Pin1-mediated Runx2 modification is critical for skeletal development

Journal of Cellular Physiology

Volumn 228, Issue 12, 2013, Pages 2377-2385

  Yoon, Won Joon ^a   Islam, Rabia ^a   Cho, Young Dan ^a   Woo, Kyung Mi ^a   Baek, Jeong Hwa ^a   Uchida, Takafumi ^b   Komori, Toshihisa ^c   van Wijnen, Andre ^d   Stein, Janet L ^e   Lian, Jane B ^e   Stein, Gary S ^e   Choi, Je Yong ^f   Bae, Suk Chul ^g   Ryoo, Hyun Mo ^a  

^a Seoul National University   (South Korea)

^b TOHOKU UNIVERSITY   (Japan)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF VERMONT   (United States)

^f Kyungpook National University School of Medicine   (South Korea)

^g Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDYLPROLYL ISOMERASE PIN1; TRANSCRIPTION FACTOR RUNX2; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; BONE DYSPLASIA; CLAVICLE; CLEIDOCRANIAL DYSPLASIA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FONTANEL; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CLEIDOCRANIAL DYSPLASIA; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HEK293 CELLS; HUMANS; MICE; MUTATION; OSTEOBLASTS; OSTEOGENESIS; PEPTIDYLPROLYL ISOMERASE; PHENOTYPE; PHOSPHORYLATION; PROTEOLYSIS; UBIQUITIN;

EID: 84883042547     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24403     Document Type: Article

References (27)

1. Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. 2003. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res 63:6244-6251.
2. Duffy JB, Gergen JP. 1991. The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene sex-lethal. Genes Dev 5:2176-2187.
3. Fujimori F, Takahashi K, Uchida C, Uchida T. 1999. Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun 265:658-663.
4. Ge C, Xiao G, Jiang D, Franceschi RT. 2007. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176:709-718.
5. Greives MR, Odessey EA, Waggoner DJ, Shenaq DS, Aradhya S, Mitchell A, Whitcomb E, Warshawsky N, He TC, Reid RR. 2013. RUNX2 quadruplication: Additional evidence toward a new form of syndromic craniosynostosis. J Craniofac Surg 24:126-129.
6. Hsu T, McRackan D, Vincent TS, Gert de Couet H. 2001. Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nat Cell Biol 3:538-543.
7. Kim HJ, Kim JH, Bae SC, Choi JY, Ryoo HM. 2003. The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278:319-326.
8. Kim HJ, Park HD, Kim JH, Cho JY, Choi JY, Kim JK, Shin HI, Ryoo HM. 2004. Establishment and characterization of a stable cell line to evaluate cellular Runx2 activity. J Cell Biochem 91:1239-1247.
9. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
10. Lee TH, Tun-Kyi A, Shi R, Lim J, Soohoo C, Finn G, Balastik M, Pastorino L, Wulf G, Zhou XZ, Lu KP. 2009. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol 11:97-105.
11. Lou Y, Javed A, Hussain S, Colby J, Frederick D, Pratap J, Xie R, Gaur T, van Wijnen AJ, Jones SN, Stein GS, Lian JB, Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18:556-568.
12. Lu KP, Finn G, Lee TH, Nicholson LK. 2007. Prolyl cis-trans isomerization as a molecular timer. Nat Chem Biol 3:619-629.
13. Lu KP, Zhou XZ. 2007. The prolyl isomerase PIN1: A pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol 8:904-916.
14. Lu PJ, Zhou XZ, Shen M, Lu KP. 1999. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283:1325-1328.
15. McLeod MJ. 1980. Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22:299-301.
16. Mefford HC, Shafer N, Antonacci F, Tsai JM, Park SS, Hing AV, Rieder MJ, Smyth MD, Speltz ML, Eichler EE, Cunningham ML. 2010. Copy number variation analysis in single-suture craniosynostosis: Multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis. Am J Med Genet A 152A:2203-2210.
17. Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JH, Owen MJ, Mertelsmann R, Zabel BU, Olsen BR. 1997. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89:773-779.
18. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y. 1999. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 93:1817-1824.
19. Park OJ, Kim HJ, Woo KM, Baek JH, Ryoo HM. 2010. FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization. J Biol Chem 285:3568-3574.
20. Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G. 2010. Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. Leukemia 24:914-923.
21. Ranganathan R, Lu KP, Hunter T, Noel JP. 1997. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89:875-886.
22. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG. 1999. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 23:166-175.
23. Tatara Y, Lin YC, Bamba Y, Mori T, Uchida T. 2009. Dipentamethylene thiuram monosulfide is a novel inhibitor of Pin1. Biochem Biophys Res Commun 384:394-398.
24. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. 1997. Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science 278:1957-1960.
25. Yeh ES, Means AR. 2007. PIN1, the cell cycle and cancer. Nat Rev Cancer 7:381-388.
26. Yoshida T, Kanegane H, Osato M, Yanagida M, Miyawaki T, Ito Y, Shigesada K. 2002. Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Am J Hum Genet 71:724-738.
27. Yoshida T, Kanegane H, Osato M, Yanagida M, Miyawaki T, Ito Y, Shigesada K. 2003. Functional analysis of RUNX2 mutations in cleidocranial dysplasia: Novel insights into genotype-phenotype correlations. Blood Cells Mol Dis 30:184-193.