and Psychiatry, 39, 893-902.
33. Ring, H., Woodbury-Smith, M., Watson, P., Wheelwright, S., & Baron-Cohen, S. (2008). Clinical heterogeneity among people with high functioning autism spectrum conditions: Evidence favouring a continuous severity gradient. Behavioral and Brain Functions, 4:11, 1-6.
34. Roux, S., Malvy, J., Bruneau, N., Garreau, B., Guérin, P., et al. (1995). Identification of behaviour profiles with a population of autistic children using multivariate statistical methods. European Child and Adolescent Psychiatry, 4, 249-258.
35. Roux, S., Bruneau, N., Garreau, B., Guérin, P., Adrien, J.L., et al. (1997). Bioclinical profiles of autism and other developmental disorders using a multivariate statistical approach. Biological Psychiatry, 42, 1148-1156.
36. Rutter, M., Le Couter, A., & Lord, C. (2003). ADI-R, autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services. Italian version by Faggioli, R., Saccani, M., Persico, A.M., Tancredi, R., Parrini, B., & Igliozzi, R., editors (2005). Florence: Organizzazioni Speciali.
37. Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., et al. (2010). Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Research, 3, 237-252.
38. Saresella, M., Marventano, I., Guerini, F.R., Mancuso, R., Ceresa, L., et al. (2009). An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children. Biological Psychiatry, 66, 978-984.
39. Sevin, J.A., Matson, J.L., Coe, D., Love, S.R., Matese, M.J., & Benavidez, D.A. (1995). Empirically derived subtypes of pervasive developmental disorders: A cluster analytic study. Journal of Autism and Developmental Disorders, 25, 561- 578.
40. Sham, P.C., & Curtis, D. (1995). Monte Carlo tests for association between disease and alleles at highly polymorphic loci. Annals of Human Genetics, 59, 97-105.
41. Shao, Y., Cuccaro, M.L., Hauser, E.R., Raiford, K.L., Menold, M.M., et al. (2003). Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. American Journal of Human Genetics, 72, 539-548.
42. Siegel, B., Anders, T.F., Ciaranello, R.D., Bienenstock, B., & Kraemer, H.C. (1986). Empirically derived subclassification of the autistic syndrome. Journal of Autism and Developmental Disorders, 16, 275-293.
43. Snow, A.V., Lecavalier, L., & Houts, C. (2009). The structure of the Autism Diagnostic Interview-Revised: Diagnostic and phenotypic implications. Journal of Child Psychology and Psychiatry, 50, 734-742.
44. Sparrow, S.S., Balla, D.A., & Cicchetti, D.V. (1984). Vineland adaptive behavior scales-survey form. Circle Pines, MN: American Guidance Service.
45. Spiker, D., Lotspeich, L.J., Dimiceli, S., Myers, R.M., & Risch, N. (2002). Behavioral phenotypic variation in autism multiplex families: Evidence for a continuous severity gradient. American Journal of Medical Genetics, 11, 129-136.
46. Stevens, M.C., Fein, D.A., Dunn, M., Allen, D.,Waterhouse, L.H., et al. (2000). Subgroups of children with autism by cluster analysis: A longitudinal examination. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 346- 352.
47. Tabachnick, B.G., & Fidell, L.S. (1989). Using multivariate statistics, 2nd ed. New York: Harper & Row.
48. Tadevosyan-Leyfer, O., Dowd, M., Mankoski, R., Winklosky, B., Putnam, S., et al. (2003). A principal components analysis of the Autism Diagnostic Interview-Revised. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 864-872.
49. Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W., & Pardo, C.A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67-81.
50. Wiggins, L.D., Robins, D.L., Adamson, L.B., Bakeman, R., & Henrich, C.C. (2012). Support for a dimensional view of autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 42, 191-200.
51. Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. The Journal of Autism and Developmental Disorders, 9, 11-29.
52. Wolf, U. (1997). Identical mutations and phenotypic variation. Human Genetics, 100, 305-321.